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    Ccdc65 coiled-coil domain containing 65 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362994, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ccdc65provided by RGD
    Official Full Name
    coiled-coil domain containing 65provided by RGD
    Primary source
    RGD:1595842
    See related
    EnsemblRapid:ENSRNOG00000058916 AllianceGenome:RGD:1595842
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in axonemal dynein complex assembly; cilium-dependent cell motility; and regulation of cilium movement. Predicted to be located in ciliary basal body. Predicted to be part of axonemal dynein complex. Predicted to be active in axoneme. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 27. Orthologous to human CCDC65 (coiled-coil domain containing 65). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 135.5), Brain (RPKM 35.5) and 5 other tissues See more
    Orthologs
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    Genomic context

    See Ccdc65 in Genome Data Viewer
    Location:
    7q36
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (131736002..131749761)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (129857118..129870803)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (140383395..140397186)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene tubulin, alpha 1C Neighboring gene DEAD-box helicase 23 Neighboring gene uncharacterized LOC103692978 Neighboring gene Rho family GTPase 1 Neighboring gene FKBP prolyl isomerase 11 Neighboring gene ARF GTPase 3

    Genomic regions, transcripts, and products

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in axonemal dynein complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cilium assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cilium-dependent cell motility IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of cilium movement IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of cilium movement ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of axonemal dynein complex IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in axoneme IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in ciliary basal body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in motile cilium IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    dynein regulatory complex subunit 2
    Names
    coiled-coil domain-containing protein 65

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014203.1NP_001014225.1  dynein regulatory complex subunit 2

      See identical proteins and their annotated locations for NP_001014225.1

      Status: PROVISIONAL

      Source sequence(s)
      BC083683
      UniProtKB/Swiss-Prot
      Q5XIJ8
      UniProtKB/TrEMBL
      A6KC99
      Related
      ENSRNOP00000071850.2, ENSRNOT00000090760.3
      Conserved Domains (1) summary
      pfam14772
      Location:27124
      NYD-SP28; Sperm tail

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      131736002..131749761
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063263952.1XP_063120022.1  dynein regulatory complex subunit 2 isoform X1

      Related
      ENSRNOP00000108892.1, ENSRNOT00000137510.1
    2. XM_063263953.1XP_063120023.1  dynein regulatory complex subunit 2 isoform X2

    3. XM_063263954.1XP_063120024.1  dynein regulatory complex subunit 2 isoform X3

      UniProtKB/TrEMBL
      A6KCA1