Hint1 histidine triad nucleotide binding protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Hint1provided by RGD
Official Full Name: histidine triad nucleotide binding protein 1provided by RGD
Primary source: RGD:1593411
See related: EnsemblRapid:ENSRNOG00000086472 AllianceGenome:RGD:1593411
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Pkci; Prkci
Summary: Predicted to enable adenosine 5'-monophosphoramidase activity and deSUMOylase activity. Predicted to be involved in several processes, including intrinsic apoptotic signaling pathway by p53 class mediator; positive regulation of calcium-mediated signaling; and protein desumoylation. Predicted to be located in cytosol; nucleoplasm; and plasma membrane. Predicted to be part of histone deacetylase complex. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in Gamstorp-Wohlfart syndrome. Orthologous to human HINT1 (histidine triad nucleotide binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 1717.4), Muscle (RPKM 1417.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q22

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (39490225..39493970)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (38989516..38993259)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (40208236..40211981)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables adenosine 5'-monophosphoramidase activity	ISO Inferred from Sequence Orthology more info
enables adenosine 5'-monophosphoramidase activity	ISS Inferred from Sequence or Structural Similarity more info
enables deSUMOylase activity	ISO Inferred from Sequence Orthology more info
enables deSUMOylase activity	ISS Inferred from Sequence or Structural Similarity more info
enables hydrolase activity	IBA Inferred from Biological aspect of Ancestor more info
enables hydrolase activity	ISO Inferred from Sequence Orthology more info
enables hydrolase activity	ISS Inferred from Sequence or Structural Similarity more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in intrinsic apoptotic signaling pathway by p53 class mediator	ISO Inferred from Sequence Orthology more info
involved_in intrinsic apoptotic signaling pathway by p53 class mediator	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of calcium-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in protein desumoylation	ISO Inferred from Sequence Orthology more info
involved_in protein desumoylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in purine ribonucleotide catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in purine ribonucleotide catabolic process	ISO Inferred from Sequence Orthology more info
involved_in purine ribonucleotide catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
part_of histone deacetylase complex	ISO Inferred from Sequence Orthology more info
part_of histone deacetylase complex	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: adenosine 5'-monophosphoramidase HINT1

Names: 17 kDa inhibitor of protein kinase C; PKCI-1; adenosine 5'-monophosphoramidase; desumoylating isopeptidase HINT1; protein kinase C inhibitor 1; protein kinase C, iota; protein kinase C-interacting protein 1

NP_001103077.1

EC 3.-.-.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001109607.1 → NP_001103077.1 adenosine 5'-monophosphoramidase HINT1

See identical proteins and their annotated locations for NP_001103077.1

Status: PROVISIONAL

Source sequence(s)

CH473948

UniProtKB/Swiss-Prot

B5DEM9, P62959

UniProtKB/TrEMBL

D4A269

Related

ENSRNOP00000102416.1, ENSRNOT00000165419.1

Conserved Domains (1) summary

cd01276
Location:16 → 118

PKCI_related; Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a ...