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    Kcns2 potassium voltage-gated channel, modifier subfamily S, member 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 66022, updated on 9-Dec-2024

    Summary

    Official Symbol
    Kcns2provided by RGD
    Official Full Name
    potassium voltage-gated channel, modifier subfamily S, member 2provided by RGD
    Primary source
    RGD:621525
    See related
    EnsemblRapid:ENSRNOG00000066111 AllianceGenome:RGD:621525
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable potassium channel regulator activity. Predicted to be involved in action potential; potassium ion transmembrane transport; and regulation of delayed rectifier potassium channel activity. Predicted to be located in perinuclear region of cytoplasm and plasma membrane. Predicted to be part of voltage-gated potassium channel complex. Predicted to be active in membrane. Orthologous to human KCNS2 (potassium voltage-gated channel modifier subfamily S member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 58.5), Testes (RPKM 13.6) and 1 other tissue See more
    Orthologs
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    Genomic context

    See Kcns2 in Genome Data Viewer
    Location:
    7q22
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (67907492..67913562)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (66022352..66028422)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (73559226..73590385)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479602 Neighboring gene uncharacterized LOC102553465 Neighboring gene serine/threonine kinase 3 Neighboring gene odd-skipped related transciption factor 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables potassium channel regulator activity  
    enables potassium channel regulator activity  
    enables potassium channel regulator activity  
    enables voltage-gated potassium channel activity  
    Process Evidence Code Pubs
    involved_in action potential  
    involved_in potassium ion transmembrane transport  
    involved_in potassium ion transport  
    involved_in potassium ion transport  
    involved_in protein homooligomerization  
    involved_in regulation of potassium ion transmembrane transport  
    involved_in regulation of potassium ion transmembrane transport  
    Component Evidence Code Pubs
    is_active_in membrane  
    located_in perinuclear region of cytoplasm  
    located_in perinuclear region of cytoplasm  
    located_in plasma membrane  
    located_in plasma membrane  
    part_of voltage-gated potassium channel complex  
    part_of voltage-gated potassium channel complex  
    part_of voltage-gated potassium channel complex  

    General protein information

    Preferred Names
    delayed-rectifier potassium channel regulatory subunit KCNS2
    Names
    delayed-rectifier K(+) channel alpha subunit 2
    delayed-rectifier potassium channel subunit Kv9.2
    potassium channel, alpha subunit (kv9.2 gene)
    potassium voltage-gated channel subfamily S member 2
    potassium voltage-gated channel, delayed-rectifier, subfamily S, member 2
    voltage-gated potassium channel subunit Kv9.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_023966.2NP_076456.1  delayed-rectifier potassium channel regulatory subunit KCNS2

      See identical proteins and their annotated locations for NP_076456.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/Swiss-Prot
      Q9ER26
      UniProtKB/TrEMBL
      A6HR10
      Related
      ENSRNOP00000101618.1, ENSRNOT00000122496.1
      Conserved Domains (2) summary
      cd18427
      Location:18124
      BTB_POZ_KCNS2; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily S member 2 (KCNS2)
      pfam00520
      Location:186421
      Ion_trans; Ion transport protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      67907492..67913562
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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