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    Ccnd3 cyclin D3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25193, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ccnd3provided by RGD
    Official Full Name
    cyclin D3provided by RGD
    Primary source
    RGD:2293
    See related
    EnsemblRapid:ENSRNOG00000050258 AllianceGenome:RGD:2293
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables protein kinase binding activity. Involved in several processes, including G1/S transition of mitotic cell cycle; hyaluronan biosynthetic process; and response to glucose. Predicted to be located in nucleoplasm. Predicted to be part of cyclin D3-CDK4 complex and cyclin D3-CDK6 complex. Predicted to be active in cytoplasm; microtubule organizing center; and nucleus. Orthologous to human CCND3 (cyclin D3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 899.5), Adrenal (RPKM 427.4) and 8 other tissues See more
    Orthologs
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    Genomic context

    See Ccnd3 in Genome Data Viewer
    Location:
    9q12
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (20891696..20987199, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (13394161..13400341, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (15404816..15410905, complement)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene ubiquitin specific peptidase 49 Neighboring gene mediator complex subunit 20 Neighboring gene bystin-like Neighboring gene uncharacterized LOC134480552 Neighboring gene uncharacterized LOC134480554 Neighboring gene TATA-box binding protein associated factor 8 Neighboring gene similar to human chromosome 6 open reading frame 132 Neighboring gene ciliary microtubule inner protein 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • MGC93643, MGC108760

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in G1/S transition of mitotic cell cycle  
    involved_in G1/S transition of mitotic cell cycle  
    involved_in G1/S transition of mitotic cell cycle PubMed 
    involved_in G1/S transition of mitotic cell cycle  
    involved_in T cell proliferation  
    acts_upstream_of_or_within T cell proliferation  
    involved_in cell division  
    involved_in hyaluronan biosynthetic process PubMed 
    involved_in negative regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II  
    involved_in positive regulation of G1/S transition of mitotic cell cycle  
    involved_in positive regulation of cell population proliferation PubMed 
    involved_in positive regulation of cyclin-dependent protein serine/threonine kinase activity  
    involved_in positive regulation of protein phosphorylation  
    involved_in regulation of cell cycle  
    acts_upstream_of_or_within regulation of cell cycle  
    involved_in regulation of cell population proliferation  
    acts_upstream_of_or_within regulation of cell population proliferation  
    involved_in response to glucose PubMed 
    involved_in response to peptide hormone PubMed 
    involved_in signal transduction  
    acts_upstream_of_or_within signal transduction  
    Component Evidence Code Pubs
    part_of cyclin D3-CDK4 complex  
    part_of cyclin D3-CDK4 complex  
    part_of cyclin D3-CDK6 complex  
    part_of cyclin D3-CDK6 complex  
    part_of cyclin-dependent protein kinase holoenzyme complex  
    part_of cyclin-dependent protein kinase holoenzyme complex  
    is_active_in cytoplasm  
    is_active_in microtubule organizing center  
    located_in nucleoplasm  
    located_in nucleoplasm  
    is_active_in nucleus  
    located_in nucleus  

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012766.3NP_036898.2  G1/S-specific cyclin-D3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/Swiss-Prot
      P48961, Q63628
      UniProtKB/TrEMBL
      M0R5N2, Q5U321
      Conserved Domains (1) summary
      cl40454
      Location:2151
      CYCLIN_SF; Cyclin box fold superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      20891696..20987199 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063266666.1XP_063122736.1  G1/S-specific cyclin-D3 isoform X1

      UniProtKB/Swiss-Prot
      P48961, Q63628
      UniProtKB/TrEMBL
      M0R5N2, Q5U321
    2. XM_063266663.1XP_063122733.1  G1/S-specific cyclin-D3 isoform X1

      UniProtKB/Swiss-Prot
      P48961, Q63628
      UniProtKB/TrEMBL
      M0R5N2, Q5U321
      Related
      ENSRNOP00000064704.1, ENSRNOT00000074217.3
    3. XM_063266665.1XP_063122735.1  G1/S-specific cyclin-D3 isoform X1

      UniProtKB/Swiss-Prot
      P48961, Q63628
      UniProtKB/TrEMBL
      M0R5N2, Q5U321
    4. XM_063266667.1XP_063122737.1  G1/S-specific cyclin-D3 isoform X1

      UniProtKB/Swiss-Prot
      P48961, Q63628
      UniProtKB/TrEMBL
      M0R5N2, Q5U321
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