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    Nutf2 nuclear transport factor 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 291981, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nutf2provided by RGD
    Official Full Name
    nuclear transport factor 2provided by RGD
    Primary source
    RGD:1359213
    See related
    EnsemblRapid:ENSRNOG00000018945 AllianceGenome:RGD:1359213
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    NTF2
    Summary
    Enables nuclear import signal receptor activity and small GTPase binding activity. Involved in negative regulation of vascular endothelial growth factor production; positive regulation of protein import into nucleus; and protein localization to nucleus. Located in cytosol and nuclear outer membrane. Part of nuclear pore central transport channel. Used to study diabetic retinopathy. Orthologous to human NUTF2 (nuclear transport factor 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 340.4), Heart (RPKM 243.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Nutf2 in Genome Data Viewer
    Location:
    19q12
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (50662168..50683457)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (33752319..33773595)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (37830917..37852192)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene translin-associated factor X interacting protein 1 Neighboring gene centromere protein T Neighboring gene THAP domain containing 11 Neighboring gene enhancer of mRNA decapping 4 Neighboring gene neuritin 1-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Crystallization and preliminary X-ray diffraction analysis of nuclear transport factor 2. Kent HM, et al. J Struct Biol, 1996 Mar-Apr. PMID 8812990
    2. Engineered mutants in the switch II loop of Ran define the contribution made by key residues to the interaction with nuclear transport factor 2 (NTF2) and the role of this interaction in nuclear protein import. Kent HM, et al. J Mol Biol, 1999 Jun 11. PMID 10356329
    3. Overexpression of nuclear transport factor 2 may protect against diabetic retinopathy. Li B, et al. Mol Vis, 2009. PMID 19404486, Free PMC Article
    4. Separate binding sites on nuclear transport factor 2 (NTF2) for GDP-Ran and the phenylalanine-rich repeat regions of nucleoporins p62 and Nsp1p. Clarkson WD, et al. J Mol Biol, 1996 Nov 8. PMID 8918934
    5. Monoclonal antibodies to NTF2 inhibit nuclear protein import by preventing nuclear translocation of the GTPase Ran. Steggerda SM, et al. Mol Biol Cell, 2000 Feb. PMID 10679025, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NTF2 is a potential mediator of retinal vasculature integrity.
      Title: Overexpression of nuclear transport factor 2 may protect against diabetic retinopathy.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC72930

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nuclear import signal receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nuclear import signal receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables small GTPase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables structural constituent of nuclear pore ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of vascular endothelial growth factor production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nucleocytoplasmic transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of protein import into nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein export from nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein import into nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein import into nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein import into nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to nuclear pore IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear outer membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of nuclear pore IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of nuclear pore central transport channel IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of nuclear pore central transport channel IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    nuclear transport factor 2
    Names
    NTF-2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007629.2 → NP_001007630.1  nuclear transport factor 2

      See identical proteins and their annotated locations for NP_001007630.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/Swiss-Prot
      P61972
      UniProtKB/TrEMBL
      A0A8L2QDH9, A6IYT2
      Conserved Domains (1) summary
      cd00780
      Location:7 → 122
      NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      50662168..50683457
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006255480.5 → XP_006255542.1  nuclear transport factor 2 isoform X1

      See identical proteins and their annotated locations for XP_006255542.1

      UniProtKB/Swiss-Prot
      P61972
      UniProtKB/TrEMBL
      A0A8L2QDH9, A6IYT2
      Related
      ENSRNOP00000025608.5, ENSRNOT00000025608.6
      Conserved Domains (1) summary
      cd00780
      Location:7 → 122
      NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...

    2. XM_039097626.2 → XP_038953554.1  nuclear transport factor 2 isoform X1

      UniProtKB/Swiss-Prot
      P61972
      UniProtKB/TrEMBL
      A0A8L2QDH9, A6IYT2
      Conserved Domains (1) summary
      cd00780
      Location:7 → 122
      NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...

    3. XM_039097625.1 → XP_038953553.1  nuclear transport factor 2 isoform X1

      UniProtKB/Swiss-Prot
      P61972
      UniProtKB/TrEMBL
      A0A8L2QDH9, A6IYT2
      Conserved Domains (1) summary
      cd00780
      Location:7 → 122
      NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...

    4. XM_039097624.1 → XP_038953552.1  nuclear transport factor 2 isoform X1

      UniProtKB/Swiss-Prot
      P61972
      UniProtKB/TrEMBL
      A0A8L2QDH9, A6IYT2
      Conserved Domains (1) summary
      cd00780
      Location:7 → 122
      NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P61972.1 GenPept UniProtKB/Swiss-Prot:P61972

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