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    Tbc1d10a TBC1 domain family, member 10a [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360968, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tbc1d10aprovided by RGD
    Official Full Name
    TBC1 domain family, member 10aprovided by RGD
    Primary source
    RGD:1311641
    See related
    EnsemblRapid:ENSRNOG00000006394 AllianceGenome:RGD:1311641
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Tbc1d10
    Summary
    Predicted to enable GTPase activator activity and PDZ domain binding activity. Predicted to be involved in activation of cysteine-type endopeptidase activity and retrograde transport, endosome to Golgi. Predicted to be located in cytosol. Predicted to be active in cytoplasm and plasma membrane. Orthologous to human TBC1D10A (TBC1 domain family member 10A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 202.7), Lung (RPKM 119.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tbc1d10a in Genome Data Viewer
    Location:
    14q21
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (83278151..83307178)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (79051822..79083603)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (84417320..84445034)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481866 Neighboring gene coiled-coil domain containing 157 Neighboring gene splicing factor 3A subunit 1 Neighboring gene cytosolic arginine sensor for mTORC1 subunit 1 Neighboring gene oncostatin M

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of EPI64, a TBC/rabGAP domain-containing microvillar protein that binds to the first PDZ domain of EBP50 and E3KARP. Reczek D, et al. J Cell Biol, 2001 Apr 2. PMID 11285285, Free PMC Article
    2. A pathway sensor for genome-wide screens of intracellular proteolytic cleavage. Ketteler R, et al. Genome Biol, 2008 Apr 3. PMID 18387192, Free PMC Article
    3. Specific Rab GTPase-activating proteins define the Shiga toxin and epidermal growth factor uptake pathways. Fuchs E, et al. J Cell Biol, 2007 Jun 18. PMID 17562788, Free PMC Article
    4. Functional dissection of Rab GTPases involved in primary cilium formation. Yoshimura S, et al. J Cell Biol, 2007 Jul 30. PMID 17646400, Free PMC Article
    5. E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Guo Z, et al. Sci Signal, 2014 Dec 2. PMID 25468996, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC105611

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables PDZ domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in activation of cysteine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of proteolysis ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT involved_in regulation of cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in retrograde transport, endosome to Golgi IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in retrograde transport, endosome to Golgi ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    TBC1 domain family member 10A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001015022.4 → NP_001015022.1  TBC1 domain family member 10A

      See identical proteins and their annotated locations for NP_001015022.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      F7EVS3, Q566D9, Q587K3
      Related
      ENSRNOP00000099097.1, ENSRNOT00000163364.1
      Conserved Domains (2) summary
      smart00164
      Location:110 → 313
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      PHA03247
      Location:377 → 500
      PHA03247; large tegument protein UL36; Provisional

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      83278151..83307178
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039092211.2 → XP_038948139.1  TBC1 domain family member 10A isoform X1

      Conserved Domains (2) summary
      smart00164
      Location:22 → 225
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      PHA03247
      Location:289 → 412
      PHA03247; large tegument protein UL36; Provisional
    Nucleotide Protein Strain
    Heading Accession and Version

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