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    Cables1 Cdk5 and Abl enzyme substrate 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 307585, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cables1provided by RGD
    Official Full Name
    Cdk5 and Abl enzyme substrate 1provided by RGD
    Primary source
    RGD:1305516
    See related
    EnsemblRapid:ENSRNOG00000012795 AllianceGenome:RGD:1305516
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in nervous system development. Predicted to be active in cytosol. Orthologous to human CABLES1 (Cdk5 and Abl enzyme substrate 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 87.9), Brain (RPKM 53.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cables1 in Genome Data Viewer
    Location:
    18p13
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (3349681..3455956)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (3076556..3181181)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (3317724..3421721)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene U6 snRNA-associated Sm-like protein LSm3 Neighboring gene RB binding protein 8, endonuclease Neighboring gene uncharacterized LOC134482975 Neighboring gene solute carrier family 25 member 19, pseudogene 1 Neighboring gene transmembrane protein 241 Neighboring gene uncharacterized LOC120098160 Neighboring gene small nucleolar RNA SNORA17

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cables links Cdk5 and c-Abl and facilitates Cdk5 tyrosine phosphorylation, kinase upregulation, and neurite outgrowth. Zukerberg LR, et al. Neuron, 2000 Jun. PMID 10896159
    2. NESH (Abi-3) is present in the Abi/WAVE complex but does not promote c-Abl-mediated phosphorylation. Hirao N, et al. FEBS Lett, 2006 Nov 27. PMID 17101133
    3. Sequential Elution Interactome Analysis of the Mind Bomb 1 Ubiquitin Ligase Reveals a Novel Role in Dendritic Spine Outgrowth. Mertz J, et al. Mol Cell Proteomics, 2015 Jul. PMID 25931508, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within nervous system development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    CDK5 and ABL1 enzyme substrate 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107404.2 → NP_001100874.2  CDK5 and ABL1 enzyme substrate 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000018
      UniProtKB/TrEMBL
      A6KNG0, F1LUR9
      Related
      ENSRNOP00000017187.7, ENSRNOT00000017187.8

    2. NM_001415691.1 → NP_001402620.1  CDK5 and ABL1 enzyme substrate 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000018
      UniProtKB/TrEMBL
      A0A8I6AIM6, A6KNG0
      Related
      ENSRNOP00000094903.1, ENSRNOT00000104819.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      3349681..3455956
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039096929.2 → XP_038952857.1  CDK5 and ABL1 enzyme substrate 1 isoform X1

    2. XM_039096930.2 → XP_038952858.1  CDK5 and ABL1 enzyme substrate 1 isoform X1

    3. XM_063277454.1 → XP_063133524.1  CDK5 and ABL1 enzyme substrate 1 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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