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    Myh1 myosin heavy chain 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 287408, updated on 9-Dec-2024

    Summary

    Official Symbol
    Myh1provided by RGD
    Official Full Name
    myosin heavy chain 1provided by RGD
    Primary source
    RGD:735061
    See related
    EnsemblRapid:ENSRNOG00000083924 AllianceGenome:RGD:735061
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    MYHC
    Summary
    Predicted to enable ATP hydrolysis activity and microfilament motor activity. Involved in muscle contraction. Part of muscle myosin complex. Orthologous to human MYH1 (myosin heavy chain 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 38815.6) See more
    Orthologs
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    Genomic context

    See Myh1 in Genome Data Viewer
    Location:
    10q24
    Exon count:
    40
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (52384810..52408698)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (51885913..51909699)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (53740841..53764610)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480700 Neighboring gene myosin heavy chain 2 Neighboring gene uncharacterized LOC102555216 Neighboring gene myosin heavy chain 4 Neighboring gene myosin heavy chain 8

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding  
    enables ATP hydrolysis activity PubMed 
    enables actin filament binding  
    enables calmodulin binding  
    enables microfilament motor activity PubMed 
    Component Evidence Code Pubs
    located_in A band  
    located_in cytoplasmic ribonucleoprotein granule  
    located_in intercalated disc  
    part_of muscle myosin complex PubMed 
    part_of muscle myosin complex  
    located_in myosin filament  

    General protein information

    Preferred Names
    myosin, heavy polypeptide 1, skeletal muscle, adult
    Names
    myosin, heavy chain 1, skeletal muscle, adult
    type 2X myosin heavy chain

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001135158.1NP_001128630.1  myosin, heavy polypeptide 1, skeletal muscle, adult

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      F1LRV9
      Related
      ENSRNOP00000004295.7, ENSRNOT00000004295.8
      Conserved Domains (3) summary
      cd14910
      Location:100773
      MYSc_Myh1_mammals; class II myosin heavy chain 1, motor domain
      pfam01576
      Location:8531930
      Myosin_tail_1; Myosin tail
      pfam02736
      Location:3573
      Myosin_N; Myosin N-terminal SH3-like domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      52384810..52408698
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039085434.2XP_038941362.1  myosin, heavy polypeptide 1, skeletal muscle, adult isoform X1

      UniProtKB/TrEMBL
      F1LRV9
      Conserved Domains (3) summary
      cd14910
      Location:100773
      MYSc_Myh1_mammals; class II myosin heavy chain 1, motor domain
      pfam01576
      Location:8531930
      Myosin_tail_1; Myosin tail
      pfam02736
      Location:3573
      Myosin_N; Myosin N-terminal SH3-like domain
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