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    Mrps14 mitochondrial ribosomal protein S14 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 289143, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mrps14provided by RGD
    Official Full Name
    mitochondrial ribosomal protein S14provided by RGD
    Primary source
    RGD:1309432
    See related
    EnsemblRapid:ENSRNOG00000079901 AllianceGenome:RGD:1309432
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be a structural constituent of ribosome. Predicted to be involved in mitochondrial translation. Predicted to be located in mitochondrion and nuclear membrane. Predicted to be part of mitochondrial small ribosomal subunit. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 38. Orthologous to human MRPS14 (mitochondrial ribosomal protein S14). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 231.5), Muscle (RPKM 231.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mrps14 in Genome Data Viewer
    Location:
    13q22
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (74962597..74968344)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (72429168..72434915)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (77940454..77946201)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene KIAA0040 ortholog Neighboring gene tenascin N Neighboring gene uncharacterized LOC120096295 Neighboring gene uncharacterized LOC134481579 Neighboring gene calcyclin binding protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A variant in MRPS14 (uS14m) causes perinatal hypertrophic cardiomyopathy with neonatal lactic acidosis, growth retardation, dysmorphic features and neurological involvement. Jackson CB, et al. Hum Mol Genet, 2019 Feb 15. PMID 30358850
    2. Ribosome. The structure of the human mitochondrial ribosome. Amunts A, et al. Science, 2015 Apr 3. PMID 25838379, Free PMC Article
    3. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853
    4. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
    5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of mitochondrial small ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mitochondrial small ribosomal subunit ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    small ribosomal subunit protein uS14m
    Names
    28S ribosomal protein S14, mitochondrial
    NP_001099433.1
    XP_006250160.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001105963.3 → NP_001099433.1  small ribosomal subunit protein uS14m

      See identical proteins and their annotated locations for NP_001099433.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/TrEMBL
      A0A8I6AAC9, B2RYT4, F7F3Q8
      Conserved Domains (1) summary
      pfam00253
      Location:74 → 126
      Ribosomal_S14; Ribosomal protein S14p/S29e

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      74962597..74968344
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006250098.5 → XP_006250160.1  small ribosomal subunit protein uS14m isoform X1

      UniProtKB/TrEMBL
      A0A8I6AMX3, F7F3Q8
      Related
      ENSRNOP00000099935.1, ENSRNOT00000164241.1
      Conserved Domains (1) summary
      pfam00253
      Location:72 → 124
      Ribosomal_S14; Ribosomal protein S14p/S29e
    Nucleotide Protein Strain
    Heading Accession and Version

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