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    Fry FRY microtubule binding protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 304244, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Fryprovided by RGD
    Official Full Name
    FRY microtubule binding proteinprovided by RGD
    Primary source
    RGD:1307034
    See related
    EnsemblRapid:ENSRNOG00000000894 AllianceGenome:RGD:1307034
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1307034
    Summary
    Predicted to enable enzyme inhibitor activity. Predicted to be involved in cell morphogenesis; negative regulation of tubulin deacetylation; and neuron projection development. Predicted to be active in cell cortex and site of polarized growth. Orthologous to human FRY (FRY microtubule binding protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 272.0), Muscle (RPKM 215.7) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Fry in Genome Data Viewer
    Location:
    12p12
    Exon count:
    63
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (9530360..9773391, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (4493890..4887118, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (5573729..5822874, complement)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein S29, pseudogene 3 Neighboring gene uncharacterized LOC134481256 Neighboring gene uncharacterized LOC102546827 Neighboring gene translationally-controlled tumor protein-like Neighboring gene long non-coding RNA 001

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Furry promotes acetylation of microtubules in the mitotic spindle by inhibition of SIRT2 tubulin deacetylase. Nagai T, et al. J Cell Sci, 2013 Oct 1. PMID 23886946
    2. p38α MAPK proximity assay reveals a regulatory mechanism of alternative splicing in cardiomyocytes. Dumont AA, et al. Biochim Biophys Acta Mol Cell Res, 2019 Dec. PMID 31505169
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables enzyme inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of tubulin deacetylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neuron projection development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell cortex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in site of polarized growth IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein furry homolog
    Names
    furry homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001170398.2 → NP_001163869.2  protein furry homolog

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/TrEMBL
      C0IXW5, C0IXW6
      Related
      ENSRNOP00000078308.2, ENSRNOT00000115347.3
      Conserved Domains (3) summary
      pfam14228
      Location:1140 → 1505
      MOR2-PAG1_mid; Cell morphogenesis central region
      pfam14222
      Location:165 → 671
      MOR2-PAG1_N; Cell morphogenesis N-terminal
      pfam14225
      Location:2041 → 2294
      MOR2-PAG1_C; Cell morphogenesis C-terminal

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      9530360..9773391 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039089331.2 → XP_038945259.1  protein furry homolog isoform X1

      UniProtKB/TrEMBL
      A0A8I6G1L6
      Related
      ENSRNOP00000109373.1, ENSRNOT00000140530.1
      Conserved Domains (3) summary
      pfam14228
      Location:1140 → 1505
      MOR2-PAG1_mid; Cell morphogenesis central region
      pfam14222
      Location:165 → 671
      MOR2-PAG1_N; Cell morphogenesis N-terminal
      pfam14225
      Location:2041 → 2294
      MOR2-PAG1_C; Cell morphogenesis C-terminal

    2. XM_063271250.1 → XP_063127320.1  protein furry homolog isoform X3

      UniProtKB/TrEMBL
      A0A0G2K749

    3. XM_063271249.1 → XP_063127319.1  protein furry homolog isoform X2

      UniProtKB/TrEMBL
      A0A0G2K749, A0A8I6A9Q5
    Nucleotide Protein Strain
    Heading Accession and Version

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    Molecular Biology Databases
    Research Materials