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    Ocrl OCRL, inositol polyphosphate-5-phosphatase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 317576, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ocrlprovided by RGD
    Official Full Name
    OCRL, inositol polyphosphate-5-phosphataseprovided by RGD
    Primary source
    RGD:1594526
    See related
    EnsemblRapid:ENSRNOG00000003875 AllianceGenome:RGD:1594526
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    OCRL-1
    Summary
    Predicted to enable GTPase activator activity; phosphatase activity; and small GTPase binding activity. Predicted to be involved in cilium assembly. Predicted to act upstream of or within in utero embryonic development and phosphatidylinositol dephosphorylation. Predicted to be located in several cellular components, including cytoplasmic vesicle; photoreceptor outer segment; and trans-Golgi network. Predicted to be active in cytoplasm; membrane; and neuron projection. Human ortholog(s) of this gene implicated in Dent disease 2 and oculocerebrorenal syndrome. Orthologous to human OCRL (OCRL inositol polyphosphate-5-phosphatase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 223.7), Brain (RPKM 85.1) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Ocrl in Genome Data Viewer
    Location:
    Xq35
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (131955775..132018298)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (127089508..127140362)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (134742226..134793411)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene SNF2 related chromatin remodeling ATPase 1 Neighboring gene karyopherin subunit alpha 1, pseudogene 7 Neighboring gene uncharacterized LOC134484146 Neighboring gene apelin Neighboring gene X-prolyl aminopeptidase 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in biological_process  
    involved_in cilium assembly  
    involved_in cilium assembly  
    involved_in in utero embryonic development  
    acts_upstream_of_or_within in utero embryonic development  
    involved_in phosphatidylinositol dephosphorylation  
    acts_upstream_of_or_within phosphatidylinositol dephosphorylation  
    involved_in signal transduction  
    Component Evidence Code Pubs
    located_in clathrin-coated pit  
    located_in clathrin-coated vesicle  
    located_in clathrin-coated vesicle  
    located_in clathrin-coated vesicle  
    is_active_in cytoplasm  
    located_in cytoplasm  
    located_in early endosome  
    located_in early endosome  
    located_in early endosome membrane  
    is_active_in membrane  
    is_active_in neuron projection  
    located_in nucleus  
    located_in nucleus  
    located_in phagocytic vesicle membrane  
    located_in photoreceptor outer segment  
    located_in photoreceptor outer segment  
    located_in plasma membrane  
    located_in plasma membrane  
    located_in trans-Golgi network  
    located_in trans-Golgi network  

    General protein information

    Preferred Names
    inositol polyphosphate 5-phosphatase OCRL
    Names
    inositol polyphosphate 5-phosphatase OCRL-1
    oculocerebrorenal syndrome of Lowe
    phosphatidylinositol 3,4,5-triphosphate 5-phosphatase
    NP_001101726.2
    XP_038955773.1
    XP_038955775.1
    XP_063136159.1
    XP_063136160.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108256.2NP_001101726.2  inositol polyphosphate 5-phosphatase OCRL

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/Swiss-Prot
      D3ZGS3
      Related
      ENSRNOP00000099089.1, ENSRNOT00000173666.1
      Conserved Domains (3) summary
      cd09093
      Location:238531
      INPP5c_INPP5B; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of Type II inositol polyphosphate 5-phosphatase I, Oculocerebrorenal syndrome of Lowe 1, and related proteins
      cd04380
      Location:666894
      RhoGAP_OCRL1; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in OCRL1-like proteins. OCRL1 (oculocerebrorenal syndrome of Lowe 1)-like proteins contain two conserved domains: a central inositol polyphosphate 5-phosphatase domain and ...
      cd13382
      Location:11115
      PH_OCRL1; oculocerebrorenal syndrome of Lowe 1 Pleckstrin homology-like domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      131955775..132018298
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063280090.1XP_063136160.1  inositol polyphosphate 5-phosphatase OCRL isoform X4

      UniProtKB/TrEMBL
      R9PXS2
    2. XM_063280089.1XP_063136159.1  inositol polyphosphate 5-phosphatase OCRL isoform X2

      UniProtKB/TrEMBL
      A0A8L2R5U9, A6JMP0
    3. XM_039099845.2XP_038955773.1  inositol polyphosphate 5-phosphatase OCRL isoform X1

      UniProtKB/Swiss-Prot
      D3ZGS3
      Related
      ENSRNOP00000072408.3, ENSRNOT00000082363.3
      Conserved Domains (3) summary
      cd09093
      Location:238531
      INPP5c_INPP5B; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of Type II inositol polyphosphate 5-phosphatase I, Oculocerebrorenal syndrome of Lowe 1, and related proteins
      cd04380
      Location:666886
      RhoGAP_OCRL1; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in OCRL1-like proteins. OCRL1 (oculocerebrorenal syndrome of Lowe 1)-like proteins contain two conserved domains: a central inositol polyphosphate 5-phosphatase domain and ...
      cd13382
      Location:11115
      PH_OCRL1; oculocerebrorenal syndrome of Lowe 1 Pleckstrin homology-like domain
    4. XM_039099847.1XP_038955775.1  inositol polyphosphate 5-phosphatase OCRL isoform X3

      Conserved Domains (3) summary
      cd09093
      Location:238531
      INPP5c_INPP5B; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of Type II inositol polyphosphate 5-phosphatase I, Oculocerebrorenal syndrome of Lowe 1, and related proteins
      cd13382
      Location:11115
      PH_OCRL1; oculocerebrorenal syndrome of Lowe 1 Pleckstrin homology-like domain
      cl02570
      Location:666701
      RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
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