Muc5b mucin 5B, oligomeric mucus/gel-forming [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Muc5bprovided by RGD
Official Full Name: mucin 5B, oligomeric mucus/gel-formingprovided by RGD
Primary source: RGD:1561983
See related: EnsemblRapid:ENSRNOG00000019846 AllianceGenome:RGD:1561983
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1561983
Summary: Predicted to act upstream of or within defense response to bacterium and regulation of macrophage activation. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be active in extracellular matrix and extracellular space. Biomarker of nasopharynx carcinoma. Human ortholog(s) of this gene implicated in bronchiolitis; idiopathic pulmonary fibrosis; interstitial lung disease 2; and urinary bladder cancer. Orthologous to human MUC5B (mucin 5B, oligomeric mucus/gel-forming). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 42.4) and Thymus (RPKM 5.7) See more
Orthologs: human mouse all
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Genomic context

Location:: 1q41

Exon count:: 49

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (206346400..206378367)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (196916861..196948830)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (214778459..214811237)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Frequency of distal airways Clara cells was maintained while mRNA levels for the mucin-encoding genes Muc5B and Muc5ac in lung homogenates increased 1.9 and 3.9 times at 60 days of Pneumocystis infection.
Title: Primary infection by Pneumocystis induces Notch-independent Clara cell mucin production in rat distal airways.

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General gene information

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Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
acts_upstream_of_or_within defense response to bacterium	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of macrophage activation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: mucin-5B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.