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    Igf2bp1 insulin-like growth factor 2 mRNA binding protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303477, updated on 9-Dec-2024

    Summary

    Official Symbol
    Igf2bp1provided by RGD
    Official Full Name
    insulin-like growth factor 2 mRNA binding protein 1provided by RGD
    Primary source
    RGD:708580
    See related
    EnsemblRapid:ENSRNOG00000006122 AllianceGenome:RGD:708580
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Imp1; ZBP1
    Summary
    Enables mRNA 3'-UTR binding activity. Involved in RNA localization and dendrite arborization. Located in axon; dendritic spine; and neuronal cell body. Orthologous to human IGF2BP1 (insulin like growth factor 2 mRNA binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 9.3), Kidney (RPKM 6.7) and 4 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Igf2bp1 in Genome Data Viewer
    Location:
    10q26
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (81405021..81447814, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (80908300..80951097, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (83774178..83823323, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L15, pseudogene 8 Neighboring gene uncharacterized LOC120095180 Neighboring gene proteasome assembly chaperone 4, pseudogene 2 Neighboring gene gastric inhibitory polypeptide Neighboring gene SNF8 subunit of ESCRT-II

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables N6-methyladenosine-containing RNA reader activity  
    enables N6-methyladenosine-containing RNA reader activity  
    enables RNA binding  
    enables mRNA 3'-UTR binding  
    enables mRNA 3'-UTR binding PubMed 
    enables mRNA 3'-UTR binding  
    enables mRNA 3'-UTR binding  
    enables mRNA 5'-UTR binding  
    enables mRNA binding  
    enables mRNA binding  
    enables translation regulator activity  
    Process Evidence Code Pubs
    involved_in CRD-mediated mRNA stabilization  
    involved_in CRD-mediated mRNA stabilization  
    involved_in CRD-mediated mRNA stabilization  
    involved_in RNA localization PubMed 
    involved_in dendrite arborization PubMed 
    involved_in mRNA transport  
    involved_in negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay  
    involved_in negative regulation of translation  
    involved_in nervous system development  
    acts_upstream_of_or_within neuronal stem cell population maintenance  
    acts_upstream_of_or_within pallium cell proliferation in forebrain  
    involved_in positive regulation of cytoplasmic translation  
    involved_in regulation of mRNA stability involved in response to stress  
    involved_in regulation of mRNA stability involved in response to stress  
    involved_in regulation of translation  
    Items 1 - 20 of 26
    Component Evidence Code Pubs
    part_of CRD-mediated mRNA stability complex  
    part_of CRD-mediated mRNA stability complex  
    located_in P-body  
    located_in P-body  
    located_in P-body  
    located_in axon PubMed 
    is_active_in cytoplasm  
    located_in cytoplasm  
    located_in cytoplasmic stress granule  
    located_in cytoplasmic stress granule  
    located_in cytoplasmic stress granule  
    is_active_in cytosol  
    located_in cytosol  
    located_in dendrite PubMed 
    located_in dendritic spine PubMed 
    located_in filopodium  
    located_in growth cone  
    located_in lamellipodium  
    located_in neuronal cell body PubMed 
    located_in nucleoplasm  
    located_in nucleoplasm  
    is_active_in nucleus  
    located_in nucleus  
    located_in perinuclear region of cytoplasm  
    part_of ribonucleoprotein complex  
    part_of ribonucleoprotein complex  
    Items 1 - 20 of 26

    General protein information

    Preferred Names
    insulin-like growth factor 2 mRNA-binding protein 1
    Names
    B-actin zipcode-binding protein 1
    IGF-II mRNA-binding protein 1
    IGF2 mRNA-binding protein 1
    IMP-1
    VICKZ family member 1
    insulin-like growth factor 2, binding protein 1
    rZBP-1
    zipcode-binding protein-1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175594.2NP_783184.1  insulin-like growth factor 2 mRNA-binding protein 1

      See identical proteins and their annotated locations for NP_783184.1

      Status: PROVISIONAL

      Source sequence(s)
      AF541940
      UniProtKB/Swiss-Prot
      B1WBP3, Q8CGX0
      UniProtKB/TrEMBL
      A0A8I6AN86
      Related
      ENSRNOP00000008139.3, ENSRNOT00000008139.7
      Conserved Domains (3) summary
      cd12625
      Location:177
      RRM1_IGF2BP1; RNA recognition motif 1 (RRM1) found in vertebrate insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1)
      cd12628
      Location:81156
      RRM2_IGF2BP1; RNA recognition motif 2 (RRM2) found in vertebrate insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1)
      cl00098
      Location:273369
      KH-I; K homology (KH) RNA-binding domain, type I

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      81405021..81447814 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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