Egr2 early growth response 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Egr2provided by RGD
Official Full Name: early growth response 2provided by RGD
Primary source: RGD:621608
See related: EnsemblRapid:ENSRNOG00000000640 AllianceGenome:RGD:621608
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Krox20
Summary: Enables HMG box domain binding activity. Involved in learning or memory; regulation of neuronal synaptic plasticity; and response to insulin. Predicted to be located in cytoplasm and nucleoplasm. Biomarker of middle cerebral artery infarction. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 1D; Charcot-Marie-Tooth disease type 3; Charcot-Marie-Tooth disease type 4E; and motor peripheral neuropathy. Orthologous to human EGR2 (early growth response 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 20.8), Lung (RPKM 7.6) and 7 other tissues See more
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 20p11

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (21050149..21055201, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (21051270..21056322, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (22452170..22461018, complement)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

COUP-TFII plays a role in cAMP-induced Schwann cell differentiation and in vitro myelination by up-regulating Krox20.
Title: COUP-TFII plays a role in cAMP-induced Schwann cell differentiation and in vitro myelination by up-regulating Krox20.
pregulation of Egr2 and Egr4 could demote the activation of JNK/c-JUN pathway and the expression of pro-inflammatory cytokines in MCAO rats, so that Egr2 and Egr4 might be potential targets for ischemic stroke in future
Title: Overexpression of Egr2 and Egr4 protects rat brains against ischemic stroke by downregulating JNK signaling pathway.
Analysis of consensus EGR-binding elements (EBEs) showed that the immediate early response 3 gene (IER3) is a novel transcriptional target gene of EGR2 as confirmed by the luciferase assay, electrophoretic mobility-shift assay (EMSA), chromatin immunoprecipitation (ChIP), and western blot analysis.
Title: EGR2 is a gonadotropin-induced survival factor that controls the expression of IER3 in ovarian granulosa cells.
The upregulation of Egr-2 may be involved in the subsequent glia cellular activation.
Title: Involvement of early growth response-2 (Egr-2) in lipopolysaccharide-induced neuroinflammation.
in Schwann cells NFAT upregulation of Krox-20 requires elevation of cAMP levels.
Title: Calcineurin-nuclear factor of activated T cells regulation of Krox-20 expression in Schwann cells requires elevation of intracellular cyclic AMP.
our results show that p38 primarily directs Schwann cell differentiation and peripheral myelination by regulating Krox-20 expression through its downstream effectors, MK2 and MSK-1/CREB, and transcription factors SCIP and Sox10.
Title: Mitogen-activated protein kinase p38 regulates Krox-20 to direct Schwann cell differentiation and peripheral myelination.
changes in transcription factor, c-Jun and krox-20, and integrin beta4 expression are temporally correlated with the process of demyelination, suggesting roles in regulating the myelin response to CNC injury
Title: c-Jun, krox-20, and integrin beta4 expression following chronic nerve compression injury.
IEG c-fos is unaffected by suppression of calcineurin activity, the plasticity-related genes Egr1/Zif268 and Egr2/Krox-20 are up-regulated, and genes encoding the orphan nuclear hormone receptors Nor1 and Nur77 are down-regulated.
Title: Inverse regulation of plasticity-related immediate early genes by calcineurin in hippocampal neurons.
Egr2 directly represses genes during myelination in conjunction with NAB corepressors
Title: Active gene repression by the Egr2.NAB complex during peripheral nerve myelination.
Data demonstrate that in rat Schwann cells, progesterone and its derivatives increase expression of Sox-10 and Krox-20, two transcription factors with a key role in Schwann cell physiology and myelination.
Title: Progesterone derivatives increase expression of Krox-20 and Sox-10 in rat Schwann cells.

Submit: New GeneRIF Correction See all GeneRIFs (14)

General gene information

Go to the top of the page Help

Markers

Egr2 (e-PCR), detects polymorphism
- UniSTS:547589

PMC85614P2 (e-PCR)
- UniSTS:273477

Egr2 (e-PCR), detects polymorphism
- UniSTS:238159

X06746 (e-PCR)
- UniSTS:125792

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA binding	TAS Traceable Author Statement more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISS Inferred from Sequence or Structural Similarity more info
enables HMG box domain binding	IPI Inferred from Physical Interaction more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II-specific DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables SUMO ligase activity	ISO Inferred from Sequence Orthology more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables transcription cis-regulatory region binding	ISO Inferred from Sequence Orthology more info
enables transcription cis-regulatory region binding	ISS Inferred from Sequence or Structural Similarity more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Schwann cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in Schwann cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in Schwann cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in aorta development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within brain segmentation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within facial nerve structural organization	ISO Inferred from Sequence Orthology more info
involved_in facial nerve structural organization	ISO Inferred from Sequence Orthology more info
involved_in facial nerve structural organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in fat cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within_negative_effect gene expression	ISO Inferred from Sequence Orthology more info
involved_in gene expression	ISO Inferred from Sequence Orthology more info
involved_in learning or memory	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within motor neuron axon guidance	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within myelination	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of Schwann cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of Schwann cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of myelination	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of myelination	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein export from nucleus	ISO Inferred from Sequence Orthology more info
involved_in protein export from nucleus	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein sumoylation	IEA Inferred from Electronic Annotation more info
involved_in protein sumoylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in regulation of neuronal synaptic plasticity	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within regulation of ossification	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to insulin	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within rhombomere 3 development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within rhombomere 3 formation	ISO Inferred from Sequence Orthology more info
involved_in rhombomere 3 structural organization	ISO Inferred from Sequence Orthology more info
involved_in rhombomere 3 structural organization	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within rhombomere 5 formation	ISO Inferred from Sequence Orthology more info
involved_in rhombomere 5 structural organization	ISO Inferred from Sequence Orthology more info
involved_in rhombomere 5 structural organization	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within rhythmic behavior	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within skeletal muscle cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in skeletal muscle cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in skeletal muscle cell differentiation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

Go to the top of the page Help

Preferred Names: E3 SUMO-protein ligase EGR2

Names: E3 SUMO-protein transferase ERG2; EGR-2; early growth response protein 2; zinc finger protein Krox-20

NP_446085.1

EC 2.3.2.-

XP_017457019.1

EC 2.3.2.-

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053633.2 → NP_446085.1 E3 SUMO-protein ligase EGR2

See identical proteins and their annotated locations for NP_446085.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000020

UniProtKB/Swiss-Prot

P51774, Q54AG4

UniProtKB/TrEMBL

A6JKW0, A6JKW1

Related

ENSRNOP00000000792.2, ENSRNOT00000000792.6

Conserved Domains (4) summary

COG5048
Location:365 → 421

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:339 → 361

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:337 → 361

zf-C2H2; Zinc finger, C2H2 type

pfam11928
Location:94 → 166

DUF3446; Domain of unknown function (DUF3446)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086038.1 Reference GRCr8

Range

21050149..21055201 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017601530.2 → XP_017457019.1 E3 SUMO-protein ligase EGR2 isoform X1

UniProtKB/TrEMBL

A6JKW2, Q9QYG4

Conserved Domains (5) summary

COG5048
Location:315 → 371

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:289 → 311

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:287 → 311

zf-C2H2; Zinc finger, C2H2 type

pfam11928
Location:44 → 116

DUF3446; Domain of unknown function (DUF3446)

pfam13465
Location:331 → 356

zf-H2C2_2; Zinc-finger double domain