U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    Ace angiotensin I converting enzyme [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24310, updated on 9-Dec-2024

    Summary

    Symbol
    Aceprovided by RGD
    Full Name
    angiotensin I converting enzymeprovided by RGD
    Primary source
    RGD:2493
    See related
    EnsemblRapid:ENSRNOG00000062101 AllianceGenome:RGD:2493
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Dcp1; CD143; StsRR92
    Summary
    Enables heterocyclic compound binding activity; metallopeptidase activity; and peptidyl-dipeptidase activity. Involved in several processes, including blood vessel diameter maintenance; negative regulation of transport; and response to corticosteroid. Located in several cellular components, including basal plasma membrane; brush border membrane; and sperm midpiece. Used to study several diseases, including artery disease (multiple); glomerulonephritis (multiple); kidney failure (multiple); lung disease (multiple); and proteinuria (multiple). Biomarker of several diseases, including artery disease (multiple); congenital diaphragmatic hernia; endomyocardial fibrosis; liver cirrhosis (multiple); and lung disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); gastrointestinal system cancer (multiple); heart valve disease (multiple); and lung disease (multiple). Orthologous to human ACE (angiotensin I converting enzyme). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 989.5), Testes (RPKM 175.9) and 2 other tissues See more
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Ace in Genome Data Viewer
    Location:
    10q32.1
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (91410129..91430246)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (90910316..90930437)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (94170766..94213831)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 Neighboring gene snurportin 1, pseudogene 1 Neighboring gene uncharacterized LOC120095193 Neighboring gene cytochrome b-561 Neighboring gene angiotensin I converting enzyme (peptidyl-dipeptidase A) 3 Neighboring gene potassium voltage-gated channel subfamily H member 6

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Items 1 - 25 of 37
    Function Evidence Code Pubs
    enables actin binding  
    enables bradykinin receptor binding  
    enables bradykinin receptor binding  
    enables calmodulin binding  
    enables carboxypeptidase activity  
    enables chloride ion binding  
    enables chloride ion binding  
    enables chloride ion binding  
    enables endopeptidase activity  
    enables exopeptidase activity  
    enables heterocyclic compound binding PubMed 
    enables metal ion binding  
    enables metallodipeptidase activity  
    enables metallodipeptidase activity  
    enables metallodipeptidase activity  
    enables metalloendopeptidase activity  
    enables metalloendopeptidase activity  
    enables metalloendopeptidase activity  
    enables metallopeptidase activity  
    enables metallopeptidase activity  
    enables metallopeptidase activity PubMed 
    enables metallopeptidase activity  
    enables mitogen-activated protein kinase binding  
    enables mitogen-activated protein kinase binding  
    enables mitogen-activated protein kinase kinase binding  
    enables mitogen-activated protein kinase kinase binding  
    enables peptidase activity PubMed 
    enables peptidase activity  
    enables peptidyl-dipeptidase activity  
    enables peptidyl-dipeptidase activity PubMed 
    enables peptidyl-dipeptidase activity  
    enables peptidyl-dipeptidase activity  
    enables peptidyl-dipeptidase activity  
    enables tripeptidyl-peptidase activity  
    enables tripeptidyl-peptidase activity  
    enables zinc ion binding  
    enables zinc ion binding  
    Items 1 - 25 of 37
    Items 1 - 25 of 91
    Process Evidence Code Pubs
    involved_in amyloid-beta metabolic process  
    involved_in amyloid-beta metabolic process  
    involved_in angiogenesis involved in coronary vascular morphogenesis PubMed 
    involved_in angiotensin maturation  
    involved_in angiotensin maturation  
    involved_in angiotensin maturation  
    involved_in angiotensin-activated signaling pathway  
    involved_in angiotensin-activated signaling pathway  
    involved_in animal organ regeneration PubMed 
    involved_in arachidonate secretion  
    involved_in arachidonate secretion  
    involved_in bradykinin catabolic process PubMed 
    involved_in bradykinin catabolic process  
    involved_in bradykinin catabolic process PubMed 
    involved_in bradykinin catabolic process  
    involved_in cell proliferation in bone marrow  
    involved_in cell proliferation in bone marrow  
    involved_in cellular response to aldosterone PubMed 
    involved_in cellular response to glucose stimulus PubMed 
    involved_in eating behavior PubMed 
    involved_in embryo development ending in birth or egg hatching PubMed 
    involved_in female pregnancy PubMed 
    involved_in heart contraction  
    acts_upstream_of_or_within heart contraction  
    involved_in hormone catabolic process  
    involved_in hormone catabolic process  
    involved_in hormone catabolic process  
    involved_in hormone metabolic process  
    involved_in hormone metabolic process  
    involved_in kidney development  
    involved_in kidney development PubMed 
    acts_upstream_of_or_within kidney development  
    involved_in kidney development  
    involved_in kidney development  
    involved_in lung alveolus development PubMed 
    involved_in lung development PubMed 
    involved_in male gonad development  
    involved_in male gonad development PubMed 
    involved_in male gonad development  
    involved_in negative regulation of D-glucose import PubMed 
    involved_in negative regulation of calcium ion import PubMed 
    involved_in negative regulation of gap junction assembly  
    involved_in negative regulation of gap junction assembly  
    involved_in negative regulation of gene expression  
    involved_in negative regulation of gene expression  
    involved_in neutrophil mediated immunity  
    acts_upstream_of_or_within neutrophil mediated immunity  
    involved_in peptide catabolic process PubMed 
    involved_in peptide catabolic process  
    involved_in peptide metabolic process PubMed 
    involved_in positive regulation of apoptotic process PubMed 
    involved_in positive regulation of blood pressure PubMed 
    involved_in positive regulation of neurogenesis PubMed 
    involved_in positive regulation of peptidyl-cysteine S-nitrosylation  
    involved_in positive regulation of peptidyl-cysteine S-nitrosylation  
    involved_in positive regulation of systemic arterial blood pressure  
    involved_in positive regulation of systemic arterial blood pressure  
    involved_in positive regulation of systemic arterial blood pressure PubMed 
    acts_upstream_of_or_within positive regulation of systemic arterial blood pressure  
    involved_in positive regulation of vasoconstriction PubMed 
    involved_in post-transcriptional regulation of gene expression  
    involved_in post-transcriptional regulation of gene expression  
    involved_in proteolysis  
    involved_in regulation of angiotensin metabolic process  
    involved_in regulation of angiotensin metabolic process  
    involved_in regulation of blood pressure PubMed 
    involved_in regulation of blood pressure  
    involved_in regulation of blood pressure PubMed 
    involved_in regulation of heart rate by cardiac conduction  
    involved_in regulation of heart rate by cardiac conduction  
    involved_in regulation of hematopoietic stem cell proliferation  
    involved_in regulation of hematopoietic stem cell proliferation  
    involved_in regulation of smooth muscle cell migration PubMed 
    involved_in regulation of synaptic plasticity  
    involved_in regulation of synaptic plasticity  
    involved_in regulation of synaptic plasticity  
    involved_in regulation of systemic arterial blood pressure by renin-angiotensin  
    involved_in regulation of systemic arterial blood pressure by renin-angiotensin  
    involved_in response to dexamethasone PubMed 
    involved_in response to hypoxia PubMed 
    involved_in response to laminar fluid shear stress PubMed 
    involved_in response to lipopolysaccharide PubMed 
    involved_in response to nutrient levels PubMed 
    involved_in response to thyroid hormone PubMed 
    involved_in response to xenobiotic stimulus PubMed 
    involved_in spermatogenesis  
    acts_upstream_of_or_within spermatogenesis  
    involved_in substance P catabolic process  
    involved_in substance P catabolic process  
    involved_in substance P catabolic process  
    involved_in vasoconstriction PubMed 
    Items 1 - 25 of 91
    Items 1 - 20 of 25
    Component Evidence Code Pubs
    located_in basal plasma membrane PubMed 
    located_in brush border membrane PubMed 
    located_in cytoplasm  
    located_in cytoplasm  
    located_in endosome  
    located_in endosome  
    located_in external side of plasma membrane  
    located_in external side of plasma membrane  
    located_in extracellular exosome  
    located_in extracellular exosome  
    located_in extracellular region  
    located_in extracellular space PubMed 
    is_active_in extracellular space  
    located_in extracellular space  
    is_active_in extracellular space  
    located_in lysosome  
    located_in lysosome  
    located_in membrane  
    is_active_in plasma membrane  
    located_in plasma membrane  
    is_active_in plasma membrane  
    located_in plasma membrane  
    is_active_in plasma membrane  
    located_in sperm midpiece PubMed 
    located_in vesicle PubMed 
    Items 1 - 20 of 25

    General protein information

    Preferred Names
    angiotensin-converting enzyme
    Names
    Dipeptidyl carboxypeptidase 1 (Angiotensin I-converting enzyme)
    angiotensin 1 converting enzyme 1
    angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
    angiotensin I converting enzyme 1
    angiotensin I-converting enzyme (Dipeptidyl carboxypeptidase 1)
    angiotensin-converting enzyme-like
    dipeptidyl carboxypeptidase I
    kininase II
    NP_036676.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012544.1NP_036676.1  angiotensin-converting enzyme precursor

      See identical proteins and their annotated locations for NP_036676.1

      Status: PROVISIONAL

      Source sequence(s)
      U03734
      UniProtKB/Swiss-Prot
      P47820, Q7TMC6, Q8CFN1, Q9EQM9
      UniProtKB/TrEMBL
      A6HJZ3
      Related
      ENSRNOP00000084667.2, ENSRNOT00000119881.2
      Conserved Domains (1) summary
      pfam01401
      Location:6501227
      Peptidase_M2; Angiotensin-converting enzyme

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      91410129..91430246
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    External link. Please review our privacy policy.