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    Zfp598 zinc finger protein 598 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 287119, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zfp598provided by RGD
    Official Full Name
    zinc finger protein 598provided by RGD
    Primary source
    RGD:1304900
    See related
    EnsemblRapid:ENSRNOG00000012434 AllianceGenome:RGD:1304900
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ntrap; Znf598
    Summary
    Predicted to enable several functions, including ribosome binding activity; stalled ribosome sensor activity; and ubiquitin protein ligase activity. Predicted to be involved in several processes, including protein ubiquitination; rescue of stalled ribosome; and ribosome-associated ubiquitin-dependent protein catabolic process. Predicted to be located in cytosol. Predicted to be active in cytosolic ribosome. Orthologous to human ZNF598 (zinc finger protein 598, E3 ubiquitin ligase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 141.7), Liver (RPKM 84.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zfp598 in Genome Data Viewer
    Location:
    10q12
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (14198763..14210773)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (13694224..13706235)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (14035114..14047100)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene NHERF family PDZ scaffold protein 2 Neighboring gene neuropeptide W Neighboring gene synaptogyrin 3 Neighboring gene growth factor, augmenter of liver regeneration

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Retrograde neurotrophic signaling requires a protein interacting with receptor tyrosine kinases via C2H2 zinc fingers. Fu X, et al. Mol Biol Cell, 2010 Jan 1. PMID 19864463, Free PMC Article
    2. Initiation of Quality Control during Poly(A) Translation Requires Site-Specific Ribosome Ubiquitination. Juszkiewicz S, et al. Mol Cell, 2017 Feb 16. PMID 28065601, Free PMC Article
    3. ZNF598 and RACK1 Regulate Mammalian Ribosome-Associated Quality Control Function by Mediating Regulatory 40S Ribosomal Ubiquitylation. Sundaramoorthy E, et al. Mol Cell, 2017 Feb 16. PMID 28132843, Free PMC Article
    4. Sequential Elution Interactome Analysis of the Mind Bomb 1 Ubiquitin Ligase Reveals a Novel Role in Dendritic Spine Outgrowth. Mertz J, et al. Mol Cell Proteomics, 2015 Jul. PMID 25931508, Free PMC Article
    5. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NTRAP regulates retrograde neurotrophic signaling by controlling the formation of signaling endosomes.
      Title: Retrograde neurotrophic signaling requires a protein interacting with receptor tyrosine kinases via C2H2 zinc fingers.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-RNA adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ribosome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ribosome binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables stalled ribosome sensor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-protein transferase regulator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of translational initiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K63-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein monoubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in rescue of stalled ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in rescue of stalled ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ribosome-associated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosolic ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 598

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001105770.1 → NP_001099240.1  zinc finger protein 598

      See identical proteins and their annotated locations for NP_001099240.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473948
      UniProtKB/TrEMBL
      A6HCV0
      Conserved Domains (1) summary
      COG5236
      Location:26 → 335
      COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      14198763..14210773
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039085356.2 → XP_038941284.1  zinc finger protein 598 isoform X1

      Conserved Domains (2) summary
      COG5236
      Location:26 → 325
      COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
      PRK12323
      Location:393 → 622
      PRK12323; DNA polymerase III subunit gamma/tau

    2. XM_039085357.2 → XP_038941285.1  zinc finger protein 598 isoform X2

      Conserved Domains (2) summary
      COG5236
      Location:26 → 335
      COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
      PRK12323
      Location:390 → 619
      PRK12323; DNA polymerase III subunit gamma/tau

    3. XM_006245934.5 → XP_006245996.1  zinc finger protein 598 isoform X3

      UniProtKB/TrEMBL
      D3ZR64
      Related
      ENSRNOP00000060223.3, ENSRNOT00000065827.4
      Conserved Domains (1) summary
      COG5236
      Location:26 → 325
      COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]

    4. XM_063268563.1 → XP_063124633.1  zinc finger protein 598 isoform X4

      Related
      ENSRNOP00000103560.1, ENSRNOT00000125633.1
    Nucleotide Protein Strain
    Heading Accession and Version

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