Adgrf1 adhesion G protein-coupled receptor F1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Adgrf1provided by RGD
Full Name: adhesion G protein-coupled receptor F1provided by RGD
Primary source: RGD:1310285
See related: EnsemblRapid:ENSRNOG00000062544 AllianceGenome:RGD:1310285
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Gpr110
Summary: Predicted to enable G protein-coupled receptor activity. Predicted to be involved in cell surface receptor signaling pathway. Predicted to act upstream of or within several processes, including memory; nervous system development; and positive regulation of CREB transcription factor activity. Predicted to be located in plasma membrane. Orthologous to human ADGRF1 (adhesion G protein-coupled receptor F1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 13.7), Testes (RPKM 5.8) and 3 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 9q13

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (25158198..25210744, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (17661258..17696359, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (20343730..20378686, complement)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in energy reserve metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in fat cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within memory	ISO Inferred from Sequence Orthology more info
involved_in neuron projection development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within neuron projection development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of CREB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in regulation of lipid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in synapse assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within synapse assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasmic vesicle	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: adhesion G protein-coupled receptor F1; adhesion G-protein coupled receptor F1

Names: G protein-coupled receptor 110

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001431183.1 → NP_001418112.1 adhesion G protein-coupled receptor F1 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000009

UniProtKB/TrEMBL

A0A8I6AIR1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086027.1 Reference GRCr8

Range

25158198..25210744 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063267885.1 → XP_063123955.1 adhesion G-protein coupled receptor F1 isoform X3
XM_039084503.2 → XP_038940431.1 adhesion G-protein coupled receptor F1 isoform X2

Related

ENSRNOP00000093180.1, ENSRNOT00000115168.2

Conserved Domains (4) summary

smart00303
Location:531 → 579

GPS; G-protein-coupled receptor proteolytic site domain

cd14964
Location:583 → 608

7tm_GPCRs; TM helix 1 [structural motif]

cl02507
Location:153 → 228

SEA; SEA domain

cl28897
Location:582 → 848

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
XM_039084502.2 → XP_038940430.1 adhesion G-protein coupled receptor F1 isoform X1

Conserved Domains (4) summary

smart00303
Location:537 → 585

GPS; G-protein-coupled receptor proteolytic site domain

cd14964
Location:589 → 614

7tm_GPCRs; TM helix 1 [structural motif]

cl02507
Location:159 → 234

SEA; SEA domain

cl28897
Location:588 → 854

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
XM_039084504.2 → XP_038940432.1 adhesion G-protein coupled receptor F1 isoform X4

Related

ENSRNOP00000107020.1, ENSRNOT00000140207.1

Conserved Domains (4) summary

smart00303
Location:509 → 557

GPS; G-protein-coupled receptor proteolytic site domain

cd14964
Location:561 → 586

7tm_GPCRs; TM helix 1 [structural motif]

cl02507
Location:131 → 206

SEA; SEA domain

cl28897
Location:560 → 826

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001106894.1: Suppressed sequence

Description

NM_001106894.1: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from human: GPR110 (GeneID:266977).