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    Cracr2b calcium release activated channel regulator 2B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 309112, updated on 9-Dec-2024

    Summary

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    Symbol
    Cracr2bprovided by RGD
    Full Name
    calcium release activated channel regulator 2Bprovided by RGD
    Primary source
    RGD:1560911
    See related
    EnsemblRapid:ENSRNOG00000019199 AllianceGenome:RGD:1560911
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Efcab4a; RGD1560911
    Summary
    Predicted to enable calcium ion binding activity. Predicted to be involved in store-operated calcium entry. Predicted to act upstream of or within regulation of store-operated calcium entry. Predicted to be located in cytoplasm. Orthologous to human CRACR2B (calcium release activated channel regulator 2B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 89.2), Kidney (RPKM 51.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cracr2b in Genome Data Viewer
    Location:
    1q41
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (205987957..205993515)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (196558407..196563961)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (214439810..214445876)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein lateral stalk subunit P2 Neighboring gene small nucleolar RNA, H/ACA box 52 Neighboring gene patatin-like phospholipase domain containing 2 Neighboring gene CD151 molecule (Raph blood group) Neighboring gene RNA polymerase II, I and III subunit L

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A novel EF-hand protein, CRACR2A, is a cytosolic Ca2+ sensor that stabilizes CRAC channels in T cells. Srikanth S, et al. Nat Cell Biol, 2010 May. PMID 20418871, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in store-operated calcium entry ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in store-operated calcium entry ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    EF-hand calcium-binding domain-containing protein 4A
    Names
    EF-hand calcium binding domain 4A
    EF-hand calcium-binding domain-containing protein 4A-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001127541.2 → NP_001121013.1  EF-hand calcium-binding domain-containing protein 4A

      See identical proteins and their annotated locations for NP_001121013.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      B0BNK9
      Conserved Domains (2) summary
      pfam08614
      Location:229 → 303
      ATG16; Autophagy protein 16 (ATG16)
      pfam13499
      Location:31 → 88
      EF-hand_7; EF-hand domain pair

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      205987957..205993515
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006230561.5 → XP_006230623.1  EF-hand calcium-binding domain-containing protein 4A isoform X1

      See identical proteins and their annotated locations for XP_006230623.1

      UniProtKB/Swiss-Prot
      B0BNK9
      Conserved Domains (2) summary
      pfam08614
      Location:229 → 303
      ATG16; Autophagy protein 16 (ATG16)
      pfam13499
      Location:31 → 88
      EF-hand_7; EF-hand domain pair

    2. XM_063264083.1 → XP_063120153.1  EF-hand calcium-binding domain-containing protein 4A isoform X1

      UniProtKB/Swiss-Prot
      B0BNK9

    3. XM_063264085.1 → XP_063120155.1  EF-hand calcium-binding domain-containing protein 4A isoform X1

      UniProtKB/Swiss-Prot
      B0BNK9

    4. XM_063264090.1 → XP_063120160.1  EF-hand calcium-binding domain-containing protein 4A isoform X1

      UniProtKB/Swiss-Prot
      B0BNK9

    5. XM_006230559.5 → XP_006230621.1  EF-hand calcium-binding domain-containing protein 4A isoform X1

      See identical proteins and their annotated locations for XP_006230621.1

      UniProtKB/Swiss-Prot
      B0BNK9
      Related
      ENSRNOP00000025964.4, ENSRNOT00000025964.7
      Conserved Domains (2) summary
      pfam08614
      Location:229 → 303
      ATG16; Autophagy protein 16 (ATG16)
      pfam13499
      Location:31 → 88
      EF-hand_7; EF-hand domain pair

    6. XM_039079038.2 → XP_038934966.1  EF-hand calcium-binding domain-containing protein 4A isoform X1

      UniProtKB/Swiss-Prot
      B0BNK9
      Conserved Domains (2) summary
      pfam08614
      Location:229 → 303
      ATG16; Autophagy protein 16 (ATG16)
      pfam13499
      Location:31 → 88
      EF-hand_7; EF-hand domain pair

    7. XM_039079062.2 → XP_038934990.1  EF-hand calcium-binding domain-containing protein 4A isoform X2

      UniProtKB/TrEMBL
      A6HXY9
      Conserved Domains (2) summary
      TIGR02168
      Location:40 → 205
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam08614
      Location:113 → 187
      ATG16; Autophagy protein 16 (ATG16)

    8. XM_039079078.2 → XP_038935006.1  EF-hand calcium-binding domain-containing protein 4A isoform X3

      Conserved Domains (1) summary
      PRK11448
      Location:55 → 147
      hsdR; type I restriction enzyme EcoKI subunit R; Provisional

    9. XM_039079053.2 → XP_038934981.1  EF-hand calcium-binding domain-containing protein 4A isoform X2

      UniProtKB/TrEMBL
      A6HXY9
      Conserved Domains (2) summary
      TIGR02168
      Location:40 → 205
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam08614
      Location:113 → 187
      ATG16; Autophagy protein 16 (ATG16)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B0BNK9.1 GenPept UniProtKB/Swiss-Prot:B0BNK9

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