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    Ruvbl1 RuvB-like AAA ATPase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 65137, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ruvbl1provided by RGD
    Official Full Name
    RuvB-like AAA ATPase 1provided by RGD
    Primary source
    RGD:68373
    See related
    EnsemblRapid:ENSRNOG00000013195 AllianceGenome:RGD:68373
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    NMP238; Tip49a; Pontin52
    Summary
    Enables 3'-5' DNA helicase activity. Involved in positive regulation of plasminogen activation and regulation of fibroblast apoptotic process. Located in nuclear matrix. Part of protein-containing complex. Orthologous to human RUVBL1 (RuvB like AAA ATPase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 195.7), Spleen (RPKM 147.1) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Ruvbl1 in Genome Data Viewer
    Location:
    4q34
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (122489754..122524666)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (120932486..120967400)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (120411917..120447458)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA29 Neighboring gene uncharacterized LOC120102335 Neighboring gene eukaryotic elongation factor, selenocysteine-tRNA-specific Neighboring gene ribosomal protein S25 like 3 Neighboring gene SEC61 translocon subunit alpha 1 Neighboring gene kelch repeat and BTB domain containing 12

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 3'-5' DNA helicase activity PubMed 
    enables ADP binding  
    enables ATP binding  
    enables ATP binding  
    enables ATP hydrolysis activity  
    enables ATP hydrolysis activity  
    enables ATP-dependent H2AZ histone chaperone activity  
    enables ATP-dependent H3-H4 histone complex chaperone activity  
    enables ATP-dependent activity, acting on DNA  
    enables ATPase binding  
    enables DNA clamp loader activity  
    enables DNA helicase activity  
    enables DNA helicase activity  
    enables TBP-class protein binding  
    enables TFIID-class transcription factor complex binding  
    enables chromatin extrusion motor activity  
    enables cohesin loader activity  
    enables double-stranded DNA helicase activity  
    enables forked DNA-dependent helicase activity  
    enables four-way junction helicase activity  
    enables helicase activity  
    enables hydrolase activity  
    enables single-stranded 3'-5' DNA helicase activity  
    enables transcription coactivator activity  
    Process Evidence Code Pubs
    involved_in DNA duplex unwinding  
    involved_in DNA recombination  
    involved_in DNA repair  
    involved_in box C/D snoRNP assembly  
    involved_in cell division  
    involved_in chromatin looping  
    involved_in chromatin remodeling  
    involved_in chromatin remodeling  
    involved_in positive regulation of DNA repair  
    involved_in positive regulation of DNA-templated transcription  
    involved_in positive regulation of canonical Wnt signaling pathway  
    involved_in positive regulation of double-strand break repair via homologous recombination  
    involved_in positive regulation of plasminogen activation PubMed 
    involved_in positive regulation of telomere maintenance in response to DNA damage  
    involved_in regulation of DNA repair  
    involved_in regulation of DNA replication  
    involved_in regulation of DNA strand elongation  
    involved_in regulation of cell cycle  
    involved_in regulation of chromosome organization  
    involved_in regulation of embryonic development  
    involved_in regulation of fibroblast apoptotic process PubMed 
    involved_in regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within telomerase RNA localization to Cajal body PubMed 
    involved_in telomere maintenance  
    Items 1 - 20 of 26
    Component Evidence Code Pubs
    part_of Ino80 complex  
    part_of Ino80 complex  
    part_of MLL1 complex  
    part_of MLL1 complex  
    part_of NuA4 histone acetyltransferase complex  
    part_of NuA4 histone acetyltransferase complex  
    part_of NuA4 histone acetyltransferase complex  
    part_of R2TP complex  
    part_of R2TP complex  
    part_of R2TP complex  
    part_of RPAP3/R2TP/prefoldin-like complex  
    part_of Swr1 complex  
    part_of Swr1 complex  
    part_of Swr1 complex  
    located_in centrosome  
    located_in cytosol  
    located_in dynein axonemal particle  
    located_in nuclear matrix PubMed 
    located_in nuclear membrane  
    located_in nucleoplasm  
    part_of nucleosome  
    located_in nucleus  
    located_in nucleus  
    part_of protein folding chaperone complex  
    part_of protein-containing complex PubMed 
    part_of ribonucleoprotein complex  
    Items 1 - 20 of 26

    General protein information

    Preferred Names
    ruvB-like 1
    Names
    49 kDa TATA box-binding protein-interacting protein
    49 kDa TBP-interacting protein
    DNA helicase p50
    RuvB-like protein 1
    pontin 52
    NP_671706.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_147177.1NP_671706.1  ruvB-like 1

      See identical proteins and their annotated locations for NP_671706.1

      Status: PROVISIONAL

      Source sequence(s)
      AB002406
      UniProtKB/Swiss-Prot
      P60123
      UniProtKB/TrEMBL
      A0A8L2Q944, A6IB44
      Related
      ENSRNOP00000075190.1, ENSRNOT00000090875.3
      Conserved Domains (1) summary
      COG1224
      Location:2455
      TIP49; DNA helicase TIP49, TBP-interacting protein [Transcription]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      122489754..122524666
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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