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    Dnah6 dynein, axonemal, heavy chain 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 117250, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dnah6provided by RGD
    Official Full Name
    dynein, axonemal, heavy chain 6provided by RGD
    Primary source
    RGD:621797
    See related
    EnsemblRapid:ENSRNOG00000015581 AllianceGenome:RGD:621797
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    axo a; Dnahc6
    Summary
    Predicted to enable dynein intermediate chain binding activity; dynein light intermediate chain binding activity; and minus-end-directed microtubule motor activity. Predicted to be involved in cilium movement involved in cell motility. Predicted to be located in axoneme and microtubule. Predicted to be part of dynein complex. Predicted to be active in 9+2 motile cilium. Orthologous to human DNAH6 (dynein axonemal heavy chain 6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 64.4), Testes (RPKM 64.4) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dnah6 in Genome Data Viewer
    Location:
    4q32
    Exon count:
    77
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (106622235..106842461, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (105064123..105284361, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (100936834..101157511, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene thymosin, beta 10 Neighboring gene U4 spliceosomal RNA Neighboring gene prohibitin 1, pseudogene 4 Neighboring gene U4 spliceosomal RNA Neighboring gene uncharacterized LOC120102311 Neighboring gene succinate-CoA ligase GDP/ADP-forming subunit alpha

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of seven rat axonemal dynein heavy chain genes: expression during ciliated cell differentiation. Andrews KL, et al. Mol Biol Cell, 1996 Jan. PMID 8741840, Free PMC Article
    2. Metabotropic glutamate receptor 5 knockout promotes motor and biochemical alterations in a mouse model of Huntington's disease. Ribeiro FM, et al. Hum Mol Genet, 2014 Apr 15. PMID 24282028
    3. Identification and molecular evolution of new dynein-like protein sequences in rat brain. Tanaka Y, et al. J Cell Sci, 1995 May. PMID 7657712
    4. Multiple mouse chromosomal loci for dynein-based motility. Vaughan KT, et al. Genomics, 1996 Aug 15. PMID 8812413
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dynein intermediate chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dynein light intermediate chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables minus-end-directed microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cilium movement involved in cell motility IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in 9+2 motile cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in axoneme IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of dynein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    dynein axonemal heavy chain 6
    Names
    axonemal dynein heavy chain
    dynein heavy chain 6, axonemal
    dynein, axonemal, heavy polypeptide 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001419792.1 → NP_001406721.1  dynein axonemal heavy chain 6

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A0A8I6ADI4, F1LXT8
      Related
      ENSRNOP00000110825.1, ENSRNOT00000124975.1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      106622235..106842461 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039108712.2 → XP_038964640.1  dynein axonemal heavy chain 6 isoform X1

      UniProtKB/TrEMBL
      A0A8I6ADI4
      Related
      ENSRNOP00000020894.8, ENSRNOT00000020894.8
      Conserved Domains (4) summary
      COG5245
      Location:1127 → 3774
      DYN1; Dynein, heavy chain [Cytoskeleton]
      pfam08393
      Location:887 → 1307
      DHC_N2; Dynein heavy chain, N-terminal region 2
      pfam12774
      Location:1441 → 1767
      AAA_6; Hydrolytic ATP binding site of dynein motor region D1
      pfam18199
      Location:3827 → 4152
      Dynein_C; Dynein heavy chain C-terminal domain
    Nucleotide Protein Strain
    Heading Accession and Version

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