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    Dnah11 dynein, axonemal, heavy chain 11 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 117253, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dnah11provided by RGD
    Official Full Name
    dynein, axonemal, heavy chain 11provided by RGD
    Primary source
    RGD:621088
    See related
    EnsemblRapid:ENSRNOG00000005451 AllianceGenome:RGD:621088
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Dnahc11
    Summary
    Predicted to enable dynein intermediate chain binding activity; dynein light intermediate chain binding activity; and minus-end-directed microtubule motor activity. Predicted to be involved in cilium movement involved in cell motility and protein localization to motile cilium. Predicted to act upstream of or within several processes, including determination of left/right symmetry; flagellated sperm motility; and regulation of cilium beat frequency. Predicted to be located in 9+0 motile cilium and proximal portion of axoneme. Predicted to be part of dynein complex. Predicted to be active in 9+2 motile cilium and axoneme. Human ortholog(s) of this gene implicated in Kartagener syndrome and primary ciliary dyskinesia 7. Orthologous to human DNAH11 (dynein axonemal heavy chain 11). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 59.0), Testes (RPKM 46.0) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dnah11 in Genome Data Viewer
    Location:
    6q33
    Exon count:
    84
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (144982130..145298523, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (138839175..139155554, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (145784893..146099212, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene cell division cycle associated 7 like Neighboring gene small nucleolar RNA SNORA7 Neighboring gene ribosomal protein L32, pseudogene 3 Neighboring gene uncharacterized LOC120093173 Neighboring gene uncharacterized LOC134479494 Neighboring gene Sp4 transcription factor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mutations of DNAH11 in patients with primary ciliary dyskinesia with normal ciliary ultrastructure. Knowles MR, et al. Thorax, 2012 May. PMID 22184204, Free PMC Article
    2. Static respiratory cilia associated with mutations in Dnahc11/DNAH11: a mouse model of PCD. Lucas JS, et al. Hum Mutat, 2012 Mar. PMID 22102620
    3. Targeted deletion of the ATP binding domain of left-right dynein confirms its role in specifying development of left-right asymmetries. Supp DM, et al. Development, 1999 Dec. PMID 10556073, Free PMC Article
    4. Left-right asymmetry defect in the hippocampal circuitry impairs spatial learning and working memory in iv mice. Goto K, et al. PLoS One, 2010 Nov 17. PMID 21103351, Free PMC Article
    5. Right isomerism of the brain in inversus viscerum mutant mice. Kawakami R, et al. PLoS One, 2008 Apr 16. PMID 18414654, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dynein intermediate chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dynein light intermediate chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables minus-end-directed microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within cardiac septum morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cilium movement ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cilium movement involved in cell motility IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within determination of left/right asymmetry in nervous system ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within determination of left/right symmetry ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within epithelial cilium movement involved in determination of left/right asymmetry ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within epithelial cilium movement involved in extracellular fluid movement ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within flagellated sperm motility ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within heart development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within learning or memory ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to motile cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of cilium beat frequency ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in 9+0 motile cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in 9+2 motile cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in 9+2 motile cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in axoneme IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in axoneme ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of dynein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in motile cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in proximal portion of axoneme ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    dynein heavy chain 11, axonemal; dynein axonemal heavy chain 11
    Names
    dynein, axon, heavy chain 11
    dynein, axonemal, heavy polypeptide 11

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      144982130..145298523 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039078094.2 → XP_038934022.1  dynein axonemal heavy chain 11 isoform X5

      UniProtKB/TrEMBL
      E9PU24
      Related
      ENSRNOP00000007233.8, ENSRNOT00000007233.8
      Conserved Domains (6) summary
      COG5245
      Location:1523 → 4137
      DYN1; Dynein, heavy chain [Cytoskeleton]
      pfam12777
      Location:3068 → 3412
      MT; Microtubule-binding stalk of dynein motor
      pfam08385
      Location:220 → 789
      DHC_N1; Dynein heavy chain, N-terminal region 1
      pfam08393
      Location:1296 → 1695
      DHC_N2; Dynein heavy chain, N-terminal region 2
      pfam12774
      Location:1835 → 2161
      AAA_6; Hydrolytic ATP binding site of dynein motor region D1
      pfam18199
      Location:4190 → 4485
      Dynein_C; Dynein heavy chain C-terminal domain

    2. XM_063262810.1 → XP_063118880.1  dynein axonemal heavy chain 11 isoform X12

    3. XM_039078093.2 → XP_038934021.1  dynein axonemal heavy chain 11 isoform X4

      Conserved Domains (6) summary
      COG5245
      Location:1550 → 4138
      DYN1; Dynein, heavy chain [Cytoskeleton]
      pfam12777
      Location:3069 → 3413
      MT; Microtubule-binding stalk of dynein motor
      pfam08385
      Location:220 → 789
      DHC_N1; Dynein heavy chain, N-terminal region 1
      pfam08393
      Location:1296 → 1722
      DHC_N2; Dynein heavy chain, N-terminal region 2
      pfam12774
      Location:1862 → 2164
      AAA_6; Hydrolytic ATP binding site of dynein motor region D1
      pfam18199
      Location:4191 → 4486
      Dynein_C; Dynein heavy chain C-terminal domain

    4. XM_039078092.2 → XP_038934020.1  dynein axonemal heavy chain 11 isoform X3

      Conserved Domains (6) summary
      COG5245
      Location:1550 → 4164
      DYN1; Dynein, heavy chain [Cytoskeleton]
      pfam12777
      Location:3095 → 3439
      MT; Microtubule-binding stalk of dynein motor
      pfam08385
      Location:220 → 789
      DHC_N1; Dynein heavy chain, N-terminal region 1
      pfam08393
      Location:1296 → 1722
      DHC_N2; Dynein heavy chain, N-terminal region 2
      pfam12774
      Location:1862 → 2188
      AAA_6; Hydrolytic ATP binding site of dynein motor region D1
      pfam18199
      Location:4217 → 4502
      Dynein_C; Dynein heavy chain C-terminal domain

    5. XM_039078091.2 → XP_038934019.1  dynein axonemal heavy chain 11 isoform X2

      UniProtKB/TrEMBL
      A0A8I6GH84
      Related
      ENSRNOP00000111058.1, ENSRNOT00000152917.1
      Conserved Domains (6) summary
      COG5245
      Location:1550 → 4164
      DYN1; Dynein, heavy chain [Cytoskeleton]
      pfam12777
      Location:3095 → 3439
      MT; Microtubule-binding stalk of dynein motor
      pfam08385
      Location:220 → 789
      DHC_N1; Dynein heavy chain, N-terminal region 1
      pfam08393
      Location:1296 → 1722
      DHC_N2; Dynein heavy chain, N-terminal region 2
      pfam12774
      Location:1862 → 2188
      AAA_6; Hydrolytic ATP binding site of dynein motor region D1
      pfam18199
      Location:4217 → 4512
      Dynein_C; Dynein heavy chain C-terminal domain

    6. XM_063262808.1 → XP_063118878.1  dynein axonemal heavy chain 11 isoform X1

    7. XM_039078095.1 → XP_038934023.1  dynein axonemal heavy chain 11 isoform X6

      Conserved Domains (6) summary
      COG5245
      Location:1376 → 3990
      DYN1; Dynein, heavy chain [Cytoskeleton]
      pfam12777
      Location:2921 → 3265
      MT; Microtubule-binding stalk of dynein motor
      pfam08385
      Location:46 → 615
      DHC_N1; Dynein heavy chain, N-terminal region 1
      pfam08393
      Location:1122 → 1548
      DHC_N2; Dynein heavy chain, N-terminal region 2
      pfam12774
      Location:1688 → 2014
      AAA_6; Hydrolytic ATP binding site of dynein motor region D1
      pfam18199
      Location:4043 → 4338
      Dynein_C; Dynein heavy chain C-terminal domain

    8. XM_039078097.2 → XP_038934025.1  dynein axonemal heavy chain 11 isoform X7

      Related
      ENSRNOP00000111123.1, ENSRNOT00000170678.1
      Conserved Domains (6) summary
      COG5245
      Location:1248 → 3862
      DYN1; Dynein, heavy chain [Cytoskeleton]
      pfam12777
      Location:2793 → 3137
      MT; Microtubule-binding stalk of dynein motor
      pfam08385
      Location:7 → 487
      DHC_N1; Dynein heavy chain, N-terminal region 1
      pfam08393
      Location:994 → 1420
      DHC_N2; Dynein heavy chain, N-terminal region 2
      pfam12774
      Location:1560 → 1886
      AAA_6; Hydrolytic ATP binding site of dynein motor region D1
      pfam18199
      Location:3915 → 4210
      Dynein_C; Dynein heavy chain C-terminal domain

    9. XM_063262809.1 → XP_063118879.1  dynein axonemal heavy chain 11 isoform X8

    10. XM_039078099.2 → XP_038934027.1  dynein axonemal heavy chain 11 isoform X9

      Conserved Domains (5) summary
      COG5245
      Location:247 → 2550
      DYN1; Dynein, heavy chain [Cytoskeleton]
      pfam12777
      Location:1481 → 1825
      MT; Microtubule-binding stalk of dynein motor
      pfam08393
      Location:52 → 108
      DHC_N2; Dynein heavy chain, N-terminal region 2
      pfam12774
      Location:248 → 574
      AAA_6; Hydrolytic ATP binding site of dynein motor region D1
      pfam18199
      Location:2603 → 2898
      Dynein_C; Dynein heavy chain C-terminal domain

    11. XM_039078100.1 → XP_038934028.1  dynein axonemal heavy chain 11 isoform X10

      UniProtKB/TrEMBL
      A6KDM4
      Conserved Domains (5) summary
      COG5245
      Location:176 → 2479
      DYN1; Dynein, heavy chain [Cytoskeleton]
      pfam12777
      Location:1410 → 1754
      MT; Microtubule-binding stalk of dynein motor
      pfam08393
      Location:1 → 37
      DHC_N2; Dynein heavy chain, N-terminal region 2
      pfam12774
      Location:177 → 503
      AAA_6; Hydrolytic ATP binding site of dynein motor region D1
      pfam18199
      Location:2532 → 2827
      Dynein_C; Dynein heavy chain C-terminal domain

    12. XM_039078101.2 → XP_038934029.1  dynein axonemal heavy chain 11 isoform X11

      UniProtKB/TrEMBL
      A6KDM4
      Conserved Domains (6) summary
      COG5245
      Location:1 → 2194
      DYN1; Dynein, heavy chain [Cytoskeleton]
      pfam12777
      Location:1125 → 1469
      MT; Microtubule-binding stalk of dynein motor
      pfam12774
      Location:2 → 218
      AAA_6; Hydrolytic ATP binding site of dynein motor region D1
      pfam12780
      Location:853 → 1112
      AAA_8; P-loop containing dynein motor region D4
      pfam12781
      Location:1495 → 1709
      AAA_9; ATP-binding dynein motor region D5
      pfam18199
      Location:2247 → 2542
      Dynein_C; Dynein heavy chain C-terminal domain
    Nucleotide Protein Strain
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