Il1rn interleukin 1 receptor antagonist [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Il1rnprovided by RGD
Official Full Name: interleukin 1 receptor antagonistprovided by RGD
Primary source: RGD:621159
See related: EnsemblRapid:ENSRNOG00000005871 AllianceGenome:RGD:621159
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Il1ra; IL-1ra
Summary: Enables interleukin-1 receptor binding activity. Involved in several processes, including cellular response to norepinephrine stimulus; chronic inflammatory response to antigenic stimulus; and fever generation. Located in extracellular space. Used to study adult respiratory distress syndrome; anti-basement membrane glomerulonephritis; hypertension; silicosis; and transient cerebral ischemia. Biomarker of encephalitis and pneumonia. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); eye disease (multiple); kidney failure (multiple); lung disease (multiple); and vascular disease (multiple). Orthologous to human IL1RN (interleukin 1 receptor antagonist). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Liver (RPKM 37.2), Lung (RPKM 29.2) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3p13

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (27509836..27525738)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (7111567..7127451)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (1449778..1468624)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

G-protein-coupled estrogen receptor activation upregulates interleukin-1 receptor antagonist in the hippocampus after global cerebral ischemia: implications for neuronal self-defense.
Title: G-protein-coupled estrogen receptor activation upregulates interleukin-1 receptor antagonist in the hippocampus after global cerebral ischemia: implications for neuronal self-defense.
IL-1beta is the key trigger of neuroinflammation and that IL-1ra prevents the neuroinflammation entering the chronic state
Title: Brain interleukin-1β and the intrinsic receptor antagonist control peripheral Toll-like receptor 3-mediated suppression of spontaneous activity in rats.
Interleukin-1beta and interleukin-1 receptor antagonist appear in grey matter additionally to white matter during experimental multiple sclerosis
Title: Interleukin-1β and interleukin-1 receptor antagonist appear in grey matter additionally to white matter lesions during experimental multiple sclerosis.
Gene expression of the natural IL-1 receptor antagonist IL-1ra and IL-18 (but not TNFalpha) is increased in the ipsilateral hippocampus during long-term potentiation.
Title: A cytokine network involving brain-borne IL-1β, IL-1ra, IL-18, IL-6, and TNFα operates during long-term potentiation and learning.
the IL-1ra gene could be transferred and expressed in corneal tissue efficiently. This may be a novel technique for gene transfection to the cornea in situ.
Title: An experimental study on in situ transfection of the interleukin-1 receptor antagonist (IL-1ra) gene into the rat cornea.
Energy-sensing factors coactivator peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1alpha) and AMP-activated protein kinase control expression of inflammatory mediators in liver: induction of interleukin 1 receptor antagonist.
Title: Energy-sensing factors coactivator peroxisome proliferator-activated receptor γ coactivator 1-α (PGC-1α) and AMP-activated protein kinase control expression of inflammatory mediators in liver: induction of interleukin 1 receptor antagonist.
IL1Ra has a role in reducing islet endothelial activation and oxidative stress gene expression in the GK diabetic rat
Title: Islet endothelial activation and oxidative stress gene expression is reduced by IL-1Ra treatment in the type 2 diabetic GK rat.
rhIL-1ra may protect renal injury after asphyxia via inhibiting intrarenal inflammatory response.
Title: [Role of interleukin-1 receptor antagonist in protecting kidney from injury induced by asphyxia in neonatal rats].
physical training has an effect on IL-1beta, IL-6 and IL-1ra concentrations in various brain areas of the rat
Title: Effects of physical training on IL-1beta, IL-6 and IL-1ra concentrations in various brain areas of the rat.
Estrogen-induced protection is associated with a decrease in IL-1beta and an increase in IL-1ra expression in the ischemic hippocampus which suggests that modulation of IL-1beta/IL-1ra might be a part of anti-inflammatory effects of estrogen.
Title: Effects of estrogen on temporal expressions of IL-1beta and IL-1ra in rat organotypic hippocampal slices exposed to oxygen-glucose deprivation.

Submit: New GeneRIF Correction See all GeneRIFs (13)

General gene information

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Markers

AU048745 (e-PCR)
- UniSTS:145195

fl05f06.x1 (e-PCR)
- UniSTS:201902

Il1rn (e-PCR), detects polymorphism
- UniSTS:143549

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cytokine activity	IEA Inferred from Electronic Annotation more info
enables interleukin-1 receptor antagonist activity	IBA Inferred from Biological aspect of Ancestor more info
enables interleukin-1 receptor antagonist activity	ISO Inferred from Sequence Orthology more info
enables interleukin-1 receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables interleukin-1 receptor binding	IEA Inferred from Electronic Annotation more info
enables interleukin-1 receptor binding	ISO Inferred from Sequence Orthology more info
enables interleukin-1 type I receptor antagonist activity	IEA Inferred from Electronic Annotation more info
enables interleukin-1 type I receptor antagonist activity	ISO Inferred from Sequence Orthology more info
enables interleukin-1 type II receptor antagonist activity	IEA Inferred from Electronic Annotation more info
enables interleukin-1 type II receptor antagonist activity	ISO Inferred from Sequence Orthology more info
enables interleukin-1, type I receptor binding	IEA Inferred from Electronic Annotation more info
enables interleukin-1, type I receptor binding	ISO Inferred from Sequence Orthology more info
enables interleukin-1, type I receptor binding	TAS Traceable Author Statement more info	PubMed
enables interleukin-1, type II receptor binding	IEA Inferred from Electronic Annotation more info
enables interleukin-1, type II receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in acute-phase response	ISO Inferred from Sequence Orthology more info
involved_in carboxylic acid metabolic process	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to norepinephrine stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in chronic inflammatory response to antigenic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in female pregnancy	IEP Inferred from Expression Pattern more info	PubMed
involved_in fever generation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in immune response	IEA Inferred from Electronic Annotation more info
involved_in inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within insulin secretion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lipid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell migration	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of glutamate secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of heterotypic cell-cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of heterotypic cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-1-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of interleukin-1-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of interleukin-1-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of membrane potential	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of signal transduction	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of JUN kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to activity	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to glucocorticoid	IEA Inferred from Electronic Annotation more info
involved_in response to glucocorticoid	ISO Inferred from Sequence Orthology more info
involved_in response to interleukin-1	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to interleukin-4	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to starvation	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in extracellular region	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in vesicle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: interleukin-1 receptor antagonist protein

Names: IL-1RN; IL1 inhibitor; IRAP

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022194.2 → NP_071530.1 interleukin-1 receptor antagonist protein precursor

See identical proteins and their annotated locations for NP_071530.1

Status: PROVISIONAL

Source sequence(s)

BC070930, CK364274

UniProtKB/Swiss-Prot

P25086

UniProtKB/TrEMBL

A0A8I6A7A6, A6JSY4

Conserved Domains (1) summary

smart00125
Location:34 → 175

IL1; Interleukin-1 homologues