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    Pcbd1 pterin-4 alpha-carbinolamine dehydratase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29700, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pcbd1provided by RGD
    Official Full Name
    pterin-4 alpha-carbinolamine dehydratase 1provided by RGD
    Primary source
    RGD:3263
    See related
    EnsemblRapid:ENSRNOG00000000566 AllianceGenome:RGD:3263
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Pcd; Phs; DCoH; Pcbd; TCF1
    Summary
    This gene encodes a member of the pterin-4-alpha-carbinolamine dehydratase family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. The encoded protein functions as both a dehydratase involved in tetrahydrobiopterin biosynthesis, and as a cofactor for HNF1A-dependent transcription. [provided by RefSeq, Jan 2014]
    Expression
    Biased expression in Liver (RPKM 770.0) and Kidney (RPKM 464.0) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pcbd1 in Genome Data Viewer
    Location:
    20q11
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (29573362..29587181)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (29037545..29044322)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (30689690..30696465)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L39 like 4 Neighboring gene uncharacterized LOC102555785 Neighboring gene sphingosine-1-phosphate lyase 1 Neighboring gene transfer RNA serine (anticodon AGA) 16

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identity of 4a-carbinolamine dehydratase, a component of the phenylalanine hydroxylation system, and DCoH, a transregulator of homeodomain proteins. Citron BA, et al. Proc Natl Acad Sci U S A, 1992 Dec 15. PMID 1465414, Free PMC Article
    2. Characterization of the chicken and rat DCoH gene domains using an improved ligation-mediated PCR method. Bossow S, et al. Biol Chem, 1998 Nov. PMID 9865610
    3. Characterization of the wild-type form of 4a-carbinolamine dehydratase and two naturally occurring mutants associated with hyperphenylalaninemia. Johnen G, et al. Proc Natl Acad Sci U S A, 1995 Dec 19. PMID 8618906, Free PMC Article
    4. Phenylalanine hydroxylase-stimulating protein/pterin-4 alpha-carbinolamine dehydratase from rat and human liver. Purification, characterization, and complete amino acid sequence. Hauer CR, et al. J Biol Chem, 1993 Mar 5. PMID 8444860
    5. Kinetic stability may determine the interaction dynamics of the bifunctional protein DCoH1, the dimerization cofactor of the transcription factor HNF-1α . Rho H, et al. Biochemistry, 2010 Nov 30. PMID 21047120

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Rat Pcbd1 is a moonlighting protein that has dehydratase activity in addition to functioning as a cofactor which regulates HNF1alpha.
      Title: Identity of 4a-carbinolamine dehydratase, a component of the phenylalanine hydroxylation system, and DCoH, a transregulator of homeodomain proteins.
    2. a point mutation at the DCoH1 tetramer interface, Thr 51 Ser, overcomes the dissociation barrier of the homotetramer and increases the interaction with HNF-1alpha.
      Title: Kinetic stability may determine the interaction dynamics of the bifunctional protein DCoH1, the dimerization cofactor of the transcription factor HNF-1α .
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 4-alpha-hydroxytetrahydrobiopterin dehydratase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 4-alpha-hydroxytetrahydrobiopterin dehydratase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 4-alpha-hydroxytetrahydrobiopterin dehydratase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phenylalanine 4-monooxygenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in L-phenylalanine metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in tetrahydrobiopterin biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tyrosine biosynthetic process, by oxidation of phenylalanine IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    pterin-4-alpha-carbinolamine dehydratase
    Names
    4-alpha-hydroxy-tetrahydropterin dehydratase
    6-pyruvoyl-tetrahydropterin synthase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1)
    dimerization cofactor of HNF1
    phenylalanine hydroxylase-stimulating protein
    pterin carbinolamine dehydratase
    pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha
    NP_001007602.1
    XP_006256476.1
    XP_063135155.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007601.2 → NP_001007602.1  pterin-4-alpha-carbinolamine dehydratase

      See identical proteins and their annotated locations for NP_001007602.1

      Status: VALIDATED

      Source sequence(s)
      DV724713, FM060466, FM067129
      UniProtKB/Swiss-Prot
      P61459
      UniProtKB/TrEMBL
      A0A8L2PZL1, A6K3Y5
      Related
      ENSRNOP00000100247.1, ENSRNOT00000130263.1
      Conserved Domains (1) summary
      cd00914
      Location:24 → 99
      PCD_DCoH_subfamily_b; PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      29573362..29587181
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063279085.1 → XP_063135155.1  pterin-4-alpha-carbinolamine dehydratase isoform X1

      UniProtKB/Swiss-Prot
      P61459
      UniProtKB/TrEMBL
      A0A8L2PZL1, A6K3Y5
      Related
      ENSRNOP00000086732.1, ENSRNOT00000107746.3

    2. XM_006256414.2 → XP_006256476.1  pterin-4-alpha-carbinolamine dehydratase isoform X1

      See identical proteins and their annotated locations for XP_006256476.1

      UniProtKB/Swiss-Prot
      P61459
      UniProtKB/TrEMBL
      A0A8L2PZL1, A6K3Y5
      Conserved Domains (1) summary
      cd00914
      Location:24 → 99
      PCD_DCoH_subfamily_b; PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P61459.2 GenPept UniProtKB/Swiss-Prot:P61459

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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