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    Npr1 natriuretic peptide receptor 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24603, updated on 9-Dec-2024

    Summary

    Official Symbol
    Npr1provided by RGD
    Official Full Name
    natriuretic peptide receptor 1provided by RGD
    Primary source
    RGD:3195
    See related
    EnsemblRapid:ENSRNOG00000014684 AllianceGenome:RGD:3195
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Gca; Npra; Anpra; NPR-A
    Summary
    Enables guanylate cyclase activity. Involved in several processes, including cGMP-mediated signaling; positive regulation of cGMP-mediated signaling; and receptor guanylyl cyclase signaling pathway. Predicted to be located in membrane. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Used to study hypertension. Human ortholog(s) of this gene implicated in myocardial infarction. Orthologous to human NPR1 (natriuretic peptide receptor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 223.9), Lung (RPKM 119.9) and 8 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Npr1 in Genome Data Viewer
    Location:
    2q34
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (178231766..178247591, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (175934181..175950118, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (189840403..189857032, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene 40S ribosomal protein S23 pseudogene Neighboring gene oligosaccharyltransferase complex non-catalytic subunit like 1 Neighboring gene uncharacterized LOC120101091 Neighboring gene transfer RNA methionine (anticodon CAU) 1 Neighboring gene interleukin enhancer binding factor 2

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables guanylate cyclase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables guanylate cyclase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables guanylate cyclase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables hormone binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables natriuretic peptide receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables peptide hormone binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables peptide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables phosphorus-oxygen lyase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in blood vessel diameter maintenance IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cGMP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cGMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cGMP biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cGMP-mediated signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell surface receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in dopamine metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in intracellular signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of smooth muscle cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cGMP-mediated signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in receptor guanylyl cyclase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in receptor guanylyl cyclase signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in receptor guanylyl cyclase signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    NOT acts_upstream_of_or_within regulation of blood pressure ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of blood pressure ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of blood pressure ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of receptor complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    atrial natriuretic peptide receptor 1
    Names
    ANP-A
    ANPR-A
    GC-A
    atrial natriuretic peptide A-type receptor
    atrial natriuretic peptide receptor A
    atrial natriuretic peptide receptor type A
    guanylate cyclase A
    natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)
    NP_036745.1
    XP_006232653.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012613.1NP_036745.1  atrial natriuretic peptide receptor 1 precursor

      See identical proteins and their annotated locations for NP_036745.1

      Status: PROVISIONAL

      Source sequence(s)
      J05677
      UniProtKB/Swiss-Prot
      A1A5N8, P18910
      UniProtKB/TrEMBL
      A0A8I5ZSQ4, A6J6M1
      Related
      ENSRNOP00000020307.3, ENSRNOT00000020307.5
      Conserved Domains (7) summary
      cd06385
      Location:32439
      PBP1_NPR_A; Ligand-binding domain of type A natriuretic peptide receptor
      smart00219
      Location:543797
      TyrKc; Tyrosine kinase, catalytic domain
      smart00044
      Location:8361025
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      cd14042
      Location:530803
      PK_GC-A_B; Pseudokinase domain of the membrane Guanylate Cyclase receptors, GC-A and GC-B
      pfam00211
      Location:8631049
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam01094
      Location:50410
      ANF_receptor; Receptor family ligand binding region
      pfam07701
      Location:812857
      HNOBA; Heme NO binding associated

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      178231766..178247591 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006232591.5XP_006232653.1  atrial natriuretic peptide receptor 1 isoform X1

      See identical proteins and their annotated locations for XP_006232653.1

      UniProtKB/Swiss-Prot
      A1A5N8, P18910
      UniProtKB/TrEMBL
      A0A8I5ZSQ4, A6J6M1
      Conserved Domains (7) summary
      cd06385
      Location:32439
      PBP1_NPR_A; Ligand-binding domain of type A natriuretic peptide receptor
      smart00219
      Location:543797
      TyrKc; Tyrosine kinase, catalytic domain
      smart00044
      Location:8361025
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      cd14042
      Location:530803
      PK_GC-A_B; Pseudokinase domain of the membrane Guanylate Cyclase receptors, GC-A and GC-B
      pfam00211
      Location:8631049
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam01094
      Location:50410
      ANF_receptor; Receptor family ligand binding region
      pfam07701
      Location:812857
      HNOBA; Heme NO binding associated

    RNA

    1. XR_005500239.2 RNA Sequence