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    Dusp6 dual specificity phosphatase 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 116663, updated on 4-Jan-2025

    Summary

    Official Symbol
    Dusp6provided by RGD
    Official Full Name
    dual specificity phosphatase 6provided by RGD
    Primary source
    RGD:70978
    See related
    EnsemblRapid:ENSRNOG00000023896 AllianceGenome:RGD:70978
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Mkp3
    Summary
    Enables protein tyrosine/serine/threonine phosphatase activity. Involved in several processes, including negative regulation of ERK1 and ERK2 cascade; response to growth factor; and response to xenobiotic stimulus. Predicted to be located in nucleoplasm. Predicted to be active in cytosol. Biomarker of brain ischemia and pancreatitis. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 19 with or without anosmia. Orthologous to human DUSP6 (dual specificity phosphatase 6). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Lung (RPKM 343.8), Liver (RPKM 221.4) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Dusp6 in Genome Data Viewer
    Location:
    7q13
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (35979502..35983834)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (34092848..34097186)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (41475163..41479393)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479669 Neighboring gene G protein subunit gamma 5, pseudogene 2 Neighboring gene polypeptide N-acetylgalactosaminyltransferase 4 Neighboring gene POC1 centriolar protein B Neighboring gene uncharacterized LOC120093569 Neighboring gene tubulin, alpha 1B, pseudogene 12

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • MGC93276

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables MAP kinase serine/threonine phosphatase activity  
    enables MAP kinase tyrosine phosphatase activity  
    enables MAP kinase tyrosine/serine/threonine phosphatase activity  
    enables MAP kinase tyrosine/serine/threonine phosphatase activity  
    enables RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity  
    enables RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity  
    enables RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity  
    enables RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity  
    enables RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity  
    enables calmodulin-dependent protein phosphatase activity  
    enables histone H2AXS140 phosphatase activity  
    enables histone H2AXY142 phosphatase activity  
    enables myosin phosphatase activity  
    enables non-membrane spanning protein tyrosine phosphatase activity  
    enables phosphoprotein phosphatase activity  
    enables phosphoprotein phosphatase activity  
    enables protein tyrosine phosphatase activity, metal-dependent  
    enables protein tyrosine/serine/threonine phosphatase activity PubMed 
    enables protein tyrosine/threonine phosphatase activity  
    Process Evidence Code Pubs
    involved_in cell differentiation PubMed 
    involved_in chromatin remodeling  
    involved_in negative regulation of ERK1 and ERK2 cascade  
    involved_in negative regulation of ERK1 and ERK2 cascade PubMed 
    involved_in negative regulation of ERK1 and ERK2 cascade  
    involved_in negative regulation of MAPK cascade  
    acts_upstream_of_or_within negative regulation of protein phosphorylation  
    involved_in peptidyl-tyrosine dephosphorylation  
    involved_in positive regulation of apoptotic process  
    involved_in positive regulation of apoptotic process  
    acts_upstream_of_or_within protein dephosphorylation  
    involved_in regulation of heart growth  
    acts_upstream_of_or_within regulation of heart growth  
    involved_in regulation of transcription by RNA polymerase II  
    involved_in response to growth factor PubMed 
    involved_in response to nitrosative stress  
    involved_in response to organic cyclic compound PubMed 
    involved_in response to xenobiotic stimulus PubMed 
    involved_in signal transduction  
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    located_in cytoplasm  
    is_active_in cytosol  
    located_in cytosol  
    located_in nucleoplasm  
    located_in nucleoplasm  

    General protein information

    Preferred Names
    dual specificity protein phosphatase 6
    Names
    MAP kinase phosphatase 3
    MKP-3
    mitogen-activated protein kinase phosphatase 3
    NP_446335.1
    XP_038934180.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053883.3NP_446335.1  dual specificity protein phosphatase 6

      See identical proteins and their annotated locations for NP_446335.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/Swiss-Prot
      Q64346
      UniProtKB/TrEMBL
      A6IG82
      Related
      ENSRNOP00000087245.1, ENSRNOT00000111909.2
      Conserved Domains (2) summary
      cd01446
      Location:17147
      DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...
      cd14566
      Location:207343
      DSP_MKP_classII; dual specificity phosphatase domain of class II mitogen-activated protein kinase phosphatase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      35979502..35983834
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039078252.2XP_038934180.1  dual specificity protein phosphatase 6 isoform X1

      UniProtKB/TrEMBL
      A0A8L2QHD1
      Related
      ENSRNOP00000032969.4, ENSRNOT00000037844.5
      Conserved Domains (2) summary
      cd01446
      Location:17134
      DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...
      cl28904
      Location:134197
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
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