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    Atp5pf ATP synthase peripheral stalk subunit F6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 94271, updated on 27-Dec-2024

    Summary

    Symbol
    Atp5pfprovided by RGD
    Full Name
    ATP synthase peripheral stalk subunit F6provided by RGD
    Primary source
    RGD:621376
    See related
    EnsemblRapid:ENSRNOG00000001551 AllianceGenome:RGD:621376
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Atp5j
    Summary
    Contributes to ATP hydrolysis activity. Involved in several processes, including negative regulation of icosanoid secretion; positive regulation of heart rate; and response to muscle activity. Located in cell surface and extracellular space. Part of proton-transporting ATP synthase complex, coupling factor F(o). Used to study pulmonary hypertension. Biomarker of pulmonary hypertension. Orthologous to human ATP5PF (ATP synthase peripheral stalk subunit F6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 560.0), Muscle (RPKM 333.2) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Atp5pf in Genome Data Viewer
    Location:
    11q11
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (37368045..37375721, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (23881594..23889581, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (24286806..24294419, complement)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA70 Neighboring gene junctional adhesion molecule 2 Neighboring gene GA binding protein transcription factor subunit alpha Neighboring gene uncharacterized LOC134480962 Neighboring gene amyloid beta precursor protein Neighboring gene cysteine and tyrosine rich 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    General protein information

    Preferred Names
    ATP synthase-coupling factor 6, mitochondrial
    Names
    ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F6
    ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F6
    ATPase subunit F6
    coupling factor 6
    NP_446054.1
    XP_008766825.1
    XP_017453574.1
    XP_017453575.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001428996.1NP_001415925.1  ATP synthase-coupling factor 6, mitochondrial

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000011
      UniProtKB/Swiss-Prot
      P21571
      UniProtKB/TrEMBL
      A6JL59
    2. NM_001428997.1NP_001415926.1  ATP synthase-coupling factor 6, mitochondrial

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000011
      UniProtKB/Swiss-Prot
      P21571
      UniProtKB/TrEMBL
      A6JL59
    3. NM_053602.2NP_446054.1  ATP synthase-coupling factor 6, mitochondrial precursor

      See identical proteins and their annotated locations for NP_446054.1

      Status: VALIDATED

      Source sequence(s)
      X54510
      UniProtKB/Swiss-Prot
      P21571
      UniProtKB/TrEMBL
      A6JL59
      Conserved Domains (1) summary
      pfam05511
      Location:196
      ATP-synt_F6; Mitochondrial ATP synthase coupling factor 6

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      37368045..37375721 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017598085.3XP_017453574.1  ATP synthase-coupling factor 6, mitochondrial isoform X2

      Conserved Domains (1) summary
      pfam05511
      Location:196
      ATP-synt_F6; Mitochondrial ATP synthase coupling factor 6
    2. XM_017598086.3XP_017453575.2  ATP synthase-coupling factor 6, mitochondrial isoform X1

      Related
      ENSRNOP00000002116.3, ENSRNOT00000002116.6
    3. XM_008768603.3XP_008766825.1  ATP synthase-coupling factor 6, mitochondrial isoform X2

      Conserved Domains (1) summary
      pfam05511
      Location:196
      ATP-synt_F6; Mitochondrial ATP synthase coupling factor 6
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