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    Nagk N-acetylglucosamine kinase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 297393, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nagkprovided by RGD
    Official Full Name
    N-acetylglucosamine kinaseprovided by RGD
    Primary source
    RGD:1305057
    See related
    EnsemblRapid:ENSRNOG00000013911 AllianceGenome:RGD:1305057
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable N-acetylglucosamine kinase activity; N-acylmannosamine kinase activity; and muramyl dipeptide kinase activity. Predicted to be involved in several processes, including N-acetylglucosamine catabolic process; UDP-N-acetylglucosamine biosynthetic process; and positive regulation of nucleotide-binding activity oligomerization domain containing 2 signaling pathway. Predicted to act upstream of or within N-acetylglucosamine metabolic process. Orthologous to human NAGK (N-acetylglucosamine kinase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 61.7), Adrenal (RPKM 58.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Nagk in Genome Data Viewer
    Location:
    4q34
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (117838761..117846304)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (116281179..116293870)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (115473848..115485027)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486595 Neighboring gene testis expressed 261 Neighboring gene 60S ribosomal protein L27 pseudogene Neighboring gene poly(A) binding protein interacting protein 2B Neighboring gene uncharacterized LOC134486808

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. N-Acetyl-D-Glucosamine Kinase Promotes the Axonal Growth of Developing Neurons. Islam MA, et al. Mol Cells, 2015 Oct. PMID 26467288, Free PMC Article
    2. The non-canonical effect of N-acetyl-D-glucosamine kinase on the formation of neuronal dendrites. Lee H, et al. Mol Cells, 2014 Mar. PMID 24625575, Free PMC Article
    3. Purification and characterization of N-acetylglucosamine kinase from rat liver--comparison with UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase. Hinderlich S, et al. Eur J Biochem, 1998 Feb 15. PMID 9523722
    4. N-acetyl-D-glucosamine kinase interacts with dynein light-chain roadblock type 1 at Golgi outposts in neuronal dendritic branch points. Islam MA, et al. Exp Mol Med, 2015 Aug 14. PMID 26272270, Free PMC Article
    5. N-acetyl-D-glucosamine kinase is a component of nuclear speckles and paraspeckles. Sharif SR, et al. Mol Cells, 2015 May. PMID 25921606, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. this work studied the role played by NAGK in axonal development.
      Title: N-Acetyl-D-Glucosamine Kinase Promotes the Axonal Growth of Developing Neurons.
    2. Data shows associations between NAGK, speckle, paraspeckle and general transcription factor suggesting its regulatory roles in gene expression.
      Title: N-acetyl-D-glucosamine kinase is a component of nuclear speckles and paraspeckles.
    3. The interaction between NAGK and Dynlrb1 frequently occurs at dendritic branch points.
      Title: N-acetyl-D-glucosamine kinase interacts with dynein light-chain roadblock type 1 at Golgi outposts in neuronal dendritic branch points.
    4. Upregulation of dendritic complexity is a non-canonical function of NAGK.
      Title: The non-canonical effect of N-acetyl-D-glucosamine kinase on the formation of neuronal dendrites.
    5. analysis of oligomeric states of UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase by biophysical methods
      Title: Evidence for dynamic interplay of different oligomeric states of UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase by biophysical methods.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC124788

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables N-acetylglucosamine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables N-acetylglucosamine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables N-acetylglucosamine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables N-acetylglucosamine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables N-acylmannosamine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables muramyl dipeptide kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables muramyl dipeptide kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in N-acetylglucosamine catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within N-acetylglucosamine metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in N-acetylneuraminate catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in UDP-N-acetylglucosamine biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in carbohydrate phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in defense response to bacterium ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in defense response to bacterium ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in response to muramyl dipeptide ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to muramyl dipeptide ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    N-acetyl-D-glucosamine kinase
    Names
    N-acetyl-D-mannosamine kinase
    glcNAc kinase
    muramyl dipeptide kinase
    NP_001032857.1
    XP_006236802.1
    XP_038963273.1
    XP_038963274.1
    XP_038963275.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037768.1 → NP_001032857.1  N-acetyl-D-glucosamine kinase

      See identical proteins and their annotated locations for NP_001032857.1

      Status: PROVISIONAL

      Source sequence(s)
      BC107647
      UniProtKB/Swiss-Prot
      P81799, Q32Q91
      UniProtKB/TrEMBL
      A0A8L2ULG6, A6IAP9
      Related
      ENSRNOP00000084218.1, ENSRNOT00000108444.2
      Conserved Domains (1) summary
      cl17037
      Location:1 → 279
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      117838761..117846304
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006236740.5 → XP_006236802.1  N-acetyl-D-glucosamine kinase isoform X1

      UniProtKB/TrEMBL
      A0A8I6AJS1
      Related
      ENSRNOP00000093402.1, ENSRNOT00000118649.2
      Conserved Domains (1) summary
      cl17037
      Location:1 → 177
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

    2. XM_039107346.2 → XP_038963274.1  N-acetyl-D-glucosamine kinase isoform X3

      Conserved Domains (1) summary
      cl17037
      Location:1 → 155
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

    3. XM_039107347.2 → XP_038963275.1  N-acetyl-D-glucosamine kinase isoform X4

      Conserved Domains (1) summary
      cl17037
      Location:1 → 157
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

    4. XM_039107345.2 → XP_038963273.1  N-acetyl-D-glucosamine kinase isoform X2

      Conserved Domains (1) summary
      cl17037
      Location:29 → 193
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P81799.4 GenPept UniProtKB/Swiss-Prot:P81799

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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