Slc46a1 solute carrier family 46 member 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc46a1provided by RGD
Official Full Name: solute carrier family 46 member 1provided by RGD
Primary source: RGD:1309472
See related: EnsemblRapid:ENSRNOG00000010291 AllianceGenome:RGD:1309472
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: rPCFT; RGD1309472
Summary: Predicted to enable folic acid:proton symporter activity; heme transmembrane transporter activity; and methotrexate transmembrane transporter activity. Predicted to be involved in folate import across plasma membrane; heme transport; and proton transmembrane transport. Located in brush border membrane. Biomarker of chronic kidney disease. Human ortholog(s) of this gene implicated in hereditary folate malabsorption. Orthologous to human SLC46A1 (solute carrier family 46 member 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Liver (RPKM 76.2), Brain (RPKM 31.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q25

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (63859551..63865987)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (63361504..63367940)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (65728508..65741708)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Loss of SLC46A1 decreases tumor iron content in hepatocellular carcinoma.
Title: Loss of SLC46A1 decreases tumor iron content in hepatocellular carcinoma.
Physiological stress could increase heme uptake via heme carrier protein 1 (HCP1) in brains through a transcription factor, Kruppel-like factor 4 (KLF4).
Title: Physiological stress-induced corticosterone increases heme uptake via KLF4-HCP1 signaling pathway in hippocampus neurons.
decreased levels of PCFT and RFC expression in rat PPM are due to decreased association of these proteins with lipid rafts (LR) at the PPM
Title: Biochemical and molecular mechanisms of folate transport in rat pancreas; interference with ethanol ingestion.
Data suggest that the malabsorption of folate in the colon associated with alcoholism is due, in part, to down-regulation of folate transporter expression and association with lipid rafts (for both PCFT/Slc46a1 and reduced folate carrier/Slc19a1).
Title: Folate malabsorption is associated with down-regulation of folate transporter expression and function at colon basolateral membrane in rats.
we provide several lines of evidence that indicate PCFT/HCP1 has a role as the molecular entity of the intestinal folate transport system.
Title: Functional characterization of PCFT/HCP1 as the molecular entity of the carrier-mediated intestinal folate transport system in the rat model.
Slc46a1/PCFT plays critical role in intestinal folate absorption.
Title: Rodent intestinal folate transporters (SLC46A1): secondary structure, functional properties, and response to dietary folate restriction.
Downregulation in the expression of the PCFT and the RFC in colon results in reduced levels of these transporters in colon apical membrane lipid rafts as a mechanism of folate malabsorption during chronic alcoholism.
Title: Reduced levels of folate transporters (PCFT and RFC) in membrane lipid rafts result in colonic folate malabsorption in chronic alcoholism.

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General gene information

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Markers

RH132585 (e-PCR)
- UniSTS:215868

RH133220 (e-PCR)
- UniSTS:216503

D11Seg28 (e-PCR), detects polymorphism
- UniSTS:141802

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables folic acid binding	IEA Inferred from Electronic Annotation more info
enables folic acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables folic acid transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables folic acid:proton symporter activity	ISO Inferred from Sequence Orthology more info
NOT enables heme transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables heme transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables heme transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables methotrexate transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables methotrexate transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables proton transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables symporter activity	ISO Inferred from Sequence Orthology more info
enables symporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in folate import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in folate transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in folic acid transport	ISO Inferred from Sequence Orthology more info
involved_in folic acid transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in heme transport	ISO Inferred from Sequence Orthology more info
involved_in heme transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in methotrexate transport	IEA Inferred from Electronic Annotation more info
involved_in proton transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in basolateral plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in brush border membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in endosome	ISO Inferred from Sequence Orthology more info
located_in endosome	ISS Inferred from Sequence or Structural Similarity more info
located_in endosome membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: proton-coupled folate transporter

Names: PCFT/HCP1; heme carrier protein 1; solute carrier family 46 (folate transporter), member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.