Cpxm1 carboxypeptidase X (M14 family), member 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cpxm1provided by RGD
Official Full Name: carboxypeptidase X (M14 family), member 1provided by RGD
Primary source: RGD:1306937
See related: EnsemblRapid:ENSRNOG00000021220 AllianceGenome:RGD:1306937
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable zinc ion binding activity. Predicted to be active in extracellular space. Orthologous to human CPXM1 (carboxypeptidase X, M14 family member 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Uterus (RPKM 105.0), Heart (RPKM 45.9) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q36

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (138041645..138048443, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (117588532..117595330, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (122913886..122920684, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH131322 (e-PCR)
- UniSTS:214605

AA986902 (e-PCR)
- UniSTS:165211

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
NOT enables carboxypeptidase activity	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
NOT acts_upstream_of_or_within proteolysis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: probable carboxypeptidase X1

Names: carboxypeptidase X 1 (M14 family)

NP_001099981.1

EC 3.4.17.10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106511.1 → NP_001099981.1 probable carboxypeptidase X1 precursor

See identical proteins and their annotated locations for NP_001099981.1

Status: PROVISIONAL

Source sequence(s)

CH473949

UniProtKB/TrEMBL

A6HQ86, D3ZW78

Related

ENSRNOP00000028818.5, ENSRNOT00000028818.7

Conserved Domains (4) summary

cd03869
Location:284 → 609

M14_CPX_like; Peptidase M14 carboxypeptidase subfamily N/E-like; Carboxypeptidase X subgroup

cd11308
Location:613 → 689

Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain

smart00231
Location:107 → 263

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain

cd00057
Location:106 → 262

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.