Cntfr ciliary neurotrophic factor receptor [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cntfrprovided by RGD
Official Full Name: ciliary neurotrophic factor receptorprovided by RGD
Primary source: RGD:1303100
See related: EnsemblRapid:ENSRNOG00000047307 AllianceGenome:RGD:1303100
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: CNTFR-alpha
Summary: Enables ciliary neurotrophic factor receptor activity and cytokine binding activity. Predicted to be involved in ciliary neurotrophic factor-mediated signaling pathway; negative regulation of neuron apoptotic process; and positive regulation of cell population proliferation. Predicted to act upstream of or within several processes, including brainstem development; negative regulation of motor neuron apoptotic process; and suckling behavior. Predicted to be located in apical plasma membrane. Predicted to be part of CNTFR-CLCF1 complex and ciliary neurotrophic factor receptor complex. Predicted to be active in external side of plasma membrane. Orthologous to human CNTFR (ciliary neurotrophic factor receptor). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 47.1), Muscle (RPKM 34.1) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q22

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (61619326..61657359, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (56823448..56861049, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (58041114..58078687, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Absence of axonal sprouting following unilateral lesion in 125-day-old rat supraoptic nucleus may be due to age-dependent decrease in protein levels of ciliary neurotrophic factor receptor alpha.
Title: Absence of axonal sprouting following unilateral lesion in 125-day-old rat supraoptic nucleus may be due to age-dependent decrease in protein levels of ciliary neurotrophic factor receptor alpha.
Compared with the EAE group, luteolin-treated EAE group showed upregulation of CNTF expression and significant increase in cAMP and TAC levels, while it showed significant decrease in cleaved caspase 3, NF-kappaB, and MIP-1alpha levels.
Title: The modulatory effects of luteolin on cyclic AMP/Ciliary neurotrophic factor signaling pathway in experimentally induced autoimmune encephalomyelitis.
Activation of CNTF/CNTFRalpha signaling pathway by hRheb(S16H) transduction of dopaminergic neurons
Title: Activation of CNTF/CNTFRα signaling pathway by hRheb(S16H) transduction of dopaminergic neurons in vivo.
the data suggest that endogenous CNTF receptor signaling in type B stem cells inhibits adult neurogenesis, and further suggest that the regulation may occur in a neuron subtype-specific manner.
Title: Ciliary neurotrophic factor receptor regulation of adult forebrain neurogenesis.
The data strongly suggested that intracellular ciliary neurotrophic factor may directly modulate proopiomelanocortin gene expression via the activation of ciliary neurotrophic factor receptors in the cell nucleus.
Title: The anorexigenic cytokine ciliary neurotrophic factor stimulates POMC gene expression via receptors localized in the nucleus of arcuate neurons.
The results of this study showed taht increased CNTF and CNTFR complex in the sprouting, metabolically active supraoptic nucleus are related directly to the sprouting response and not the increase in neurosecretory activity.
Title: Neuronal activity and axonal sprouting differentially regulate CNTF and CNTF receptor complex in the rat supraoptic nucleus.
Co-administration of ciliary neurotrophic factor with its soluble receptor protects against neuronal death and enhances neurite outgrowth.
Title: Co-administration of ciliary neurotrophic factor with its soluble receptor protects against neuronal death and enhances neurite outgrowth.
CNTF-CNTFRalpha activates the JAK/STAT pathway leading to enhanced Cx43 expression and intercellular coupling
Title: The complex of ciliary neurotrophic factor-ciliary neurotrophic factor receptor alpha up-regulates connexin43 and intercellular coupling in astrocytes via the Janus tyrosine kinase/signal transducer and activator of transcription pathway.
CNTF receptor-alpha is transiently expressed in the cerebral cortex surrounding the hematoma following induction of intracerebral hemorrhage, with a peak at 5 days.
Title: Expression of ciliary neurotrophic factor (CNTF), CNTF receptor alpha (CNTFR-alpha) following experimental intracerebral hemorrhage in rats.
Results show that ciliary neurotrophic factor (CNTF) and its receptor (CNTFRalpha) are differentially regulated in hippocampal neurons and reactive astrocytes following kainic acid injection.
Title: Differential regulation of ciliary neurotrophic factor and its receptor in the rat hippocampus in response to kainic acid-induced excitotoxicity.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

UniSTS:496823 (e-PCR)
- UniSTS:496823

Cntfr (e-PCR), detects polymorphism
- UniSTS:496823

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
contributes_to ciliary neurotrophic factor receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables ciliary neurotrophic factor receptor activity	IEA Inferred from Electronic Annotation more info
enables ciliary neurotrophic factor receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
contributes_to ciliary neurotrophic factor receptor activity	ISO Inferred from Sequence Orthology more info
enables ciliary neurotrophic factor receptor activity	ISO Inferred from Sequence Orthology more info
enables cytokine binding	IEA Inferred from Electronic Annotation more info
enables cytokine binding	IPI Inferred from Physical Interaction more info	PubMed
enables cytokine binding	ISO Inferred from Sequence Orthology more info
enables cytokine receptor activity	IEA Inferred from Electronic Annotation more info
enables interleukin-11 binding	IBA Inferred from Biological aspect of Ancestor more info
enables interleukin-11 receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor binding	IEA Inferred from Electronic Annotation more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in brainstem development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within brainstem development	ISO Inferred from Sequence Orthology more info
involved_in ciliary neurotrophic factor-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in ciliary neurotrophic factor-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within ciliary neurotrophic factor-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in ciliary neurotrophic factor-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cytokine-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in motor neuron apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of motor neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of motor neuron apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of motor neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in sex differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within sex differentiation	ISO Inferred from Sequence Orthology more info
involved_in skeletal muscle organ development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within skeletal muscle organ development	ISO Inferred from Sequence Orthology more info
involved_in suckling behavior	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within suckling behavior	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of CNTFR-CLCF1 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of CNTFR-CLCF1 complex	IEA Inferred from Electronic Annotation more info
part_of CNTFR-CLCF1 complex	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
part_of ciliary neurotrophic factor receptor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of ciliary neurotrophic factor receptor complex	IEA Inferred from Electronic Annotation more info
part_of ciliary neurotrophic factor receptor complex	ISO Inferred from Sequence Orthology more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in side of membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ciliary neurotrophic factor receptor subunit alpha

Names: CNTF receptor subunit alpha; CNTFR alpha; ciliary neurotrophic factor receptor alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001003929.2 → NP_001003929.2 ciliary neurotrophic factor receptor subunit alpha precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

Q08406

UniProtKB/TrEMBL

A0A8I5Y668, A6IIW4

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

61619326..61657359 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063287618.1 → XP_063143688.1 ciliary neurotrophic factor receptor subunit alpha isoform X2

UniProtKB/Swiss-Prot

Q08406

UniProtKB/TrEMBL

A0A8I5Y668, A6IIW4
XM_017593358.3 → XP_017448847.1 ciliary neurotrophic factor receptor subunit alpha isoform X2

UniProtKB/Swiss-Prot

Q08406

UniProtKB/TrEMBL

A0A8I5Y668, A6IIW4

Conserved Domains (3) summary

smart00408
Location:39 → 96

IGc2; Immunoglobulin C-2 Type

smart00410
Location:31 → 105

IG_like; Immunoglobulin like

cd00063
Location:204 → 300

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
XM_063287617.1 → XP_063143687.1 ciliary neurotrophic factor receptor subunit alpha isoform X2

UniProtKB/Swiss-Prot

Q08406

UniProtKB/TrEMBL

A0A8I5Y668, A6IIW4

Related

ENSRNOP00000066185.2, ENSRNOT00000075777.4
XM_039109845.2 → XP_038965773.1 ciliary neurotrophic factor receptor subunit alpha isoform X1

UniProtKB/Swiss-Prot

Q08406

Related

ENSRNOP00000077340.2, ENSRNOT00000120096.2

Conserved Domains (3) summary

smart00408
Location:62 → 119

IGc2; Immunoglobulin C-2 Type

cd00063
Location:227 → 323

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00096
Location:62 → 70

Ig; Ig strand B [structural motif]