Dnaja4 DnaJ heat shock protein family (Hsp40) member A4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dnaja4provided by RGD
Official Full Name: DnaJ heat shock protein family (Hsp40) member A4provided by RGD
Primary source: RGD:1310035
See related: EnsemblRapid:ENSRNOG00000012106 AllianceGenome:RGD:1310035
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable protein-folding chaperone binding activity and unfolded protein binding activity. Predicted to be involved in several processes, including negative regulation of endothelial cell migration; negative regulation of inclusion body assembly; and protein refolding. Predicted to be located in membrane. Predicted to be active in cytosol. Orthologous to human DNAJA4 (DnaJ heat shock protein family (Hsp40) member A4). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 692.5), Muscle (RPKM 548.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q24

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (63975177..63998836)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (55085246..55102715)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (59278262..59294003)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

BF396771 (e-PCR)
- UniSTS:245862

AA799570 (e-PCR)
- UniSTS:260560

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables Hsp70 protein binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein-folding chaperone binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein-folding chaperone binding	ISO Inferred from Sequence Orthology more info
enables unfolded protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in negative regulation of endothelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of inclusion body assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in protein refolding	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein refolding	ISO Inferred from Sequence Orthology more info
involved_in response to heat	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: dnaJ homolog subfamily A member 4

Names: DnaJ (Hsp40) homolog, subfamily A, member 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001025411.2 → NP_001020582.1 dnaJ homolog subfamily A member 4

See identical proteins and their annotated locations for NP_001020582.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/TrEMBL

Q4QR73

Related

ENSRNOP00000101156.1, ENSRNOT00000167883.1

Conserved Domains (4) summary

cd10719
Location:293 → 359

DnaJ_zf; Zinc finger domain of DnaJ and HSP40

cd10747
Location:264 → 490

DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40

PTZ00037
Location:144 → 552

PTZ00037; DnaJ_C chaperone protein; Provisional

pfam00226
Location:165 → 223

DnaJ; DnaJ domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

63975177..63998836

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039081075.2 → XP_038937003.1 dnaJ homolog subfamily A member 4 isoform X1

Conserved Domains (2) summary

PHA03247
Location:8 → 126

PHA03247; large tegument protein UL36; Provisional

PTZ00037
Location:144 → 451

PTZ00037; DnaJ_C chaperone protein; Provisional
XM_063265117.1 → XP_063121187.1 dnaJ homolog subfamily A member 4 isoform X2