Gtpbp1 GTP binding protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gtpbp1provided by RGD
Official Full Name: GTP binding protein 1provided by RGD
Primary source: RGD:1306758
See related: EnsemblRapid:ENSRNOG00000014634 AllianceGenome:RGD:1306758
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables GTPase activity. Involved in GTP metabolic process and positive regulation of mRNA catabolic process. Located in cytosol. Part of cytoplasmic exosome (RNase complex). Orthologous to human GTPBP1 (GTP binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 116.7), Kidney (RPKM 101.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q34

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (113128645..113153094)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (111248254..111272705)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (120923274..120947723)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH138634 (e-PCR)
- UniSTS:220721

RH138439 (e-PCR)
- UniSTS:220526

AI178641 (e-PCR)
- UniSTS:250530

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IDA Inferred from Direct Assay more info	PubMed
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables GTPase activity	ISO Inferred from Sequence Orthology more info
enables alpha-aminoacyl-tRNA binding	ISO Inferred from Sequence Orthology more info
enables tRNA binding	ISO Inferred from Sequence Orthology more info
enables translation elongation factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables translation elongation factor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in GTP metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in cytoplasmic translation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mRNA catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in translational elongation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of cytoplasmic exosome (RNase complex)	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: GTP-binding protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001199315.1 → NP_001186244.1 GTP-binding protein 1

See identical proteins and their annotated locations for NP_001186244.1

Status: PROVISIONAL

Source sequence(s)

CH473950

UniProtKB/Swiss-Prot

D2XV59

UniProtKB/TrEMBL

A0A8I6APY7

Related

ENSRNOP00000039165.4, ENSRNOT00000049247.6

Conserved Domains (4) summary

cd04165
Location:162 → 386

GTPBP1_like; GTP binding protein 1 (GTPBP1)-like family includes GTPBP2

COG5258
Location:48 → 574

GTPBP1; GTPase [General function prediction only]

cd03694
Location:395 → 481

GTPBP_II; Domain II of the GTPBP family of GTP binding proteins

cd03708
Location:487 → 573

GTPBP_III; Domain III of the GP-1 family of GTPases

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

113128645..113153094

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001130496.1: Suppressed sequence

Description

NM_001130496.1: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from human: GTPBP1 (GeneID:9567).