Ighe immunoglobulin heavy constant epsilon [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Igheprovided by RGD
Official Full Name: immunoglobulin heavy constant epsilonprovided by RGD
Primary source: RGD:2880
See related: AllianceGenome:RGD:2880
Gene type: other
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: IGH2
Summary: Predicted to enable MHC class II protein complex binding activity; immunoglobulin receptor binding activity; and peptide antigen binding activity. Predicted to be involved in several processes, including B cell activation; B cell mediated immunity; and leukocyte degranulation. Predicted to be located in extracellular space and plasma membrane. Predicted to be part of IgE B cell receptor complex and MHC class II protein complex. Predicted to be active in late endosome membrane and lysosomal membrane. Orthologous to human IGHE (immunoglobulin heavy constant epsilon). [provided by Alliance of Genome Resources, Dec 2024]
Annotation information: not in current annotation release
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Genomic context

Location:: 6q32

Annotation release	Status	Assembly	Chr	Location
106	latest, but not current	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (138066728..138068606, complement)
106	latest, but not current	Rn_Celera (GCF_000002265.2)	6	AC_000074.1 (129872683..129874561, complement)

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

d6arb2 (e-PCR)
- UniSTS:122178

d6arb3 (e-PCR)
- UniSTS:122180

D6Wox12 (e-PCR)
- UniSTS:118095

D6Wox11 (e-PCR)
- UniSTS:117998

Igh-7 (e-PCR), detects polymorphism
- UniSTS:117998

Other Names

Ig epsilon chain C region
immunoglobulin heavy chain (epsilon polypeptide)

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables MHC class II protein complex binding	IBA Inferred from Biological aspect of Ancestor more info
enables immunoglobulin receptor binding	ISO Inferred from Sequence Orthology more info
enables peptide antigen binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in B cell antigen processing and presentation	ISO Inferred from Sequence Orthology more info
involved_in B cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in B cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in B cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in Fc receptor-mediated immune complex endocytosis	ISO Inferred from Sequence Orthology more info
involved_in adaptive immune memory response	ISO Inferred from Sequence Orthology more info
involved_in antibody-dependent cellular cytotoxicity	ISO Inferred from Sequence Orthology more info
involved_in antigen processing and presentation of exogenous peptide antigen via MHC class II	IBA Inferred from Biological aspect of Ancestor more info
involved_in eosinophil degranulation	ISO Inferred from Sequence Orthology more info
involved_in macrophage activation	ISO Inferred from Sequence Orthology more info
involved_in macrophage differentiation	ISO Inferred from Sequence Orthology more info
involved_in mast cell degranulation	ISO Inferred from Sequence Orthology more info
involved_in peptide antigen assembly with MHC class II protein complex	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of T cell activation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in primary adaptive immune response	ISO Inferred from Sequence Orthology more info
involved_in type 2 immune response	ISO Inferred from Sequence Orthology more info
involved_in type I hypersensitivity	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of IgE B cell receptor complex	ISO Inferred from Sequence Orthology more info
part_of MHC class II protein complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
is_active_in late endosome membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in lysosomal membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info