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    Anks4b ankyrin repeat and sterile alpha motif domain containing 4B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 687561, updated on 9-Dec-2024

    Summary

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    Symbol
    Anks4bprovided by RGD
    Full Name
    ankyrin repeat and sterile alpha motif domain containing 4Bprovided by RGD
    Primary source
    RGD:1584204
    See related
    EnsemblRapid:ENSRNOG00000046181 AllianceGenome:RGD:1584204
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in brush border assembly; protein localization to microvillus; and protein-containing complex assembly. Predicted to act upstream of or within response to endoplasmic reticulum stress. Predicted to be located in several cellular components, including brush border; endoplasmic reticulum membrane; and microvillus. Orthologous to human ANKS4B (ankyrin repeat and sterile alpha motif domain containing 4B). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See Anks4b in Genome Data Viewer
    Location:
    1q36
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (183934528..183989127)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (174534195..174557798)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (189940305..189942113)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene dynein, axonemal, heavy chain 3 Neighboring gene replication protein A3, pseudogene 1 Neighboring gene lipid droplet assembly factor 1 Neighboring gene zona pellucida glycoprotein 2 Neighboring gene crystallin, mu Neighboring gene ATP-binding cassette, subfamily A (ABC1), member 14

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. ANKS4B Is Essential for Intermicrovillar Adhesion Complex Formation. Crawley SW, et al. Dev Cell, 2016 Jan 25. PMID 26812018, Free PMC Article
    2. Harp (harmonin-interacting, ankyrin repeat-containing protein), a novel protein that interacts with harmonin in epithelial tissues. Johnston AM, et al. Genes Cells, 2004 Oct. PMID 15461667
    3. Anks4b, a novel target of HNF4α protein, interacts with GRP78 protein and regulates endoplasmic reticulum stress-induced apoptosis in pancreatic β-cells. Sato Y, et al. J Biol Chem, 2012 Jun 29. PMID 22589549, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC188020

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in brush border assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in brush border assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to microvillus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within response to endoplasmic reticulum stress ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in brush border ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microvillus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ankyrin repeat and SAM domain-containing protein 4B
    Names
    harmonin-interacting ankyrin repeat-containing

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001127650.1 → NP_001121122.1  ankyrin repeat and SAM domain-containing protein 4B

      See identical proteins and their annotated locations for NP_001121122.1

      Status: PROVISIONAL

      Source sequence(s)
      BC166493
      UniProtKB/TrEMBL
      A0A9K3Y7E7, B2GV19, M0RBX2
      Related
      ENSRNOP00000067072.3, ENSRNOT00000075035.4
      Conserved Domains (5) summary
      cd09587
      Location:343 → 409
      SAM_HARP; SAM domain of HARP subfamily
      sd00045
      Location:3 → 29
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:1 → 49
      Ank_4; Ankyrin repeats (many copies)
      pfam12796
      Location:38 → 121
      Ank_2; Ankyrin repeats (3 copies)
      cd21802
      Location:254 → 282
      CEN_ANKS4B; central domain found in ankyrin repeat and SAM domain-containing protein 4B

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      183934528..183989127
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039091027.2 → XP_038946955.1  ankyrin repeat and SAM domain-containing protein 4B isoform X1

      UniProtKB/TrEMBL
      A0A9K3Y7E7, B2GV19, M0RBX2
      Conserved Domains (5) summary
      cd09587
      Location:343 → 409
      SAM_HARP; SAM domain of HARP subfamily
      sd00045
      Location:3 → 29
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:1 → 49
      Ank_4; Ankyrin repeats (many copies)
      pfam12796
      Location:38 → 121
      Ank_2; Ankyrin repeats (3 copies)
      cd21802
      Location:254 → 282
      CEN_ANKS4B; central domain found in ankyrin repeat and SAM domain-containing protein 4B

    2. XM_063274218.1 → XP_063130288.1  ankyrin repeat and SAM domain-containing protein 4B isoform X1

      UniProtKB/TrEMBL
      A0A9K3Y7E7, B2GV19, M0RBX2

    3. XM_063274221.1 → XP_063130291.1  ankyrin repeat and SAM domain-containing protein 4B isoform X1

      UniProtKB/TrEMBL
      A0A9K3Y7E7, B2GV19, M0RBX2

    4. XM_063274220.1 → XP_063130290.1  ankyrin repeat and SAM domain-containing protein 4B isoform X1

      UniProtKB/TrEMBL
      A0A9K3Y7E7, B2GV19, M0RBX2
    Nucleotide Protein Strain
    Heading Accession and Version

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