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    Jam3 junctional adhesion molecule 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 315509, updated on 9-Dec-2024

    Summary

    Official Symbol
    Jam3provided by RGD
    Official Full Name
    junctional adhesion molecule 3provided by RGD
    Primary source
    RGD:1303248
    See related
    EnsemblRapid:ENSRNOG00000009149 AllianceGenome:RGD:1303248
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable cell-cell adhesion mediator activity; identical protein binding activity; and integrin binding activity. Involved in axon regeneration. Predicted to be located in several cellular components, including Schmidt-Lanterman incisure; bicellular tight junction; and paranodal junction. Predicted to be part of filamentous actin and protein complex involved in cell adhesion. Predicted to be active in cell-cell contact zone and plasma membrane. Biomarker of sciatic neuropathy. Orthologous to human JAM3 (junctional adhesion molecule 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 114.4), Brain (RPKM 78.8) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Jam3 in Genome Data Viewer
    Location:
    8q13
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (33767606..33828451, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (25508461..25569306, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (28147110..28208466, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene VPS26 retromer complex component B Neighboring gene non-SMC condensin II complex, subunit D3 Neighboring gene uncharacterized LOC134480003 Neighboring gene uncharacterized LOC134480004 Neighboring gene small nucleolar RNA SNORD113/SNORD114 family

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • MGC94974

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cell-cell adhesion mediator activity  
    enables cell-cell adhesion mediator activity  
    enables cell-cell adhesion mediator activity  
    enables identical protein binding  
    enables integrin binding  
    enables integrin binding  
    enables integrin binding  
    enables protein heterodimerization activity  
    enables protein homodimerization activity  
    Items 1 - 25 of 44
    Process Evidence Code Pubs
    acts_upstream_of_or_within adaptive immune response  
    involved_in adherens junction assembly  
    involved_in adherens junction assembly  
    involved_in angiogenesis  
    involved_in angiogenesis  
    involved_in apical protein localization  
    involved_in apical protein localization  
    involved_in axon regeneration PubMed 
    involved_in cell adhesion  
    acts_upstream_of_or_within cell adhesion  
    involved_in cell migration  
    acts_upstream_of_or_within cell migration  
    involved_in cell-cell adhesion  
    involved_in cell-cell adhesion  
    acts_upstream_of_or_within cell-matrix adhesion  
    acts_upstream_of_or_within establishment of cell polarity  
    involved_in granulocyte migration  
    involved_in granulocyte migration  
    involved_in hematopoietic stem cell migration to bone marrow  
    involved_in hematopoietic stem cell migration to bone marrow  
    involved_in heterotypic cell-cell adhesion  
    involved_in heterotypic cell-cell adhesion  
    acts_upstream_of_or_within leukocyte migration involved in inflammatory response  
    acts_upstream_of_or_within myelination  
    acts_upstream_of_or_within myeloid progenitor cell differentiation  
    involved_in negative regulation of cell adhesion mediated by integrin  
    involved_in negative regulation of cell adhesion mediated by integrin  
    involved_in negative regulation of integrin activation  
    involved_in negative regulation of integrin activation  
    acts_upstream_of_or_within neutrophil homeostasis  
    involved_in positive regulation of membrane permeability  
    acts_upstream_of_or_within positive regulation of membrane permeability  
    involved_in positive regulation of monocyte extravasation  
    acts_upstream_of_or_within positive regulation of monocyte extravasation  
    involved_in protein localization to cell junction  
    involved_in protein localization to cell junction  
    involved_in protein localization to cell surface  
    involved_in protein localization to cell surface  
    acts_upstream_of_or_within regulation of actin cytoskeleton organization by cell-cell adhesion  
    involved_in regulation of neutrophil chemotaxis  
    involved_in regulation of neutrophil chemotaxis  
    acts_upstream_of_or_within spermatid development  
    acts_upstream_of_or_within spermatogenesis  
    acts_upstream_of_or_within transmission of nerve impulse  
    Items 1 - 25 of 44
    Items 1 - 20 of 29
    Component Evidence Code Pubs
    located_in Golgi apparatus  
    located_in Golgi apparatus  
    located_in Schmidt-Lanterman incisure  
    located_in bicellular tight junction  
    located_in bicellular tight junction  
    located_in bicellular tight junction  
    is_active_in cell-cell contact zone  
    located_in cell-cell contact zone  
    located_in cell-cell contact zone  
    located_in cell-cell junction  
    located_in desmosome  
    located_in desmosome  
    located_in extracellular space  
    located_in extracellular space  
    part_of filamentous actin  
    part_of filamentous actin  
    located_in membrane  
    located_in microvillus  
    located_in microvillus  
    located_in paranodal junction  
    is_active_in plasma membrane  
    located_in plasma membrane  
    located_in plasma membrane  
    located_in plasma membrane  
    part_of protein complex involved in cell adhesion  
    part_of protein complex involved in cell adhesion  
    part_of protein complex involved in cell adhesion  
    part_of protein complex involved in cell adhesion  
    located_in tight junction  
    Items 1 - 20 of 29

    General protein information

    Preferred Names
    junctional adhesion molecule C
    Names
    JAM-3
    JAM-C

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004269.1NP_001004269.1  junctional adhesion molecule C precursor

      See identical proteins and their annotated locations for NP_001004269.1

      Status: PROVISIONAL

      Source sequence(s)
      BC079429
      UniProtKB/Swiss-Prot
      Q68FQ2
      UniProtKB/TrEMBL
      A0A8I6ANI6, A6JYE0
      Related
      ENSRNOP00000012247.4, ENSRNOT00000012247.6
      Conserved Domains (3) summary
      cd00096
      Location:156231
      Ig; Immunoglobulin domain
      pfam07679
      Location:39135
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:37118
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      33767606..33828451 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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