Utp25 UTP25 small subunit processome component [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Utp25provided by RGD
Official Full Name: UTP25 small subunit processome componentprovided by RGD
Primary source: RGD:1359148
See related: EnsemblRapid:ENSRNOG00000004789 AllianceGenome:RGD:1359148
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Def; Diexf
Summary: Predicted to enable U3 snoRNA binding activity and rRNA binding activity. Predicted to be involved in several processes, including maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); protein destabilization; and protein localization to nucleolus. Predicted to be part of small-subunit processome. Predicted to be active in nucleolus. Orthologous to human UTP25 (UTP25 small subunit processome component). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 68.6), Spleen (RPKM 64.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 13q27

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (107159092..107180361, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (104630390..104651681, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (111828052..111849654, complement)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables U3 snoRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables rRNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in embryonic organ development	ISO Inferred from Sequence Orthology more info
involved_in embryonic organ development	ISS Inferred from Sequence or Structural Similarity more info
involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of embryonic development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of embryonic development	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein destabilization	ISO Inferred from Sequence Orthology more info
involved_in protein destabilization	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein localization to nucleolus	ISO Inferred from Sequence Orthology more info
involved_in protein localization to nucleolus	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISS Inferred from Sequence or Structural Similarity more info
part_of small-subunit processome	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: U3 small nucleolar RNA-associated protein 25 homolog

Names: UTP25, small subunit processor component; novel putative protein similar to YIL091C yeast hypothetical 84 kD protein from SGA1-KTR7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001013986.2 → NP_001014008.1 U3 small nucleolar RNA-associated protein 25 homolog

See identical proteins and their annotated locations for NP_001014008.1

Status: VALIDATED

Source sequence(s)

BC087114, CB569988

UniProtKB/Swiss-Prot

Q5M9G7

UniProtKB/TrEMBL

A6JH19

Related

ENSRNOP00000006395.4, ENSRNOT00000006395.8

Conserved Domains (1) summary

pfam06862
Location:283 → 758

UTP25; Utp25, U3 small nucleolar RNA-associated SSU processome protein 25