Tlr8 toll-like receptor 8 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tlr8provided by RGD
Official Full Name: toll-like receptor 8provided by RGD
Primary source: RGD:1590327
See related: EnsemblRapid:ENSRNOG00000045992 AllianceGenome:RGD:1590327
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable identical protein binding activity; nucleic acid binding activity; and pattern recognition receptor activity. Predicted to be involved in several processes, including cellular response to mechanical stimulus; pattern recognition receptor signaling pathway; and regulation of cytokine production. Predicted to act upstream of or within regulation of protein phosphorylation. Predicted to be located in external side of plasma membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human TLR8 (toll like receptor 8). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 165.1), Lung (RPKM 67.6) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: Xq13

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (30708714..30733104)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (27091780..27116092)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (28539158..28562803)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Long non-coding RNA TLR8-AS1 induces preeclampsia through increasing TLR8/STAT1 axis.
Title: Long non-coding RNA TLR8-AS1 induces preeclampsia through increasing TLR8/STAT1 axis.
MicroRNA-18a-5p mitigates oxygen-glucose-deprivation/reoxygenation-induced injury through suppression of TLRs/NF-kappaB signaling by targeting TLR8 in PC12 cells.
Title: MicroRNA-18a-5p mitigates oxygen-glucose-deprivation/reoxygenation-induced injury through suppression of TLRs/NF-κB signaling by targeting TLR8 in PC12 cells.
aortic angiogenesis is preceded by an immune reaction with overexpression of Toll-like receptors (TLRs) and TLR-inducible genes.
Title: Regulation of angiogenesis, mural cell recruitment and adventitial macrophage behavior by Toll-like receptors.
toll-like receptors and nucleotide-binding oligomerization domain 2 combinations are contributors to the signaling cascades resulting in purinergic microglial activation
Title: Combinations of TLR and NOD2 ligands stimulate rat microglial P2X4R expression.
A five-amino-acid motif in the undefined region of the TLR8 ectodomain is required for species-specific ligand recognition.
Title: A five-amino-acid motif in the undefined region of the TLR8 ectodomain is required for species-specific ligand recognition.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables double-stranded RNA binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables pattern recognition receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables single-stranded RNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in canonical NF-kappaB signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to mechanical stimulus	ISO Inferred from Sequence Orthology more info
involved_in defense response to virus	IBA Inferred from Biological aspect of Ancestor more info
involved_in defense response to virus	ISO Inferred from Sequence Orthology more info
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of interleukin-12 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of innate immune response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interferon-alpha production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interferon-beta production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-1 beta production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-6 production	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of interleukin-6 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-8 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of type II interferon production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in response to virus	ISO Inferred from Sequence Orthology more info
involved_in toll-like receptor 8 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in toll-like receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: toll-like receptor 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001101009.1 → NP_001094479.1 toll-like receptor 8 precursor

See identical proteins and their annotated locations for NP_001094479.1

Status: PROVISIONAL

Source sequence(s)

EF032638

UniProtKB/TrEMBL

A0A8K2AD52, A5H300

Related

ENSRNOP00000066040.1, ENSRNOT00000073535.3

Conserved Domains (5) summary

PRK15370
Location:21 → 218

PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP

TIGR00864
Location:730 → 813

PCC; polycystin cation channel protein

smart00255
Location:868 → 1004

TIR; Toll - interleukin 1 - resistance

PLN00113
Location:141 → 664

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

sd00033
Location:62 → 85

LRR_RI; leucine-rich repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086039.1 Reference GRCr8

Range

30708714..30733104

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039100074.2 → XP_038956002.1 toll-like receptor 8 isoform X1

UniProtKB/TrEMBL

A0A8K2AD52, A5H300

Related

ENSRNOP00000109523.1, ENSRNOT00000158384.1

Conserved Domains (5) summary

PRK15370
Location:21 → 218

PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP

TIGR00864
Location:730 → 813

PCC; polycystin cation channel protein

smart00255
Location:868 → 1004

TIR; Toll - interleukin 1 - resistance

PLN00113
Location:141 → 664

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

sd00033
Location:62 → 85

LRR_RI; leucine-rich repeat [structural motif]