U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Marf1 meiosis regulator and mRNA stability factor 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 170946, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Symbol
    Marf1provided by RGD
    Full Name
    meiosis regulator and mRNA stability factor 1provided by RGD
    Primary source
    RGD:619770
    See related
    EnsemblRapid:ENSRNOG00000056248 AllianceGenome:RGD:619770
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Lkap
    Summary
    Predicted to enable CCR4-NOT complex binding activity. Predicted to be involved in female meiotic nuclear division; oogenesis; and regulation of gene expression. Predicted to act upstream of or within double-strand break repair. Predicted to be located in Golgi apparatus and peroxisome. Predicted to be active in cytoplasm. Orthologous to human MARF1 (meiosis regulator and mRNA stability factor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 255.8), Spleen (RPKM 208.9) and 9 other tissues See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Marf1 in Genome Data Viewer
    Location:
    10q11
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (1395271..1439974)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (888053..932760)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (908806..953481)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene nudE neurodevelopment protein 1 Neighboring gene microRNA 484 Neighboring gene excision repair cross-complementing rodent repair deficiency, complementation group 4-like 1 Neighboring gene myocardin related transcription factor B

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Limkain b1, a novel human autoantigen localized to a subset of ABCD3 and PXF marked peroxisomes. Dunster K, et al. Clin Exp Immunol, 2005 Jun. PMID 15932519, Free PMC Article
    2. Meiosis arrest female 1 (MARF1) has nuage-like function in mammalian oocytes. Su YQ, et al. Proc Natl Acad Sci U S A, 2012 Nov 13. PMID 23090997, Free PMC Article
    3. MARF1 regulates essential oogenic processes in mice. Su YQ, et al. Science, 2012 Mar 23. PMID 22442484, Free PMC Article
    4. Docking motif-guided mapping of the interactome of protein phosphatase-1. Hendrickx A, et al. Chem Biol, 2009 Apr 24. PMID 19389623
    5. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables CCR4-NOT complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA nuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within double-strand break repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in female meiotic nuclear division ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in female meiotic nuclear division ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in oogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in oogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in oogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of gene expression ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in peroxisome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in peroxisome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    meiosis regulator and mRNA stability factor 1
    Names
    limkain-b1
    meiosis arrest female 1
    meiosis arrest female protein 1
    meiosis arrest female protein 1-like

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133421.3 → NP_596912.2  meiosis regulator and mRNA stability factor 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      F1LNE9, Q8VIG2
      UniProtKB/TrEMBL
      A6KU39
      Related
      ENSRNOP00000073018.1, ENSRNOT00000091520.3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      1395271..1439974
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006245854.5 → XP_006245916.1  meiosis regulator and mRNA stability factor 1 isoform X2

      UniProtKB/TrEMBL
      A6KU39
      Conserved Domains (10) summary
      cd09978
      Location:987 → 1057
      LOTUS_2_Limkain_b1; The second LOTUS domain on Limkain b1(LKAP)
      cd09979
      Location:1083 → 1154
      LOTUS_3_Limkain_b1; The third LOTUS domain on Limkain b1(LKAP)
      cd09980
      Location:1159 → 1230
      LOTUS_4_Limkain_b1; The fourth LOTUS domain on Limkain b1(LKAP)
      cd09981
      Location:1243 → 1313
      LOTUS_5_Limkain_b1; The fifth LOTUS domain on Limkain b1(LKAP)
      cd09983
      Location:1395 → 1467
      LOTUS_7_Limkain_b1; The seventh LOTUS domain on Limkain b1(LKAP)
      cd09984
      Location:1470 → 1545
      LOTUS_8_Limkain_b1; The eighth LOTUS domain on Limkain b1(LKAP)
      cd10910
      Location:350 → 492
      limkain_b1_N_like; N-terminal LabA-like domain of limkain b1 and similar proteins
      cd12255
      Location:507 → 579
      RRM1_LKAP; RNA recognition motif 1 in Limkain-b1 (LKAP) and similar proteins
      cd12256
      Location:770 → 858
      RRM2_LKAP; RNA recognition motif 2 in Limkain-b1 (LKAP) and similar proteins
      cl14879
      Location:1319 → 1389
      LabA_like_C; C-terminal domain of LabA_like proteins

    2. XM_006245856.5 → XP_006245918.1  meiosis regulator and mRNA stability factor 1 isoform X4

      UniProtKB/TrEMBL
      A6KU39
      Conserved Domains (10) summary
      cd09978
      Location:822 → 892
      LOTUS_2_Limkain_b1; The second LOTUS domain on Limkain b1(LKAP)
      cd09979
      Location:918 → 989
      LOTUS_3_Limkain_b1; The third LOTUS domain on Limkain b1(LKAP)
      cd09980
      Location:994 → 1065
      LOTUS_4_Limkain_b1; The fourth LOTUS domain on Limkain b1(LKAP)
      cd09981
      Location:1078 → 1148
      LOTUS_5_Limkain_b1; The fifth LOTUS domain on Limkain b1(LKAP)
      cd09983
      Location:1230 → 1302
      LOTUS_7_Limkain_b1; The seventh LOTUS domain on Limkain b1(LKAP)
      cd09984
      Location:1305 → 1380
      LOTUS_8_Limkain_b1; The eighth LOTUS domain on Limkain b1(LKAP)
      cd10910
      Location:171 → 313
      limkain_b1_N_like; N-terminal LabA-like domain of limkain b1 and similar proteins
      cd12255
      Location:328 → 400
      RRM1_LKAP; RNA recognition motif 1 in Limkain-b1 (LKAP) and similar proteins
      cd12256
      Location:605 → 693
      RRM2_LKAP; RNA recognition motif 2 in Limkain-b1 (LKAP) and similar proteins
      cl14879
      Location:1154 → 1224
      LabA_like_C; C-terminal domain of LabA_like proteins

    3. XM_063268363.1 → XP_063124433.1  meiosis regulator and mRNA stability factor 1 isoform X5

      UniProtKB/TrEMBL
      A6KU39

    4. XM_063268364.1 → XP_063124434.1  meiosis regulator and mRNA stability factor 1 isoform X6

    5. XM_063268362.1 → XP_063124432.1  meiosis regulator and mRNA stability factor 1 isoform X3

      UniProtKB/TrEMBL
      A0A0G2K0S5, A6KU39

    6. XM_003750779.6 → XP_003750827.1  meiosis regulator and mRNA stability factor 1 isoform X1

      See identical proteins and their annotated locations for XP_003750827.1

      UniProtKB/Swiss-Prot
      F1LNE9, Q8VIG2
      UniProtKB/TrEMBL
      A6KU39
      Conserved Domains (10) summary
      cd09978
      Location:1001 → 1071
      LOTUS_2_Limkain_b1; The second LOTUS domain on Limkain b1(LKAP)
      cd09979
      Location:1097 → 1168
      LOTUS_3_Limkain_b1; The third LOTUS domain on Limkain b1(LKAP)
      cd09980
      Location:1173 → 1244
      LOTUS_4_Limkain_b1; The fourth LOTUS domain on Limkain b1(LKAP)
      cd09981
      Location:1257 → 1327
      LOTUS_5_Limkain_b1; The fifth LOTUS domain on Limkain b1(LKAP)
      cd09983
      Location:1409 → 1481
      LOTUS_7_Limkain_b1; The seventh LOTUS domain on Limkain b1(LKAP)
      cd09984
      Location:1484 → 1559
      LOTUS_8_Limkain_b1; The eighth LOTUS domain on Limkain b1(LKAP)
      cd10910
      Location:350 → 492
      limkain_b1_N_like; N-terminal LabA-like domain of limkain b1 and similar proteins
      cd12255
      Location:507 → 579
      RRM1_LKAP; RNA recognition motif 1 in Limkain-b1 (LKAP) and similar proteins
      cd12256
      Location:784 → 872
      RRM2_LKAP; RNA recognition motif 2 in Limkain-b1 (LKAP) and similar proteins
      cl14879
      Location:1333 → 1403
      LabA_like_C; C-terminal domain of LabA_like proteins

    7. XM_006245855.5 → XP_006245917.1  meiosis regulator and mRNA stability factor 1 isoform X3

      See identical proteins and their annotated locations for XP_006245917.1

      UniProtKB/TrEMBL
      A0A0G2K0S5, A6KU39
      Related
      ENSRNOP00000071564.2, ENSRNOT00000077828.3
      Conserved Domains (10) summary
      cd09978
      Location:955 → 1025
      LOTUS_2_Limkain_b1; The second LOTUS domain on Limkain b1(LKAP)
      cd09979
      Location:1051 → 1122
      LOTUS_3_Limkain_b1; The third LOTUS domain on Limkain b1(LKAP)
      cd09980
      Location:1127 → 1198
      LOTUS_4_Limkain_b1; The fourth LOTUS domain on Limkain b1(LKAP)
      cd09981
      Location:1211 → 1281
      LOTUS_5_Limkain_b1; The fifth LOTUS domain on Limkain b1(LKAP)
      cd09983
      Location:1363 → 1435
      LOTUS_7_Limkain_b1; The seventh LOTUS domain on Limkain b1(LKAP)
      cd09984
      Location:1438 → 1513
      LOTUS_8_Limkain_b1; The eighth LOTUS domain on Limkain b1(LKAP)
      cd10910
      Location:304 → 446
      limkain_b1_N_like; N-terminal LabA-like domain of limkain b1 and similar proteins
      cd12255
      Location:461 → 533
      RRM1_LKAP; RNA recognition motif 1 in Limkain-b1 (LKAP) and similar proteins
      cd12256
      Location:738 → 826
      RRM2_LKAP; RNA recognition motif 2 in Limkain-b1 (LKAP) and similar proteins
      cl14879
      Location:1287 → 1357
      LabA_like_C; C-terminal domain of LabA_like proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VIG2.2 GenPept UniProtKB/Swiss-Prot:Q8VIG2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools