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    Inhca inhibitor of carbonic anhydrase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 315963, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Inhcaprovided by RGD
    Official Full Name
    inhibitor of carbonic anhydraseprovided by RGD
    Primary source
    RGD:1310507
    See related
    EnsemblRapid:ENSRNOG00000009434 AllianceGenome:RGD:1310507
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Aa2-001; LRRGT00077; LRRGT00161; RGD1310507
    Summary
    Predicted to enable enzyme inhibitor activity. Predicted to be involved in antibacterial humoral response and iron ion transport. Predicted to be active in endosome; extracellular space; and plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 5483.1) See more
    Orthologs
    mouse all
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    Genomic context

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    See Inhca in Genome Data Viewer
    Location:
    8q32
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (112715733..112753950, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (103836846..103874980, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (111742987..111762747, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480223 Neighboring gene transferrin Neighboring gene uncharacterized LOC134480224 Neighboring gene uncharacterized LOC120094247 Neighboring gene DNA topoisomerase II binding protein 1 Neighboring gene carnitine deficiency-associated gene expressed in ventricle 3 Neighboring gene uncharacterized LOC102550226

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables enzyme inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT enables iron ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in antibacterial humoral response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in iron ion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in early endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in recycling endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Inhibitor of carbonic anhydrase; inhibitor of carbonic anhydrase
    Names
    Inhibitor of carbonic anhydrase-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001047891.2 → NP_001041356.2  Inhibitor of carbonic anhydrase precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A8I6AEF9, A0A8I6AHP0
      Related
      ENSRNOP00000074521.3, ENSRNOT00000083855.3
      Conserved Domains (2) summary
      cd13617
      Location:352 → 684
      PBP2_transferrin_C; The C-lobe of transferrin, a member of the type 2 periplasmic binding protein fold superfamily
      cd13618
      Location:24 → 346
      PBP2_transferrin_N; The N-lobe of transferrin, a member of the type 2 periplasmic binding protein fold superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      112715733..112753950 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063265605.1 → XP_063121675.1  inhibitor of carbonic anhydrase isoform X3

      UniProtKB/TrEMBL
      A0A8I6AHP0

    2. XM_039081555.2 → XP_038937483.1  inhibitor of carbonic anhydrase isoform X1

      UniProtKB/TrEMBL
      A0A0G2K896, A0A8I6AHP0
      Related
      ENSRNOP00000090502.2, ENSRNOT00000108282.2
      Conserved Domains (2) summary
      cd13617
      Location:367 → 699
      PBP2_transferrin_C; The C-lobe of transferrin, a member of the type 2 periplasmic binding protein fold superfamily
      cd13618
      Location:39 → 361
      PBP2_transferrin_N; The N-lobe of transferrin, a member of the type 2 periplasmic binding protein fold superfamily

    3. XM_039081556.2 → XP_038937484.1  inhibitor of carbonic anhydrase isoform X2

      UniProtKB/TrEMBL
      A0A8I6AHP0
      Conserved Domains (2) summary
      cd13617
      Location:353 → 685
      PBP2_transferrin_C; The C-lobe of transferrin, a member of the type 2 periplasmic binding protein fold superfamily
      cd13618
      Location:39 → 347
      PBP2_transferrin_N; The N-lobe of transferrin, a member of the type 2 periplasmic binding protein fold superfamily
    Nucleotide Protein Strain
    Heading Accession and Version

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