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    Ccl27 C-C motif chemokine ligand 27 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362505, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Ccl27provided by RGD
    Official Full Name
    C-C motif chemokine ligand 27provided by RGD
    Primary source
    RGD:1304660
    See related
    EnsemblRapid:ENSRNOG00000039530 AllianceGenome:RGD:1304660
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable CCR3 chemokine receptor binding activity; CXCR chemokine receptor binding activity; and chemokine activity. Predicted to be involved in several processes, including antimicrobial humoral immune response mediated by antimicrobial peptide; cellular response to lipopolysaccharide; and neutrophil chemotaxis. Predicted to act upstream of or within regulation of actin cytoskeleton organization. Predicted to be active in extracellular space. Orthologous to human CCL27 (C-C motif chemokine ligand 27). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 40.3), Brain (RPKM 37.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ccl27 in Genome Data Viewer
    Location:
    5q22
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (61737261..61744375, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (56941402..56948511, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (58159066..58166182, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene sigma non-opioid intracellular receptor 1 Neighboring gene galactose-1-phosphate uridylyltransferase Neighboring gene interleukin 11 receptor subunit alpha 1 Neighboring gene uncharacterized LOC102547621 Neighboring gene similar to ribosomal protein S12 Neighboring gene C-C motif chemokine ligand 19

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Increased serum cutaneous T cell-attracting chemokine (CCL27) levels in patients with atopic dermatitis and psoriasis vulgaris. Kakinuma T, et al. J Allergy Clin Immunol, 2003 Mar. PMID 12642842
    2. TARC and RANTES, but not CTACK, are induced in two models of allergic contact dermatitis. Effects of cilomilast and diflorasone diacetate on T-cell-attracting chemokines. Bäumer W, et al. Br J Dermatol, 2004 Oct. PMID 15491423
    3. The chemokine ESkine/CCL27 displays novel modes of intracrine and paracrine function. Gortz A, et al. J Immunol, 2002 Aug 1. PMID 12133963
    4. CTACK, a skin-associated chemokine that preferentially attracts skin-homing memory T cells. Morales J, et al. Proc Natl Acad Sci U S A, 1999 Dec 7. PMID 10588729, Free PMC Article
    5. ESkine, a novel beta-chemokine, is differentially spliced to produce secretable and nuclear targeted isoforms. Baird JW, et al. J Biol Chem, 1999 Nov 19. PMID 10559234

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables CCR3 chemokine receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables CXCR chemokine receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chemokine activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chemokine activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cytokine activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in antimicrobial humoral immune response mediated by antimicrobial peptide IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in antimicrobial humoral immune response mediated by antimicrobial peptide ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in cell chemotaxis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to lipopolysaccharide IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neutrophil chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    C-C motif chemokine 27
    Names
    chemokine (C-C motif) ligand 27

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108660.1 → NP_001102130.1  C-C motif chemokine 27

      See identical proteins and their annotated locations for NP_001102130.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473962
      UniProtKB/TrEMBL
      A6IIX6, A6IIX8, D4AAL6
      Related
      ENSRNOP00000057330.2, ENSRNOT00000060594.4
      Conserved Domains (1) summary
      cl00134
      Location:76 → 128
      Chemokine; Chemokine: small cytokines, including a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; distinguished from other cytokines by their receptors, which are G-protein coupled receptors; divided ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      61737261..61744375 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008763627.4 → XP_008761849.1  C-C motif chemokine 27 isoform X2

      UniProtKB/TrEMBL
      A6IIX6
      Conserved Domains (1) summary
      cl00134
      Location:82 → 134
      Chemokine; Chemokine: small cytokines, including a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; distinguished from other cytokines by their receptors, which are G-protein coupled receptors; divided ...

    2. XM_006238074.5 → XP_006238136.1  C-C motif chemokine 27 isoform X1

      See identical proteins and their annotated locations for XP_006238136.1

      UniProtKB/TrEMBL
      A6IIX6
      Related
      ENSRNOP00000089578.2, ENSRNOT00000096308.2
      Conserved Domains (1) summary
      cl00134
      Location:97 → 149
      Chemokine; Chemokine: small cytokines, including a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; distinguished from other cytokines by their receptors, which are G-protein coupled receptors; divided ...

    3. XM_006238073.5 → XP_006238135.1  C-C motif chemokine 27 isoform X1

      See identical proteins and their annotated locations for XP_006238135.1

      UniProtKB/TrEMBL
      A6IIX6
      Conserved Domains (1) summary
      cl00134
      Location:97 → 149
      Chemokine; Chemokine: small cytokines, including a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; distinguished from other cytokines by their receptors, which are G-protein coupled receptors; divided ...

    4. XM_063287905.1 → XP_063143975.1  C-C motif chemokine 27 isoform X3

      UniProtKB/TrEMBL
      A6IIX6, A6IIX8, D4AAL6

    5. XM_006238077.5 → XP_006238139.1  C-C motif chemokine 27 isoform X3

      See identical proteins and their annotated locations for XP_006238139.1

      UniProtKB/TrEMBL
      A6IIX6, A6IIX8, D4AAL6
      Conserved Domains (1) summary
      cl00134
      Location:76 → 128
      Chemokine; Chemokine: small cytokines, including a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; distinguished from other cytokines by their receptors, which are G-protein coupled receptors; divided ...

    6. XM_063287904.1 → XP_063143974.1  C-C motif chemokine 27 isoform X3

      UniProtKB/TrEMBL
      A6IIX6, A6IIX8, D4AAL6
      Related
      ENSRNOP00000101991.1, ENSRNOT00000124928.1

    7. XM_006238081.2 → XP_006238143.1  C-C motif chemokine 27 isoform X4

      See identical proteins and their annotated locations for XP_006238143.1

      UniProtKB/TrEMBL
      A6IIY3
      Conserved Domains (1) summary
      pfam00048
      Location:31 → 91
      IL8; Small cytokines (intecrine/chemokine), interleukin-8 like

    8. XM_063287907.1 → XP_063143977.1  C-C motif chemokine 27 isoform X5

      UniProtKB/TrEMBL
      A0A8I6AC23

    9. XM_017593471.3 → XP_017448960.1  C-C motif chemokine 27 isoform X5

      UniProtKB/TrEMBL
      A0A8I6AC23

    10. XM_039110225.2 → XP_038966153.1  C-C motif chemokine 27 isoform X6

      UniProtKB/TrEMBL
      A6IIY5
    Nucleotide Protein Strain
    Heading Accession and Version

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