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    Ins1 insulin 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24505, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ins1provided by RGD
    Official Full Name
    insulin 1provided by RGD
    Primary source
    RGD:2915
    See related
    EnsemblRapid:ENSRNOG00000012052 AllianceGenome:RGD:2915
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables insulin receptor binding activity. Involved in several processes, including cellular response to glucose stimulus; response to cAMP; and response to dimethyl sulfoxide. Located in extracellular space. Biomarker of Alzheimer's disease. Human ortholog(s) of this gene implicated in diabetic retinopathy; glucose metabolism disease (multiple); insulinoma; and pancreatic cancer. Orthologous to several human genes including INS (insulin). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 128.8) and Liver (RPKM 39.5) See more
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    Genomic context

    See Ins1 in Genome Data Viewer
    Location:
    1q55
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (261186119..261186686)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (251244973..251245540)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (272799784..272800351)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene hypothetical protein LOC679558 Neighboring gene nucleoporin 133, pseudogene 1 Neighboring gene uncharacterized LOC134485248 Neighboring gene olfactory receptor 385 Neighboring gene uncharacterized LOC134484924

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables hormone activity  
    enables insulin receptor binding  
    enables insulin receptor binding PubMed 
    Component Evidence Code Pubs
    located_in cytosol  
    is_active_in extracellular space  
    located_in extracellular space PubMed 
    is_active_in extracellular space  

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019129.3NP_062002.1  insulin-1 preproprotein

      See identical proteins and their annotated locations for NP_062002.1

      Status: VALIDATED

      Source sequence(s)
      BP465191, BP502578
      UniProtKB/Swiss-Prot
      P01322
      UniProtKB/TrEMBL
      A6JHT1, A6JHT2
      Related
      ENSRNOP00000016052.3, ENSRNOT00000016052.7
      Conserved Domains (1) summary
      cd04367
      Location:26110
      IlGF_insulin_like; IlGF_like family, insulin_like subgroup, specific to vertebrates. Members include a number of peptides including insulin and insulin-like growth factors I and II, which play a variety of roles in controlling processes such as metabolism, growth and ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      261186119..261186686
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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