Arpc1b actin related protein 2/3 complex, subunit 1B [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Arpc1bprovided by RGD
Official Full Name: actin related protein 2/3 complex, subunit 1Bprovided by RGD
Primary source: RGD:2155
See related: EnsemblRapid:ENSRNOG00000000991 AllianceGenome:RGD:2155
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: p41Arc
Summary: Predicted to enable actin filament binding activity. Predicted to be a structural constituent of cytoskeleton. Involved in response to estradiol and response to estrogen. Part of tubulobulbar complex. Human ortholog(s) of this gene implicated in gastritis; immunodeficiency 71; and myelodysplastic syndrome. Orthologous to human ARPC1B (actin related protein 2/3 complex subunit 1B). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 1327.1), Thymus (RPKM 1077.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 12p11

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (14595939..14609501, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (9482176..9495772, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (11252300..11265849, complement)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results expand the model of insulin-stimulated glucose uptake in skeletal muscle cells by implicating p41ARC as a new component of the insulin-signaling cascade and connecting PAK1 signaling to N-WASP-cortactin-mediated actin polymerization and GLUT4 vesicle translocation.
Title: The actin-related p41ARC subunit contributes to p21-activated kinase-1 (PAK1)-mediated glucose uptake into skeletal muscle cells.
Arpc1b knockdown in adult rat testis led to defects in spermiation caused by failure in Sertoli-cell tubulobulbar complexes formation. Knockdown also compromised blood-testis barrier integrity and caused polarity defects of mature spermatids. Arpc1b reduction perturbed ability of germ cells to enter G2/M phase thus hindering cell division.
Title: Actin related protein complex subunit 1b controls sperm release, barrier integrity and cell division during adult rat spermatogenesis.
Data suggest that expression of spermiation-related genes is directly up-regulated by estrogen 17-beta-estradiol in testes of adult rats; a functional estrogen response element lies upstream of Arpc1b and Evl genes. (Arpc1b = actin related protein 2-3 complex, subunit 1B; Evl = enabled-VASP-like protein)
Title: Direct regulation of genes involved in sperm release by estrogen and androgen through their receptors and coregulators.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AW208418 (e-PCR)
- UniSTS:165440

RH127787 (e-PCR)
- UniSTS:211097

RH129626 (e-PCR)
- UniSTS:212923

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
contributes_to actin filament binding	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed
enables structural constituent of cytoskeleton	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Arp2/3 complex-mediated actin nucleation	IBA Inferred from Biological aspect of Ancestor more info
involved_in Arp2/3 complex-mediated actin nucleation	IEA Inferred from Electronic Annotation more info
involved_in Arp2/3 complex-mediated actin nucleation	ISO Inferred from Sequence Orthology more info
involved_in response to estradiol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to estrogen	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
part_of Arp2/3 protein complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Arp2/3 protein complex	IEA Inferred from Electronic Annotation more info
part_of Arp2/3 protein complex	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of tubulobulbar complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: actin-related protein 2/3 complex subunit 1B

Names: Actin-related protein complex 1b; arp2/3 complex 41 kDa subunit; p41-ARC

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019289.3 → NP_062162.1 actin-related protein 2/3 complex subunit 1B

See identical proteins and their annotated locations for NP_062162.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000012

UniProtKB/Swiss-Prot

O88656

UniProtKB/TrEMBL

A0A8L2Q086, A6K1G1

Related

ENSRNOP00000091680.2, ENSRNOT00000114214.2

Conserved Domains (2) summary

sd00039
Location:11 → 50

7WD40; WD40 repeat [structural motif]

cl29593
Location:45 → 264

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086030.1 Reference GRCr8

Range

14595939..14609501 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039089713.2 → XP_038945641.1 actin-related protein 2/3 complex subunit 1B isoform X1

UniProtKB/Swiss-Prot

O88656

UniProtKB/TrEMBL

A0A8L2Q086, A6K1G1

Conserved Domains (2) summary

sd00039
Location:11 → 50

7WD40; WD40 repeat [structural motif]

cl29593
Location:45 → 264

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...