Dlc1 DLC1 Rho GTPase activating protein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dlc1provided by RGD
Official Full Name: DLC1 Rho GTPase activating proteinprovided by RGD
Primary source: RGD:68416
See related: EnsemblRapid:ENSRNOG00000010780 AllianceGenome:RGD:68416
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RhoGAP; Arhgap7
Summary: Enables enzyme activator activity; phospholipase binding activity; and vinculin binding activity. Involved in cellular response to insulin stimulus. Located in actin filament; focal adhesion; and stress fiber. Human ortholog(s) of this gene implicated in colorectal cancer. Orthologous to human DLC1 (DLC1 Rho GTPase activating protein). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 261.3), Heart (RPKM 244.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 16q12.1-q12.2

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	16	NC_086034.1 (61954177..62374819)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	16	NC_051351.1 (55246716..55671441)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	16	NC_005115.4 (58776489..59247752)

Chromosome 16 - NC_086034.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Our work then defines RhoGAP p190A as a new mediator of RhoA activation by ANG II in vascular smooth muscle cells.
Title: Angiotensin II induces RhoA activation through SHP2-dependent dephosphorylation of the RhoGAP p190A in vascular smooth muscle cells.
in PC12 cells PLCdelta1 is recruited to lipid rafts and binds to preexisting p122 in Ca2+ dependent manner. This process can be triggered by muscarinic stimuli.
Title: Recruitment and activation of phospholipase C (PLC)-delta1 in lipid rafts by muscarinic stimulation of PC12 cells: contribution of p122RhoGAP/DLC1, a tumor-suppressing PLCdelta1 binding protein.
p122RhoGAP Ser-322 acts as an integrator of signal transduction in a manner dependent on the cellular context and is a substrate for protein kinase B and ribosomal S6 kinase
Title: Identification of p122RhoGAP (deleted in liver cancer-1) Serine 322 as a substrate for protein kinase B and ribosomal S6 kinase in insulin-stimulated cells.
Cellular distribution of p122RhoGAP, a GTPase-activating protein of Rho small GTPase and an activator of phospholipase C-delta(1).
Title: A PLCdelta1-binding protein, p122RhoGAP, is localized in focal adhesions.

Submit: New GeneRIF Correction

General gene information

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Markers

AI104472 (e-PCR)
- UniSTS:250650

BE112293 (e-PCR)
- UniSTS:246081

BG374117 (e-PCR)
- UniSTS:249669

d16rat62 (e-PCR)
- UniSTS:121162

BI302233 (e-PCR)
- UniSTS:247627

D16Nkg55 (e-PCR)
- UniSTS:527773

D16Nkg54 (e-PCR)
- UniSTS:527779

D16Nkg56 (e-PCR)
- UniSTS:527797

BF402825 (e-PCR)
- UniSTS:245955

AI176713 (e-PCR)
- UniSTS:250322

MARC_21337-21338:1023126946:1 (e-PCR)
- UniSTS:268533

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GTPase activator activity	IDA Inferred from Direct Assay more info	PubMed
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info
NOT enables GTPase activator activity	ISO Inferred from Sequence Orthology more info
enables GTPase activator activity	ISO Inferred from Sequence Orthology more info
enables SH2 domain binding	IEA Inferred from Electronic Annotation more info
enables SH2 domain binding	ISO Inferred from Sequence Orthology more info
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables phospholipase C activator activity	IDA Inferred from Direct Assay more info	PubMed
enables phospholipase binding	IPI Inferred from Physical Interaction more info	PubMed
enables vinculin binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in cellular response to insulin stimulus	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within focal adhesion assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within forebrain development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within heart morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within hindbrain morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in intracellular signal transduction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of Rho protein signal transduction	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of Rho protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell migration	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of focal adhesion assembly	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of focal adhesion assembly	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of stress fiber assembly	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of stress fiber assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neural tube closure	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cysteine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of execution phase of apoptosis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of execution phase of apoptosis	ISO Inferred from Sequence Orthology more info
involved_in regulation of Rho protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in actin filament	IDA Inferred from Direct Assay more info	PubMed
located_in caveola	IEA Inferred from Electronic Annotation more info
located_in caveola	ISO Inferred from Sequence Orthology more info
located_in cortical actin cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cortical actin cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
is_active_in focal adhesion	IBA Inferred from Biological aspect of Ancestor more info
located_in focal adhesion	IDA Inferred from Direct Assay more info	PubMed
located_in focal adhesion	IEA Inferred from Electronic Annotation more info
located_in focal adhesion	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in membrane raft	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in ruffle membrane	IEA Inferred from Electronic Annotation more info
located_in ruffle membrane	ISO Inferred from Sequence Orthology more info
located_in stress fiber	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: rho GTPase-activating protein 7

Names: START domain-containing protein 12; deleted in liver cancer 1 protein homolog; dlc-1; p122-RhoGAP; rho-type GTPase-activating protein 7; stAR-related lipid transfer protein 12; stARD12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001127446.1 → NP_001120918.1 rho GTPase-activating protein 7 isoform 2

See identical proteins and their annotated locations for NP_001120918.1

Status: PROVISIONAL

Description

Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.

Source sequence(s)

JAXUCZ010000016

UniProtKB/Swiss-Prot

Q63744

UniProtKB/TrEMBL

A0A0G2K9I2, A6IVJ9

Related

ENSRNOP00000075006.2, ENSRNOT00000090477.4

Conserved Domains (3) summary

cd09591
Location:17 → 76

SAM_DLC1; SAM domain of DLC1 subfamily

cd04375
Location:635 → 853

RhoGAP_DLC1; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START ...

cl14643
Location:878 → 1081

SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily
NM_001370997.1 → NP_001357926.1 rho GTPase-activating protein 7 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

JAXUCZ010000016

UniProtKB/TrEMBL

A0A8I5ZJE0

Related

ENSRNOP00000077109.1, ENSRNOT00000104961.2

Conserved Domains (3) summary

cd09591
Location:468 → 527

SAM_DLC1; SAM domain of DLC1 subfamily

cd04375
Location:1086 → 1304

RhoGAP_DLC1; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START ...

cl14643
Location:1329 → 1532

SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086034.1 Reference GRCr8

Range

61954177..62374819

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039094797.2 → XP_038950725.1 rho GTPase-activating protein 7 isoform X1

UniProtKB/TrEMBL

A0A8I5ZJE0

Conserved Domains (3) summary

cd09591
Location:468 → 527

SAM_DLC1; SAM domain of DLC1 subfamily

cd04375
Location:1086 → 1304

RhoGAP_DLC1; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START ...

cl14643
Location:1329 → 1532

SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily
XM_063275674.1 → XP_063131744.1 rho GTPase-activating protein 7 isoform X5
XM_063275672.1 → XP_063131742.1 rho GTPase-activating protein 7 isoform X4
XM_063275673.1 → XP_063131743.1 rho GTPase-activating protein 7 isoform X5
XM_017600236.3 → XP_017455725.1 rho GTPase-activating protein 7 isoform X1

UniProtKB/TrEMBL

A0A8I5ZJE0

Conserved Domains (3) summary

cd09591
Location:468 → 527

SAM_DLC1; SAM domain of DLC1 subfamily

cd04375
Location:1086 → 1304

RhoGAP_DLC1; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START ...

cl14643
Location:1329 → 1532

SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily
XM_039094798.2 → XP_038950726.1 rho GTPase-activating protein 7 isoform X2

UniProtKB/Swiss-Prot

Q63744

UniProtKB/TrEMBL

A0A8I6AX28

Related

ENSRNOP00000014923.5, ENSRNOT00000014924.5

Conserved Domains (3) summary

cd09591
Location:51 → 110

SAM_DLC1; SAM domain of DLC1 subfamily

cd04375
Location:669 → 887

RhoGAP_DLC1; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START ...

cl14643
Location:912 → 1115

SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily
XM_039094799.2 → XP_038950727.1 rho GTPase-activating protein 7 isoform X3

UniProtKB/Swiss-Prot

Q63744

Related

ENSRNOP00000097976.2, ENSRNOT00000106416.2

Conserved Domains (3) summary

cd09591
Location:36 → 95

SAM_DLC1; SAM domain of DLC1 subfamily

cd04375
Location:654 → 872

RhoGAP_DLC1; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START ...

cl14643
Location:897 → 1100

SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily