Gabrb2 gamma-aminobutyric acid type A receptor subunit beta 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gabrb2provided by RGD
Official Full Name: gamma-aminobutyric acid type A receptor subunit beta 2provided by RGD
Primary source: RGD:2650
See related: EnsemblRapid:ENSRNOG00000003680 AllianceGenome:RGD:2650
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: GARB2
Summary: Enables GABA-A receptor activity and monoatomic ion channel activity. Contributes to GABA receptor activity. Involved in GABAergic synaptic transmission; cellular response to histamine; and chloride transmembrane transport. Located in plasma membrane. Part of GABA-A receptor complex. Is active in GABA-ergic synapse; glutamatergic synapse; and synaptic membrane. Human ortholog(s) of this gene implicated in autistic disorder and developmental and epileptic encephalopathy 92. Orthologous to human GABRB2 (gamma-aminobutyric acid type A receptor subunit beta2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 272.9) See more
Orthologs: human mouse all
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Genomic context

Location:: 10q21

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (27438127..27657680)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (26936592..27156141)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (27973694..28193072)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The beta2 subunit E155 residue as a proton sensor at the binding site on GABA type A receptors.
Title: The β(2) subunit E155 residue as a proton sensor at the binding site on GABA type A receptors.
Intrasubunit and Intersubunit Steroid Binding Sites Independently and Additively Mediate alpha1beta2gamma2L GABAA Receptor Potentiation by the Endogenous Neurosteroid Allopregnanolone.
Title: Intrasubunit and Intersubunit Steroid Binding Sites Independently and Additively Mediate α1β2γ2L GABA(A) Receptor Potentiation by the Endogenous Neurosteroid Allopregnanolone.
In inhibitory transmission onto hippocampal CA1 pyramidal cells, deletion of all beta subunits 1, 2, and 3 completely eliminated inhibitory responses. In addition, only knockout of beta3, alone or in combination with another beta subunit, impaired inhibitory synaptic transmission. expression of beta3 alone on the background of the beta1-3 subunit knockout was sufficient to restore synaptic and extrasynaptic inhibitory ...
Title: The GABA(A) Receptor β Subunit Is Required for Inhibitory Transmission.
the subunit arrangement of alpha4beta2delta GABAA receptors is not strongly predefined but is mostly satisfying the 2:2:1 subunit stoichiometry for alpha4, beta2, and delta subunits and that several subunit arrangements result in receptors with similar functional properties tuned to physiological conditions.
Title: Toward Understanding Functional Properties and Subunit Arrangement of α4β2δ γ-Aminobutyric Acid, Type A (GABAA) Receptors.
The data of this study reveal that GABAA receptor beta2 and beta3 decrease following 1 h of acute restraint stress and may play a critical role in stress-induced hyperalgesia.
Title: Role of spinal GABAA receptor reduction induced by stress in rat thermal hyperalgesia.
These studies identify a novel gephyrin-binding motif in GABA(A) R beta2 and beta3 large cytoplasmic loops.
Title: Direct binding of GABAA receptor β2 and β3 subunits to gephyrin.
The interaction between midazolam and propofol is affected by receptor subtype, and protein kinase phosphorylation influences their interaction on the alpha(1)beta(2)gamma(2)L receptor.
Title: Interactions of midazolam and propofol on α1β2γ2L and α1β2γ2S gamma aminobutyric acid type A receptors expressed in human embryonic kidney cells.
Ligand- and subunit-specific conformational changes in the ligand-binding domain and the TM2-TM3 linker of {alpha}1 {beta}2 {gamma}2 GABAA receptors.
Title: Ligand- and subunit-specific conformational changes in the ligand-binding domain and the TM2-TM3 linker of {alpha}1 {beta}2 {gamma}2 GABAA receptors.
Results indicate that beta2 Loop 9 is involved in receptor activation by GABA, propofol, and pregnanolone and that beta2(Q185) participates in hydrophilic interactions that are important for stabilizing the closed state of the GABA(A) receptor.
Title: A residue in loop 9 of the beta2-subunit stabilizes the closed state of the GABAA receptor.
the density of surface clusters of GABA(A)R beta2/3 subunits was reduced by D(4), suggesting that the D(4) reduction of GABA(A)R current is associated with a decrease in functional GABA(A)Rs at the plasma membrane.
Title: Dopamine D4 Receptors Regulate GABAA Receptor Trafficking via an Actin/Cofilin/Myosin-dependent Mechanism.

Submit: New GeneRIF Correction See all GeneRIFs (24)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
contributes_to GABA receptor activity	IDA Inferred from Direct Assay more info	PubMed
contributes_to GABA receptor activity	ISO Inferred from Sequence Orthology more info
enables GABA-A receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables GABA-A receptor activity	IEA Inferred from Electronic Annotation more info
enables GABA-A receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables GABA-A receptor activity	TAS Traceable Author Statement more info	PubMed
enables GABA-gated chloride ion channel activity	IEA Inferred from Electronic Annotation more info
contributes_to GABA-gated chloride ion channel activity	ISO Inferred from Sequence Orthology more info
contributes_to GABA-gated chloride ion channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables chloride channel activity	IEA Inferred from Electronic Annotation more info
enables chloride channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables extracellular ligand-gated monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables inhibitory extracellular ligand-gated monoatomic ion channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	IDA Inferred from Direct Assay more info	PubMed
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	IMP Inferred from Mutant Phenotype more info	PubMed
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	NAS Non-traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IEA Inferred from Electronic Annotation more info
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular response to histamine	IDA Inferred from Direct Assay more info	PubMed
involved_in chloride transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in chloride transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in chloride transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chloride transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in cochlea development	IEA Inferred from Electronic Annotation more info
involved_in cochlea development	ISO Inferred from Sequence Orthology more info
involved_in gamma-aminobutyric acid signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in gamma-aminobutyric acid signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in gamma-aminobutyric acid signaling pathway	NAS Non-traceable Author Statement more info	PubMed
involved_in gamma-aminobutyric acid signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in inhibitory synapse assembly	IEA Inferred from Electronic Annotation more info
involved_in inhibitory synapse assembly	ISO Inferred from Sequence Orthology more info
involved_in inhibitory synapse assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in inner ear receptor cell development	IEA Inferred from Electronic Annotation more info
involved_in inner ear receptor cell development	ISO Inferred from Sequence Orthology more info
involved_in innervation	IEA Inferred from Electronic Annotation more info
involved_in innervation	ISO Inferred from Sequence Orthology more info
involved_in neuron development	ISO Inferred from Sequence Orthology more info
involved_in regulation of postsynaptic membrane potential	IEA Inferred from Electronic Annotation more info
involved_in regulation of presynaptic membrane potential	IEA Inferred from Electronic Annotation more info
involved_in synaptic transmission, GABAergic	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of GABA receptor complex	IDA Inferred from Direct Assay more info	PubMed
part_of GABA-A receptor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of GABA-A receptor complex	IEA Inferred from Electronic Annotation more info
part_of GABA-A receptor complex	IMP Inferred from Mutant Phenotype more info	PubMed
part_of GABA-A receptor complex	ISO Inferred from Sequence Orthology more info
part_of GABA-A receptor complex	ISS Inferred from Sequence or Structural Similarity more info
is_active_in GABA-ergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in GABA-ergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in GABA-ergic synapse	ISO Inferred from Sequence Orthology more info
part_of chloride channel complex	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle membrane	IEA Inferred from Electronic Annotation more info
located_in dendritic spine	IEA Inferred from Electronic Annotation more info
is_active_in dendritic spine	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	TAS Traceable Author Statement more info
located_in postsynaptic membrane	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic specialization membrane	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic specialization membrane	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic specialization membrane	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic specialization membrane	ISO Inferred from Sequence Orthology more info
is_active_in presynaptic active zone membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: gamma-aminobutyric acid receptor subunit beta-2

Names: GABA(A) receptor subunit beta-2; GABAAR subunit beta-2; Gamma-aminobutyric acid receptor beta 2; gamma-aminobutyric acid (GABA) A receptor, beta 2; gamma-aminobutyric acid (GABA-A) receptor, subunit beta 2; gamma-aminobutyric acid type A receptor beta 2 subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001430104.1 → NP_001417033.1 gamma-aminobutyric acid receptor subunit beta-2 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/Swiss-Prot

P63138

UniProtKB/TrEMBL

A0A8I6AGU9, A6HDL9
NM_012957.3 → NP_037089.1 gamma-aminobutyric acid receptor subunit beta-2 precursor

See identical proteins and their annotated locations for NP_037089.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/Swiss-Prot

P63138

UniProtKB/TrEMBL

A0A8I6AGU9, A6HDL9

Conserved Domains (1) summary

TIGR00860
Location:9 → 472

LIC; Cation transporter family protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

27438127..27657680

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006246127.4 → XP_006246189.1 gamma-aminobutyric acid receptor subunit beta-2 isoform X1

Related

ENSRNOP00000081083.1, ENSRNOT00000118632.2

Conserved Domains (1) summary

TIGR00860
Location:9 → 472

LIC; Cation transporter family protein
XM_008767635.4 → XP_008765857.1 gamma-aminobutyric acid receptor subunit beta-2 isoform X2

UniProtKB/TrEMBL

A0A8I6AGU9, A0A8L2Q2J9

Related

ENSRNOP00000004970.4, ENSRNOT00000004970.7

Conserved Domains (3) summary

TIGR00860
Location:9 → 504

LIC; Cation transporter family protein

pfam02931
Location:40 → 242

Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain

pfam02932
Location:249 → 501

Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region
XM_039085275.2 → XP_038941203.1 gamma-aminobutyric acid receptor subunit beta-2 isoform X1

Conserved Domains (1) summary

TIGR00860
Location:9 → 472

LIC; Cation transporter family protein