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    Exoc8 exocyst complex component 8 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 245709, updated on 4-Jan-2025

    Summary

    Official Symbol
    Exoc8provided by RGD
    Official Full Name
    exocyst complex component 8provided by RGD
    Primary source
    RGD:620245
    See related
    EnsemblRapid:ENSRNOG00000071599 AllianceGenome:RGD:620245
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Exo84
    Summary
    Predicted to enable phosphatidylinositol binding activity and small GTPase binding activity. Predicted to be involved in several processes, including Golgi to plasma membrane transport; endosome organization; and extracellular matrix disassembly. Predicted to act upstream of or within exocytosis. Located in cell leading edge. Part of exocyst. Orthologous to human EXOC8 (exocyst complex component 8). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
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    Genomic context

    See Exoc8 in Genome Data Viewer
    Location:
    19q12
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (69752387..69754876, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (52855010..52857499, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (57647305..57649794, complement)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene tripartite motif-containing 67 Neighboring gene 40S small subunit processome assembly factor 1 Neighboring gene glyceronephosphate O-acyltransferase Neighboring gene SprT-like N-terminal domain Neighboring gene egl-9 family hypoxia-inducible factor 1

    Genomic regions, transcripts, and products

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables phosphatidylinositol binding  
    enables small GTPase binding  
    Process Evidence Code Pubs
    involved_in Golgi to plasma membrane transport  
    involved_in endosome organization  
    acts_upstream_of_or_within exocytosis  
    involved_in exocytosis PubMed 
    involved_in extracellular matrix disassembly  
    involved_in protein localization  
    involved_in protein transport  
    Component Evidence Code Pubs
    located_in cell leading edge PubMed 
    part_of exocyst  
    part_of exocyst PubMed 
    part_of exocyst  
    located_in growth cone  
    located_in late endosome  
    located_in perinuclear region of cytoplasm  

    General protein information

    Preferred Names
    exocyst complex component 8
    Names
    exocyst complex 84 kDa subunit

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_139043.2NP_620612.1  exocyst complex component 8

      See identical proteins and their annotated locations for NP_620612.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/Swiss-Prot
      O54924
      UniProtKB/TrEMBL
      A6KJ24
      Related
      ENSRNOP00000026757.1, ENSRNOT00000026757.5
      Conserved Domains (4) summary
      cd01226
      Location:167279
      PH_RalBD_exo84; Exocyst complex 84-kDa subunit Ral-binding domain/Pleckstrin Homology (PH) domain
      pfam00169
      Location:174273
      PH; PH domain
      pfam08700
      Location:1397
      Vps51; Vps51/Vps67
      pfam16528
      Location:326531
      Exo84_C; Exocyst component 84 C-terminal

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      69752387..69754876 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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