Fn1 fibronectin 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Fn1provided by RGD
Official Full Name: fibronectin 1provided by RGD
Primary source: RGD:2624
See related: EnsemblRapid:ENSRNOG00000014288 AllianceGenome:RGD:2624
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: fn-1; FIBNEC
Summary: Enables mercury ion binding activity and protease binding activity. Involved in several processes, including cellular response to amyloid-beta; cellular response to mercury ion; and cellular response to platelet-derived growth factor stimulus. Located in basement membrane and extracellular space. Used to study diabetic angiopathy; hypertension; and renovascular hypertension. Biomarker of several diseases, including artery disease (multiple); calcium oxalate nephrolithiasis; iron deficiency anemia; membranoproliferative glomerulonephritis; and ureteral obstruction. Human ortholog(s) of this gene implicated in calcium oxalate nephrolithiasis; membranoproliferative glomerulonephritis; and spondylometaphyseal dysplasia corner fracture type. Orthologous to human FN1 (fibronectin 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Liver (RPKM 1817.5), Lung (RPKM 1002.6) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 9q33

Exon count:: 46

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (80645507..80714200, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (73196044..73264695, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (78900111..78969018, complement)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LncRNA-HOTAIR Inhibits H9c2 Apoptosis After Acute Myocardial Infarction via miR-206/FN1 Axis.
Title: LncRNA-HOTAIR Inhibits H9c2 Apoptosis After Acute Myocardial Infarction via miR-206/FN1 Axis.
Evaluation of Sertoli cell autophagy associated with laminin, fibronectin, and caspase-3 proteins' alteration, following testicular torsion rat.
Title: Evaluation of Sertoli cell autophagy associated with laminin, fibronectin, and caspase-3 proteins' alteration, following testicular torsion rat.
Fibronectin is essential for formation of fenestrae in endothelial cells of the fenestrated capillary.
Title: Fibronectin is essential for formation of fenestrae in endothelial cells of the fenestrated capillary.
Increased Fibronectin Impairs the Function of Excitatory/Inhibitory Synapses in Hirschsprung Disease.
Title: Increased Fibronectin Impairs the Function of Excitatory/Inhibitory Synapses in Hirschsprung Disease.
Our study thus demonstrates the new role of PTHrP in fibronectin up-regulation for the first time in glomerular mesangial cells. These data also provided new insights to guide development of therapy for glomerular sclerosis.
Title: Parathyroid hormone-related protein induces fibronectin up-regulation in rat mesangial cells through reactive oxygen species/Src/EGFR signaling.
MRTF-A overexpression synergistically enhanced the induction of FN and ICAM-1 by Advanced glycation end products.
Title: MRTF-A mediated FN and ICAM-1 expression in AGEs-induced rat glomerular mesangial cells via activating STAT5.
PTH pretreatment prevented TGF-beta1 and high glucose-induced Smad2/3 phosphorylation and consequent upregulation of fibronectin and type IV collagen within 4 h.
Title: Parathyroid hormone inhibits TGF-β/Smad signaling and extracellular matrix proteins upregulation in rat mesangial cells.
these findings indicated that fibronectin expression is an early and progressive event that occurs during liver fibrogenesis in vivo and in vitro.
Title: Fibronectin expression is critical for liver fibrogenesis in vivo and in vitro.
this study shows that experimental iabetes interferes with the osseointegration of implants by deferring expression of fibronectin and integrin alpha5beta1
Title: Potential mechanism for osseointegration of dental implants in Zucker diabetic fatty rats.
overexpression of miRNA-21 counteracts the inhibitory effect of BMP-7 on TGF-beta1-induced fibronectin secretion and apoptosis.
Title: BMP-7 Attenuates TGF-β1-Induced Fibronectin Secretion and Apoptosis of NRK-52E Cells by the Suppression of miRNA-21.

Submit: New GeneRIF Correction See all GeneRIFs (64)

General gene information

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Markers

Fn1 (e-PCR), detects polymorphism
- UniSTS:462628

PMC151804P1 (e-PCR)
- UniSTS:271175

PMC151804P2 (e-PCR)
- UniSTS:271176

FN1 (e-PCR), detects polymorphism
- UniSTS:264012

RH127568 (e-PCR)
- UniSTS:210878

RH139076 (e-PCR)
- UniSTS:221162

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables extracellular matrix structural constituent	TAS Traceable Author Statement more info	PubMed
enables heparin binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables integrin binding	IBA Inferred from Biological aspect of Ancestor more info
enables integrin binding	IEA Inferred from Electronic Annotation more info
enables integrin binding	ISO Inferred from Sequence Orthology more info
enables mercury ion binding	IDA Inferred from Direct Assay more info	PubMed
enables peptidase activator activity	IEA Inferred from Electronic Annotation more info
enables peptidase activator activity	ISO Inferred from Sequence Orthology more info
enables protease binding	IEA Inferred from Electronic Annotation more info
enables protease binding	IPI Inferred from Physical Interaction more info	PubMed
enables protease binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables proteoglycan binding	IBA Inferred from Biological aspect of Ancestor more info
enables proteoglycan binding	IEA Inferred from Electronic Annotation more info
enables proteoglycan binding	ISO Inferred from Sequence Orthology more info
enables receptor ligand activity	IEA Inferred from Electronic Annotation more info
enables receptor ligand activity	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in acute-phase response	IEA Inferred from Electronic Annotation more info
involved_in angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in biological process involved in interaction with symbiont	IEA Inferred from Electronic Annotation more info
involved_in calcium-independent cell-matrix adhesion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within calcium-independent cell-matrix adhesion	ISO Inferred from Sequence Orthology more info
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in cell-matrix adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-matrix adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell-matrix adhesion	ISO Inferred from Sequence Orthology more info
involved_in cell-substrate junction assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-substrate junction assembly	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell-substrate junction assembly	ISO Inferred from Sequence Orthology more info
involved_in cellular response to BMP stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to amyloid-beta	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to angiotensin	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to glucose stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to interleukin-1	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to mercury ion	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to platelet-derived growth factor stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to prostaglandin E stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to transforming growth factor beta stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to vascular endothelial growth factor stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in endodermal cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in endodermal cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in extracellular matrix organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glial cell migration	IDA Inferred from Direct Assay more info	PubMed
involved_in heart development	IBA Inferred from Biological aspect of Ancestor more info
involved_in integrin activation	IEA Inferred from Electronic Annotation more info
involved_in integrin activation	ISO Inferred from Sequence Orthology more info
involved_in integrin-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in integrin-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of collagen biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of monocyte activation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of monocyte activation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transforming growth factor beta production	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transforming growth factor beta production	ISO Inferred from Sequence Orthology more info
involved_in nervous system development	IBA Inferred from Biological aspect of Ancestor more info
involved_in neural crest cell migration involved in autonomic nervous system development	IEA Inferred from Electronic Annotation more info
involved_in neural crest cell migration involved in autonomic nervous system development	ISO Inferred from Sequence Orthology more info
involved_in ossification	TAS Traceable Author Statement more info	PubMed
involved_in peptide cross-linking	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of axon extension	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of axon extension	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of chemotaxis	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of fibroblast proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of fibroblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of substrate-dependent cell migration, cell attachment to substrate	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of substrate-dependent cell migration, cell attachment to substrate	ISO Inferred from Sequence Orthology more info
involved_in regulation of ERK1 and ERK2 cascade	IEA Inferred from Electronic Annotation more info
involved_in regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell shape	IEA Inferred from Electronic Annotation more info
involved_in regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in response to activity	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to glucocorticoid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to iron ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to ischemia	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to muscle activity	IEA Inferred from Electronic Annotation more info
involved_in response to muscle activity	ISO Inferred from Sequence Orthology more info
involved_in response to ozone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in substrate adhesion-dependent cell spreading	IEA Inferred from Electronic Annotation more info
involved_in substrate adhesion-dependent cell spreading	ISO Inferred from Sequence Orthology more info
involved_in wound healing	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within wound healing	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basement membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basement membrane	IEA Inferred from Electronic Annotation more info
located_in basement membrane	ISO Inferred from Sequence Orthology more info
located_in collagen-containing extracellular matrix	IEA Inferred from Electronic Annotation more info
located_in collagen-containing extracellular matrix	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum-Golgi intermediate compartment	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum-Golgi intermediate compartment	ISO Inferred from Sequence Orthology more info
located_in extracellular exosome	IEA Inferred from Electronic Annotation more info
located_in extracellular exosome	ISO Inferred from Sequence Orthology more info
is_active_in extracellular matrix	ISO Inferred from Sequence Orthology more info
located_in extracellular matrix	ISO Inferred from Sequence Orthology more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
part_of fibrinogen complex	IEA Inferred from Electronic Annotation more info
part_of fibrinogen complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: fibronectin

Names: FN; fibronectin 2; fibronectin 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019143.2 → NP_062016.2 fibronectin precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000009

UniProtKB/Swiss-Prot

P04937, Q6LDX9

UniProtKB/TrEMBL

A0A096P6L8, A6KFG8

Related

ENSRNOP00000019772.4, ENSRNOT00000019772.8

Conserved Domains (6) summary

smart00059
Location:353 → 401

FN2; Fibronectin type 2 domain

smart00058
Location:187 → 231

FN1; Fibronectin type 1 domain

cd00061
Location:2384 → 2423

FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...

cd00063
Location:1994 → 2074

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00039
Location:232 → 271

fn1; Fibronectin type I domain

pfam00041
Location:1539 → 1620

fn3; Fibronectin type III domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086027.1 Reference GRCr8

Range

80645507..80714200 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006245156.5 → XP_006245218.1 fibronectin isoform X7

UniProtKB/TrEMBL

A0A8I5ZXR2, A6KFG4

Conserved Domains (6) summary

smart00059
Location:353 → 401

FN2; Fibronectin type 2 domain

smart00058
Location:187 → 231

FN1; Fibronectin type 1 domain

cd00061
Location:2203 → 2242

FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...

cd00063
Location:1813 → 1893

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00039
Location:232 → 271

fn1; Fibronectin type I domain

pfam00041
Location:1448 → 1529

fn3; Fibronectin type III domain
XM_006245159.5 → XP_006245221.1 fibronectin isoform X11

UniProtKB/TrEMBL

A6KFG7

Conserved Domains (6) summary

smart00059
Location:353 → 401

FN2; Fibronectin type 2 domain

smart00058
Location:187 → 231

FN1; Fibronectin type 1 domain

cd00061
Location:2083 → 2122

FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...

cd00063
Location:1813 → 1893

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00039
Location:232 → 271

fn1; Fibronectin type I domain

pfam00041
Location:1448 → 1529

fn3; Fibronectin type III domain
XM_006245157.5 → XP_006245219.1 fibronectin isoform X8

UniProtKB/TrEMBL

A0A8I5ZXR2

Conserved Domains (6) summary

smart00059
Location:353 → 401

FN2; Fibronectin type 2 domain

smart00058
Location:187 → 231

FN1; Fibronectin type 1 domain

cd00061
Location:2178 → 2217

FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...

cd00063
Location:1813 → 1893

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00039
Location:232 → 271

fn1; Fibronectin type I domain

pfam00041
Location:1448 → 1529

fn3; Fibronectin type III domain
XM_006245158.5 → XP_006245220.1 fibronectin isoform X10

UniProtKB/TrEMBL

A6KFG7

Conserved Domains (6) summary

smart00059
Location:353 → 401

FN2; Fibronectin type 2 domain

smart00058
Location:187 → 231

FN1; Fibronectin type 1 domain

cd00061
Location:2173 → 2212

FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...

cd00063
Location:1903 → 1983

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00039
Location:232 → 271

fn1; Fibronectin type I domain

pfam00041
Location:1448 → 1529

fn3; Fibronectin type III domain
XM_006245153.5 → XP_006245215.1 fibronectin isoform X5

UniProtKB/Swiss-Prot

P04937, Q6LDX9

Conserved Domains (6) summary

smart00059
Location:353 → 401

FN2; Fibronectin type 2 domain

smart00058
Location:187 → 231

FN1; Fibronectin type 1 domain

cd00061
Location:2268 → 2307

FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...

cd00063
Location:1903 → 1983

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00039
Location:232 → 271

fn1; Fibronectin type I domain

pfam00041
Location:1448 → 1529

fn3; Fibronectin type III domain
XM_006245152.5 → XP_006245214.1 fibronectin isoform X3

UniProtKB/Swiss-Prot

P04937, Q6LDX9

UniProtKB/TrEMBL

A0A8I6A5M1, A6KFG5

Related

ENSRNOP00000087332.1, ENSRNOT00000110905.2

Conserved Domains (6) summary

smart00059
Location:353 → 401

FN2; Fibronectin type 2 domain

smart00058
Location:187 → 231

FN1; Fibronectin type 1 domain

cd00061
Location:2293 → 2332

FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...

cd00063
Location:1903 → 1983

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00039
Location:232 → 271

fn1; Fibronectin type I domain

pfam00041
Location:1448 → 1529

fn3; Fibronectin type III domain
XM_017596301.3 → XP_017451790.1 fibronectin isoform X9

UniProtKB/TrEMBL

A6KFG7
XM_039083090.2 → XP_038939018.1 fibronectin isoform X4

UniProtKB/TrEMBL

A0A8I5ZXR2

Conserved Domains (6) summary

smart00059
Location:353 → 401

FN2; Fibronectin type 2 domain

smart00058
Location:187 → 231

FN1; Fibronectin type 1 domain

cd00061
Location:2269 → 2308

FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...

cd00063
Location:1904 → 1984

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00039
Location:232 → 271

fn1; Fibronectin type I domain

pfam00041
Location:1539 → 1620

fn3; Fibronectin type III domain
XM_006245151.5 → XP_006245213.1 fibronectin isoform X2

UniProtKB/TrEMBL

A0A8I5ZXR2, A6KFG6, F1LST1

Related

ENSRNOP00000054395.4, ENSRNOT00000057585.6

Conserved Domains (6) summary

smart00059
Location:353 → 401

FN2; Fibronectin type 2 domain

smart00058
Location:187 → 231

FN1; Fibronectin type 1 domain

cd00061
Location:2294 → 2333

FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...

cd00063
Location:1904 → 1984

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00039
Location:232 → 271

fn1; Fibronectin type I domain

pfam00041
Location:1539 → 1620

fn3; Fibronectin type III domain
XM_006245154.5 → XP_006245216.1 fibronectin isoform X6

UniProtKB/TrEMBL

A6KFG7

Conserved Domains (6) summary

smart00059
Location:353 → 401

FN2; Fibronectin type 2 domain

smart00058
Location:187 → 231

FN1; Fibronectin type 1 domain

cd00061
Location:2264 → 2303

FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...

cd00063
Location:1994 → 2074

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00039
Location:232 → 271

fn1; Fibronectin type I domain

pfam00041
Location:1539 → 1620

fn3; Fibronectin type III domain
XM_006245150.5 → XP_006245212.1 fibronectin isoform X1

UniProtKB/Swiss-Prot

P04937, Q6LDX9

Conserved Domains (6) summary

smart00059
Location:353 → 401

FN2; Fibronectin type 2 domain

smart00058
Location:187 → 231

FN1; Fibronectin type 1 domain

cd00061
Location:2359 → 2398

FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...

cd00063
Location:1994 → 2074

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00039
Location:232 → 271

fn1; Fibronectin type I domain

pfam00041
Location:1539 → 1620

fn3; Fibronectin type III domain