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    Esm1 endothelial cell-specific molecule 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 64536, updated on 9-Dec-2024

    Summary

    Official Symbol
    Esm1provided by RGD
    Official Full Name
    endothelial cell-specific molecule 1provided by RGD
    Primary source
    RGD:71013
    See related
    EnsemblRapid:ENSRNOG00000010797 AllianceGenome:RGD:71013
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Pg25
    Summary
    Predicted to enable hepatocyte growth factor receptor binding activity and integrin binding activity. Predicted to be involved in positive regulation of cell population proliferation; positive regulation of hepatocyte growth factor receptor signaling pathway; and sprouting angiogenesis. Predicted to be located in extracellular region. Orthologous to human ESM1 (endothelial cell specific molecule 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 114.0), Lung (RPKM 93.3) and 5 other tissues See more
    Orthologs
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    Genomic context

    See Esm1 in Genome Data Viewer
    Location:
    2q14
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (46609253..46617991)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (44876067..44884805)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (45104392..45113130)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene granzyme K Neighboring gene uncharacterized LOC134485841 Neighboring gene chondroitin sulfate proteoglycan 4B Neighboring gene uncharacterized LOC120100709

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables hepatocyte growth factor receptor binding  
    enables hepatocyte growth factor receptor binding  
    enables integrin binding  
    enables integrin binding  
    Component Evidence Code Pubs
    located_in extracellular region  

    General protein information

    Preferred Names
    endothelial cell-specific molecule 1
    Names
    ESM-1 secretory protein
    pineal specific PG25 protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022604.2NP_072126.1  endothelial cell-specific molecule 1 precursor

      See identical proteins and their annotated locations for NP_072126.1

      Status: PROVISIONAL

      Source sequence(s)
      BC070888
      UniProtKB/Swiss-Prot
      P97682
      UniProtKB/TrEMBL
      A6I5R2
      Related
      ENSRNOP00000014559.3, ENSRNOT00000014559.7
      Conserved Domains (1) summary
      pfam00219
      Location:2883
      IGFBP; Insulin-like growth factor binding protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      46609253..46617991
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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