Basp1 brain abundant, membrane attached signal protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Basp1provided by RGD
Full Name: brain abundant, membrane attached signal protein 1provided by RGD
Primary source: RGD:621491
See related: EnsemblRapid:ENSRNOG00000066065 AllianceGenome:RGD:621491
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: NAP22
Summary: Predicted to enable several functions, including calmodulin binding activity; transcription cis-regulatory region binding activity; and transcription corepressor activity. Predicted to be involved in several processes, including podocyte differentiation; protein homooligomerization; and substantia nigra development. Located in cytoplasm. Orthologous to human BASP1 (brain abundant membrane attached signal protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 495.4), Kidney (RPKM 91.0) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q22

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (77546628..77594297, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (75816130..75863801, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (77586424..77632626, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study suggests the participation of NAP-22 in the membrane cycling through binding to dynamin and acidic membrane lipids at the presynaptic region.
Title: Interaction of dynamin I with NAP-22, a neuronal protein enriched in the presynaptic region.
We conclude that BASP1 oligomer is a non-pathological physiologically relevant functional form of this protein.
Title: [Amyloid-like oligomers of presynaptic protein BASP1].
In rat brain, the amounts of all BASP1 forms per cell systematically increase during development and remain at the highest levels in adult animals.
Title: BASP1 and its N-end fragments (BNEMFs) dynamics in rat brain during development.
NAP-22 could participate in the transport of GAD65 and GAD67 to the presynaptic termini and their retention on the synaptic vesicles as an anchoring protein.
Title: Interaction of NAP-22 with brain glutamic acid decarboxylase (GAD).
In spermatozoa, as in chromatoid body, BASP1 and MARCKS may bind Ca(2+)-calmodulin and therefore contribute to the activation of calcium-dependent biochemical processes.
Title: Immunoelectron microscopic study of BASP1 and MARCKS location in the early and late rat spermatids.
Hence, the CapZ-NAP-22 complex could work as the nucleation site of actin polymerization or as the actin filament-anchoring site on the membrane microdomain.
Title: Biochemical interaction of an actin-capping protein, CapZ, with NAP-22.
Since the application of maitotoxin, a calcium ion channel, caused the diminution of NAP-22 and cholesterol positive spots, the distribution of these molecules are considered under the calcium regulation
Title: Morphological analysis on the distribution of membrane lipids and a membrane protein, NAP-22, during neuronal development in vitro.
regulates functions in the motor, sensory and autonomic nerve terminals in the peripheral nervous system
Title: Motor, sensory and autonomic nerve terminals containing NAP-22 immunoreactivity in the rat muscle.
Molecular characterization of brain-derived membrane microdomain shows localization of Basp1 (NAP-22) suggesting participation of the raft in the regulation of ion transport in addition to the presence of heterogeneity of raft domains in neurons.
Title: Localization of the Cl(-)-ATPase activity on NAP-22 enriched membrane microdomain (raft) of rat brain.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D2Rat203 (e-PCR), detects polymorphism
- UniSTS:227362

RH134721 (e-PCR)
- UniSTS:217999

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables calmodulin binding	ISO Inferred from Sequence Orthology more info
enables protein domain specific binding	IEA Inferred from Electronic Annotation more info
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables transcription cis-regulatory region binding	IBA Inferred from Biological aspect of Ancestor more info
enables transcription cis-regulatory region binding	IEA Inferred from Electronic Annotation more info
enables transcription cis-regulatory region binding	ISO Inferred from Sequence Orthology more info
enables transcription cis-regulatory region binding	ISS Inferred from Sequence or Structural Similarity more info
enables transcription corepressor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription corepressor activity	IEA Inferred from Electronic Annotation more info
enables transcription corepressor activity	ISO Inferred from Sequence Orthology more info
enables transcription corepressor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in negative regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in podocyte differentiation	IEA Inferred from Electronic Annotation more info
involved_in podocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in protein homooligomerization	IEA Inferred from Electronic Annotation more info
involved_in protein homooligomerization	ISO Inferred from Sequence Orthology more info
involved_in substantia nigra development	ISO Inferred from Sequence Orthology more info	PubMed
involved_in supramolecular fiber organization	IEA Inferred from Electronic Annotation more info
involved_in supramolecular fiber organization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of COP9 signalosome	IEA Inferred from Electronic Annotation more info
part_of COP9 signalosome	ISO Inferred from Sequence Orthology more info
located_in PML body	IEA Inferred from Electronic Annotation more info
located_in PML body	ISO Inferred from Sequence Orthology more info
located_in cell junction	IEA Inferred from Electronic Annotation more info
located_in cell junction	ISO Inferred from Sequence Orthology more info
located_in chromatin	IEA Inferred from Electronic Annotation more info
located_in chromatin	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in growth cone	IEA Inferred from Electronic Annotation more info
located_in nuclear matrix	IEA Inferred from Electronic Annotation more info
located_in nuclear matrix	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	IEA Inferred from Electronic Annotation more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: brain acid soluble protein 1

Names: 22 kDa neuronal tissue-enriched acidic protein; brain acidic membrane protein; neuronal axonal membrane protein NAP-22

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022300.2 → NP_071636.2 brain acid soluble protein 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002

UniProtKB/TrEMBL

A0A8I6A304

Related

ENSRNOP00000112205.1, ENSRNOT00000152147.1

Conserved Domains (1) summary

pfam05466
Location:12 → 221

BASP1; Brain acid soluble protein 1 (BASP1 protein)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

77546628..77594297 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039103039.1 → XP_038958967.1 brain acid soluble protein 1 isoform X1

UniProtKB/TrEMBL

A0A8I6A304

Related

ENSRNOP00000106594.1, ENSRNOT00000136508.1

Conserved Domains (1) summary

pfam05466
Location:12 → 221

BASP1; Brain acid soluble protein 1 (BASP1 protein)