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    Kgd4 alpha-ketoglutarate dehydrogenase subunit 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 294696, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Kgd4provided by RGD
    Official Full Name
    alpha-ketoglutarate dehydrogenase subunit 4provided by RGD
    Primary source
    RGD:1309315
    See related
    EnsemblRapid:ENSRNOG00000061213 AllianceGenome:RGD:1309315
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Mrps36
    Summary
    Predicted to enable protein-macromolecule adaptor activity. Predicted to be involved in 2-oxoglutarate metabolic process and tricarboxylic acid cycle. Predicted to be located in mitochondrion. Predicted to be part of oxoglutarate dehydrogenase complex. Orthologous to human KGD4 (alpha-ketoglutarate dehydrogenase subunit 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 759.4), Muscle (RPKM 498.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Kgd4 in Genome Data Viewer
    Location:
    2q12
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (33604611..33614988, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (31870549..31878335, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (30740620..30750916, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 125 Neighboring gene cyclin-dependent kinase 7 Neighboring gene KtI12 chromatin associated, pseudogene 1 Neighboring gene uncharacterized LOC134485587 Neighboring gene centromere protein H

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The small subunit of the mammalian mitochondrial ribosome. Identification of the full complement of ribosomal proteins present. Cavdar Koc E, et al. J Biol Chem, 2001 Jun 1. PMID 11279123
    2. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853
    3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein-macromolecule adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in 2-oxoglutarate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in 2-oxoglutarate metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tricarboxylic acid cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of oxoglutarate dehydrogenase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of oxoglutarate dehydrogenase complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    alpha-ketoglutarate dehydrogenase component 4
    Names
    28S ribosomal protein S36, mitochondrial
    mitochondrial ribosomal protein S36

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191605.3 → NP_001178534.1  alpha-ketoglutarate dehydrogenase component 4

      See identical proteins and their annotated locations for NP_001178534.1

      Status: VALIDATED

      Source sequence(s)
      AI070491, FM072467, FQ224224
      UniProtKB/TrEMBL
      A6I5A6, M0R776
      Conserved Domains (1) summary
      pfam10937
      Location:80 → 101
      DUF2638; Protein of unknown function (DUF2638)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      33604611..33614988 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063281501.1 → XP_063137571.1  alpha-ketoglutarate dehydrogenase component 4 isoform X1

      Related
      ENSRNOP00000090399.2, ENSRNOT00000095661.2

    2. XM_063281502.1 → XP_063137572.1  alpha-ketoglutarate dehydrogenase component 4 isoform X2

      UniProtKB/TrEMBL
      M0R776
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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