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    Klhl25 kelch-like family member 25 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 293023, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Klhl25provided by RGD
    Official Full Name
    kelch-like family member 25provided by RGD
    Primary source
    RGD:1310815
    See related
    EnsemblRapid:ENSRNOG00000010959 AllianceGenome:RGD:1310815
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1310815
    Summary
    Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in several processes, including positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation; regulation of fatty acid metabolic process; and ubiquitin-dependent protein catabolic process. Predicted to be located in cytoplasm. Predicted to be part of Cul3-RING ubiquitin ligase complex. Orthologous to human KLHL25 (kelch like family member 25). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 65.3), Kidney (RPKM 54.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Klhl25 in Genome Data Viewer
    Location:
    1q31
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (139134655..139159898)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (129724894..129750142)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (137333880..137359107, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134485140 Neighboring gene biogenesis of ribosomes BRX1, pseudogene 1 Neighboring gene 60S ribosomal protein L7a pseudogene Neighboring gene Glyceraldehyde-3-phosphate dehydrogenase, pseudogene 69

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Translational homeostasis via the mRNA cap-binding protein, eIF4E. Yanagiya A, et al. Mol Cell, 2012 Jun 29. PMID 22578813, Free PMC Article
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC116251

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ubiquitin-like ligase-substrate adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-like ligase-substrate adaptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of fatty acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of fatty acid oxidation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of fatty acid oxidation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of translational initiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of translational initiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of Cul3-RING ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of Cul3-RING ubiquitin ligase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    kelch-like protein 25
    Names
    ENC-2
    ectoderm-neural cortex protein 2
    kelch-like 25

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039006.1 → NP_001034095.1  kelch-like protein 25

      See identical proteins and their annotated locations for NP_001034095.1

      Status: PROVISIONAL

      Source sequence(s)
      BC099111
      UniProtKB/Swiss-Prot
      Q4KLM4
      UniProtKB/TrEMBL
      A6JC16
      Related
      ENSRNOP00000089869.1, ENSRNOT00000097328.2
      Conserved Domains (3) summary
      PHA03098
      Location:39 → 566
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:330 → 374
      Kelch; KELCH repeat [structural motif]
      cd18254
      Location:24 → 151
      BTB_POZ_KLHL25; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 25 (KLHL25)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      139134655..139159898
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008759505.4 → XP_008757727.1  kelch-like protein 25 isoform X1

      See identical proteins and their annotated locations for XP_008757727.1

      UniProtKB/Swiss-Prot
      Q4KLM4
      UniProtKB/TrEMBL
      A6JC16
      Related
      ENSRNOP00000102094.1, ENSRNOT00000123188.1
      Conserved Domains (3) summary
      PHA03098
      Location:39 → 566
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:330 → 374
      Kelch; KELCH repeat [structural motif]
      cd18254
      Location:24 → 151
      BTB_POZ_KLHL25; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 25 (KLHL25)

    2. XM_063284515.1 → XP_063140585.1  kelch-like protein 25 isoform X1

      UniProtKB/Swiss-Prot
      Q4KLM4
      UniProtKB/TrEMBL
      A6JC16

    3. XM_006229380.4 → XP_006229442.1  kelch-like protein 25 isoform X1

      See identical proteins and their annotated locations for XP_006229442.1

      UniProtKB/Swiss-Prot
      Q4KLM4
      UniProtKB/TrEMBL
      A6JC16
      Conserved Domains (3) summary
      PHA03098
      Location:39 → 566
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:330 → 374
      Kelch; KELCH repeat [structural motif]
      cd18254
      Location:24 → 151
      BTB_POZ_KLHL25; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 25 (KLHL25)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4KLM4.1 GenPept UniProtKB/Swiss-Prot:Q4KLM4

    Gene LinkOut

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